Mus musculus      Gemini of cajal body


※ Gemini of cajal body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Gemini of Cajal bodies, also called as Gemini of coiled bodies or nuclear gems, is a kind of these bodies located in Nucleus of spherical shape, It do not contain snRNPs. The function of nuclear gems is still unknown, may be related to further maturation, storage or recycling of splicing factors (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 12 genes.  Reviewed (4 or Unreviewed (8

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Mum-0246
ENSMUSG00000030795.18
P56959
Fus
2
LLPS-Mum-0797
ENSMUSG00000021645.16
P97801
Smn1
3
LLPS-Mum-0414
ENSMUSG00000063511.11
Q62376
Snrnp70
4
LLPS-Mum-1443
ENSMUSG00000041459.15
Q921F2
Tardbp
5
LLPS-Mum-0927
ENSMUSG00000027905.15
Q9JJY4
Ddx20
6
LLPS-Mum-1550
ENSMUSG00000060121.15
Q9CQQ4
Gemin2
7
LLPS-Mum-0051
ENSMUSG00000049396.6
Q6P6L6
Gemin4
8
LLPS-Mum-2139
ENSMUSG00000037275.14
Q8BX17
Gemin5
9
LLPS-Mum-1985
ENSMUSG00000055760.12
Q9CX53
Gemin6
10
LLPS-Mum-2144
ENSMUSG00000044709.6
Q9CWY4
Gemin7
11
LLPS-Mum-3645
ENSMUSG00000040621.14
Q8BHE1
Gemin8
12
LLPS-Mum-0433
ENSMUSG00000030224.10
Q9Z1Z2
Strap