Anolis carolinensis      Gemini of cajal body


※ Gemini of cajal body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Gemini of Cajal bodies, also called as Gemini of coiled bodies or nuclear gems, is a kind of these bodies located in Nucleus of spherical shape, It do not contain snRNPs. The function of nuclear gems is still unknown, may be related to further maturation, storage or recycling of splicing factors (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 11 genes.  Reviewed (0 or Unreviewed (11

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Anc-0007
ENSACAG00000006235.3
G1KF87
DDX20
2
LLPS-Anc-0018
ENSACAG00000006776.3
H9GC18
FUS
3
LLPS-Anc-0589
ENSACAG00000015872.2
G1KRR9
GEMIN2
4
LLPS-Anc-3348
ENSACAG00000016003.2
H9GMU7
GEMIN4
5
LLPS-Anc-3126
ENSACAG00000003900.3
H9G8C2
GEMIN5
6
LLPS-Anc-0942
ENSACAG00000006134.1
G1KF12
GEMIN6
7
LLPS-Anc-1054
ENSACAG00000004282.2
H9G8Q1
GEMIN7
8
LLPS-Anc-3238
ENSACAG00000001988.3
G1KA17
GEMIN8
9
LLPS-Anc-3538
ENSACAG00000010017.3
G1KJN6
LOC100553231
10
LLPS-Anc-3219
ENSACAG00000013276.3
G1KNI8
SNRNP70
11
LLPS-Anc-3930
ENSACAG00000014378.3
H9GL15
STRAP