Homo sapiens      Gemini of cajal body


※ Gemini of cajal body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Gemini of Cajal bodies, also called as Gemini of coiled bodies or nuclear gems, is a kind of these bodies located in Nucleus of spherical shape, It do not contain snRNPs. The function of nuclear gems is still unknown, may be related to further maturation, storage or recycling of splicing factors (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 12 genes.  Reviewed (12 or Unreviewed (0

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Hos-0376
ENSG00000064703.11
Q9UHI6
DDX20
2
LLPS-Hos-1390
ENSG00000089280.18
P35637
FUS
3
LLPS-Hos-2600
ENSG00000092208.17
O14893
GEMIN2
4
LLPS-Hos-2195
ENSG00000179409.10
P57678
GEMIN4
5
LLPS-Hos-2004
ENSG00000082516.8
Q8TEQ6
GEMIN5
6
LLPS-Hos-2584
ENSG00000152147.10
Q8WXD5
GEMIN6
7
LLPS-Hos-0881
ENSG00000142252.10
Q9H840
GEMIN7
8
LLPS-Hos-0980
ENSG00000046647.13
Q9NWZ8
GEMIN8
9
LLPS-Hos-0485
ENSG00000172062.16
Q16637
SMN2
10
LLPS-Hos-1361
ENSG00000104852.14
P08621
SNRNP70
11
LLPS-Hos-0833
ENSG00000023734.10
Q9Y3F4
STRAP
12
LLPS-Hos-2689
ENSG00000120948.17
Q13148
TARDBP