Mustela putorius furo      Gemini of cajal body


※ Gemini of cajal body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Gemini of Cajal bodies, also called as Gemini of coiled bodies or nuclear gems, is a kind of these bodies located in Nucleus of spherical shape, It do not contain snRNPs. The function of nuclear gems is still unknown, may be related to further maturation, storage or recycling of splicing factors (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 11 genes.  Reviewed (0 or Unreviewed (11

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Mup-0461
ENSMPUG00000004035.1
M3XY50
2
LLPS-Mup-3631
ENSMPUG00000014470.1
M3YSQ0
3
LLPS-Mup-0278
ENSMPUG00000004921.1
M3Y0N0
DDX20
4
LLPS-Mup-0104
ENSMPUG00000016240.1
M3YXS6
GEMIN2
5
LLPS-Mup-0231
ENSMPUG00000013757.1
M3YQP5
GEMIN4
6
LLPS-Mup-2455
ENSMPUG00000013538.1
M3YQ27
GEMIN5
7
LLPS-Mup-2977
ENSMPUG00000010434.1
M3YGA1
GEMIN6
8
LLPS-Mup-2890
ENSMPUG00000019379.1
M3Z6N9
GEMIN7
9
LLPS-Mup-2058
ENSMPUG00000002595.1
M3XU16
GEMIN8
10
LLPS-Mup-2964
ENSMPUG00000003258.1
M3XVX6
SNRNP70
11
LLPS-Mup-3174
ENSMPUG00000011519.1
M3YJC1
STRAP