Nomascus leucogenys      Gemini of cajal body


※ Gemini of cajal body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Gemini of Cajal bodies, also called as Gemini of coiled bodies or nuclear gems, is a kind of these bodies located in Nucleus of spherical shape, It do not contain snRNPs. The function of nuclear gems is still unknown, may be related to further maturation, storage or recycling of splicing factors (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 12 genes.  Reviewed (0 or Unreviewed (12

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Nol-1786
ENSNLEG00000004040.3
A0A2I3H3H8
DDX20
2
LLPS-Nol-3027
ENSNLEG00000016218.3
G1S2J4
FUS
3
LLPS-Nol-0335
ENSNLEG00000004013.3
G1QVC8
GEMIN2
4
LLPS-Nol-0156
ENSNLEG00000000531.2
G1QI69
GEMIN4
5
LLPS-Nol-3130
ENSNLEG00000016630.3
G1S408
GEMIN5
6
LLPS-Nol-1043
ENSNLEG00000033616.1
A0A2I3HW59
GEMIN6
7
LLPS-Nol-0715
ENSNLEG00000001846.3
G1QMR1
GEMIN7
8
LLPS-Nol-1845
ENSNLEG00000034467.1
A0A2I3G8U1
GEMIN8
9
LLPS-Nol-2890
ENSNLEG00000004454.2
A0A2I3G9J7
LOC100585728
10
LLPS-Nol-2553
ENSNLEG00000004899.3
G1QYH7
SNRNP70
11
LLPS-Nol-4102
ENSNLEG00000004160.3
A0A2I3HAE3
STRAP
12
LLPS-Nol-1964
ENSNLEG00000009512.3
A0A2I3G8J5
TARDBP