Danio rerio      Gemini of cajal body


※ Gemini of cajal body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Gemini of Cajal bodies, also called as Gemini of coiled bodies or nuclear gems, is a kind of these bodies located in Nucleus of spherical shape, It do not contain snRNPs. The function of nuclear gems is still unknown, may be related to further maturation, storage or recycling of splicing factors (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 9 genes.  Reviewed (0 or Unreviewed (9

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Dar-0444
ENSDARG00000004452.10
2
LLPS-Dar-0359
ENSDARG00000061204.9
P0C218
ddx20
3
LLPS-Dar-0213
ENSDARG00000015638.10
A0A2R8Q828
gemin2
4
LLPS-Dar-3031
ENSDARG00000115829.1
A0A2R8QNY3
gemin4
5
LLPS-Dar-1907
ENSDARG00000079257.5
E9QH84
gemin5
6
LLPS-Dar-1766
ENSDARG00000041011.5
F1R879
gemin7
7
LLPS-Dar-3326
ENSDARG00000115240.1
F1QAZ5
gemin8
8
LLPS-Dar-1484
ENSDARG00000018494.7
Q9W6S8
smn1
9
LLPS-Dar-0786
ENSDARG00000007405.8
Q7ZW92
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