Felis catus      Gemini of cajal body


※ Gemini of cajal body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Gemini of Cajal bodies, also called as Gemini of coiled bodies or nuclear gems, is a kind of these bodies located in Nucleus of spherical shape, It do not contain snRNPs. The function of nuclear gems is still unknown, may be related to further maturation, storage or recycling of splicing factors (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 12 genes.  Reviewed (0 or Unreviewed (12

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Fec-0580
ENSFCAG00000025736.3
M3XAQ7
DDX20
2
LLPS-Fec-0327
ENSFCAG00000027928.3
M3X5Q2
FUS
3
LLPS-Fec-3528
ENSFCAG00000029921.3
M3WTJ3
GEMIN2
4
LLPS-Fec-3220
ENSFCAG00000024115.3
M3X679
GEMIN4
5
LLPS-Fec-2512
ENSFCAG00000000595.5
M3VV26
GEMIN5
6
LLPS-Fec-4071
ENSFCAG00000008101.3
M3W8Z2
GEMIN6
7
LLPS-Fec-2623
ENSFCAG00000043198.1
A0A337SIN5
GEMIN7
8
LLPS-Fec-2449
ENSFCAG00000014428.5
M3WKP7
GEMIN8
9
LLPS-Fec-0229
ENSFCAG00000028292.3
Q8HYB8
SMN1
10
LLPS-Fec-2248
ENSFCAG00000042603.1
A0A337S6L0
SNRNP70
11
LLPS-Fec-1853
ENSFCAG00000024292.3
A0A337SU47
STRAP
12
LLPS-Fec-0068
ENSFCAG00000000050.4
A0A2I2U8C8
TARDBP