Gallus gallus      Gemini of cajal body


※ Gemini of cajal body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Gemini of Cajal bodies, also called as Gemini of coiled bodies or nuclear gems, is a kind of these bodies located in Nucleus of spherical shape, It do not contain snRNPs. The function of nuclear gems is still unknown, may be related to further maturation, storage or recycling of splicing factors (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 10 genes.  Reviewed (0 or Unreviewed (10

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Gaga-0228
ENSGALG00000004817.7
F1NFZ8
2
LLPS-Gaga-0954
ENSGALG00000010154.7
3
LLPS-Gaga-3205
ENSGALG00000032219.2
A0A1D5PPI6
4
LLPS-Gaga-1402
ENSGALG00000001504.7
F1P5C0
DDX20
5
LLPS-Gaga-2076
ENSGALG00000003937.6
F1NYJ6
GEMIN5
6
LLPS-Gaga-2965
ENSGALG00000013821.5
E1BRN1
GEMIN6
7
LLPS-Gaga-2620
ENSGALG00000016574.7
E1BTB3
GEMIN8
8
LLPS-Gaga-0804
ENSGALG00000002430.7
Q98SU9
SMN
9
LLPS-Gaga-1354
ENSGALG00000013092.6
Q5ZL33
STRAP
10
LLPS-Gaga-0849
ENSGALG00000002906.7
F1NBY1
TARDBP