Cercocebus atys      Gemini of cajal body


※ Gemini of cajal body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Gemini of Cajal bodies, also called as Gemini of coiled bodies or nuclear gems, is a kind of these bodies located in Nucleus of spherical shape, It do not contain snRNPs. The function of nuclear gems is still unknown, may be related to further maturation, storage or recycling of splicing factors (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 12 genes.  Reviewed (0 or Unreviewed (12

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Cea-4124
ENSCATG00000037002.1
A0A2K5MQ51
2
LLPS-Cea-2699
ENSCATG00000039030.1
A0A2K5N3E2
DDX20
3
LLPS-Cea-2513
ENSCATG00000034413.1
A0A2K5M862
FUS
4
LLPS-Cea-1448
ENSCATG00000042473.1
A0A2K5NQC6
GEMIN2
5
LLPS-Cea-1456
ENSCATG00000022135.1
A0A2K5L3B0
GEMIN4
6
LLPS-Cea-2153
ENSCATG00000038574.1
A0A2K5N079
GEMIN5
7
LLPS-Cea-2529
ENSCATG00000030487.1
A0A2K5LI66
GEMIN6
8
LLPS-Cea-0248
ENSCATG00000015354.1
A0A2K5KUD9
GEMIN7
9
LLPS-Cea-2770
ENSCATG00000042167.1
A0A2K5NNW2
GEMIN8
10
LLPS-Cea-1649
ENSCATG00000016149.1
A0A2K5KVP3
SNRNP70
11
LLPS-Cea-2835
ENSCATG00000016528.1
A0A2K5KW36
STRAP
12
LLPS-Cea-0980
ENSCATG00000031367.1
A0A2K5LQ78
TARDBP