Canis familiaris      Gemini of cajal body


※ Gemini of cajal body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Gemini of Cajal bodies, also called as Gemini of coiled bodies or nuclear gems, is a kind of these bodies located in Nucleus of spherical shape, It do not contain snRNPs. The function of nuclear gems is still unknown, may be related to further maturation, storage or recycling of splicing factors (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 12 genes.  Reviewed (0 or Unreviewed (12

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Caf-3408
ENSCAFG00000013674.4
F1PXG6
DDX20
2
LLPS-Caf-0611
ENSCAFG00000016862.4
F1PBJ4
FUS
3
LLPS-Caf-1170
ENSCAFG00000013859.4
F1PQ87
GEMIN2
4
LLPS-Caf-0947
ENSCAFG00000024432.2
F1PFG3
GEMIN4
5
LLPS-Caf-2438
ENSCAFG00000017614.4
E2RIE8
GEMIN5
6
LLPS-Caf-0340
ENSCAFG00000029480.1
J9P8K8
GEMIN6
7
LLPS-Caf-0800
ENSCAFG00000004570.1
E2RHG3
GEMIN7
8
LLPS-Caf-2937
ENSCAFG00000028737.1
J9P1M4
GEMIN8
9
LLPS-Caf-0389
ENSCAFG00000007812.3
K9J6P1
SMN
10
LLPS-Caf-0159
ENSCAFG00000003711.4
F6V5G7
SNRNP70
11
LLPS-Caf-2106
ENSCAFG00000012679.3
E2RBU1
STRAP
12
LLPS-Caf-0428
ENSCAFG00000016759.3
E2QS43
TARDBP