Myotis lucifugus      Gemini of cajal body


※ Gemini of cajal body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Gemini of Cajal bodies, also called as Gemini of coiled bodies or nuclear gems, is a kind of these bodies located in Nucleus of spherical shape, It do not contain snRNPs. The function of nuclear gems is still unknown, may be related to further maturation, storage or recycling of splicing factors (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 12 genes.  Reviewed (0 or Unreviewed (12

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Myl-0575
ENSMLUG00000004806.2
G1P397
2
LLPS-Myl-1242
ENSMLUG00000009676.2
G1PE87
DDX20
3
LLPS-Myl-1317
ENSMLUG00000002619.2
G1NYA1
GEMIN2
4
LLPS-Myl-1041
ENSMLUG00000001494.2
G1Q9V9
GEMIN4
5
LLPS-Myl-0767
ENSMLUG00000016836.2
G1PVI8
GEMIN5
6
LLPS-Myl-2444
ENSMLUG00000014772.2
G1PQR4
GEMIN6
7
LLPS-Myl-0526
ENSMLUG00000002175.2
G1NX93
GEMIN7
8
LLPS-Myl-0669
ENSMLUG00000010141.2
G1PFA8
GEMIN8
9
LLPS-Myl-3312
ENSMLUG00000010603.2
G1PGA9
SMN1
10
LLPS-Myl-0363
ENSMLUG00000011766.2
G1PJ07
SNRNP70
11
LLPS-Myl-0621
ENSMLUG00000002797.1
G1NYP5
STRAP
12
LLPS-Myl-2479
ENSMLUG00000004263.2
G1P208
TARDBP