Dipodomys ordii      Gemini of cajal body


※ Gemini of cajal body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Gemini of Cajal bodies, also called as Gemini of coiled bodies or nuclear gems, is a kind of these bodies located in Nucleus of spherical shape, It do not contain snRNPs. The function of nuclear gems is still unknown, may be related to further maturation, storage or recycling of splicing factors (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 12 genes.  Reviewed (0 or Unreviewed (12

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Dio-3512
ENSDORG00000011660.2
A0A1S3FWK4
Ddx20
2
LLPS-Dio-0100
ENSDORG00000014218.2
A0A1S3ERL6
Fus
3
LLPS-Dio-2318
ENSDORG00000003814.2
A0A1S3ETS6
Gemin2
4
LLPS-Dio-2489
ENSDORG00000007547.2
A0A1S3F619
Gemin4
5
LLPS-Dio-2857
ENSDORG00000029961.1
A0A1S3GQV6
Gemin5
6
LLPS-Dio-2464
ENSDORG00000023512.1
A0A1S3FBG1
Gemin6
7
LLPS-Dio-3163
ENSDORG00000027339.1
A0A1S3GJJ0
Gemin7
8
LLPS-Dio-3125
ENSDORG00000013897.2
A0A1S3GVW4
Gemin8
9
LLPS-Dio-2420
ENSDORG00000007082.2
A0A1S3F5M2
LOC105985379
10
LLPS-Dio-1557
ENSDORG00000010228.2
A0A1S3G3B8
Snrnp70
11
LLPS-Dio-1595
ENSDORG00000023312.1
A0A1S3FXD6
Strap
12
LLPS-Dio-1382
ENSDORG00000007465.2
A0A1S3GNS0
Tardbp