Macaca mulatta      Droplet


※ Droplet introduction

    Interactions between diverse synthetic, multivalent macromolecules (including multi-domain proteins and RNA) produce sharp liquid-liquid-demixing phase separations, generating micrometre-sized liquid droplets in aqueous solution (1-2). In vitro phase separation assays with purified proteins have become the standard way to investigate proteins that form membrane-less compartments. By now, various proteins have been purified and tested for their ability to phase separate and form liquid condensates in vitro (3).

References
1. Li P., Banjade S., Cheng H.C., et al. (2012) Phase transitions in the assembly of multivalent signalling proteins. Nature, 483, 336-40. PMID: 22398450
2. Kato M., Han T.W., Xie S., et al. (2012) Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels. Cell, 149, 753-67. PMID: 22579281
3. Alberti S., Saha S., Woodruff J.B., et al. (2018) A User’s Guide for Phase Separation Assays with Purified Proteins. J. Mol. Biol., 430, 4806-4820. PMID: 29944854


There are 106 genes.  Reviewed (0 or Unreviewed (106

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Mam-0180
ENSMMUG00000042906.1
A0A1D5R1A9
2
LLPS-Mam-0512
ENSMMUG00000005139.3
F7DC82
3
LLPS-Mam-0747
ENSMMUG00000023352.3
F7HKB2
4
LLPS-Mam-0989
ENSMMUG00000037648.1
A0A1D5QBC4
5
LLPS-Mam-1177
ENSMMUG00000048152.1
F7BJS7
6
LLPS-Mam-1377
ENSMMUG00000031876.2
F7GX65
7
LLPS-Mam-3578
ENSMMUG00000007928.3
F7HT04
8
LLPS-Mam-0317
ENSMMUG00000008045.3
A0A1D5QH79
AGO2
9
LLPS-Mam-0615
ENSMMUG00000006284.3
A0A1D5QK39
AK2
10
LLPS-Mam-0552
ENSMMUG00000014384.3
G7MNB1
APP
11
LLPS-Mam-2380
ENSMMUG00000003298.3
F7FFI7
ATXN2L
12
LLPS-Mam-1921
ENSMMUG00000000070.3
F7GNU0
AURKA
13
LLPS-Mam-2132
ENSMMUG00000002997.3
F6VVA5
AURKB
14
LLPS-Mam-1459
ENSMMUG00000016508.3
F7G0U4
C15H9orf72
15
LLPS-Mam-4362
ENSMMUG00000021393.3
F7FD93
CAMK2G
16
LLPS-Mam-4387
ENSMMUG00000019882.3
F7GRX5
CBX1
17
LLPS-Mam-1346
ENSMMUG00000046417.1
I0FVS0
CBX2
18
LLPS-Mam-1267
ENSMMUG00000004950.3
F7C841
CBX5
19
LLPS-Mam-1604
ENSMMUG00000018621.3
F6XZK0
CDK7
20
LLPS-Mam-3392
ENSMMUG00000022101.3
F7DU86
CIRBP
21
LLPS-Mam-2174
ENSMMUG00000013008.3
A0A1D5QYY1
CSTF2
22
LLPS-Mam-1251
ENSMMUG00000013267.3
F6ZBN2
CTTN
23
LLPS-Mam-2512
ENSMMUG00000004639.3
A0A1D5Q7W8
DAB2IP
24
LLPS-Mam-0869
ENSMMUG00000004287.3
I0FPK1
DAXX
25
LLPS-Mam-2882
ENSMMUG00000003047.3
A0A1D5RAA0
DAZAP1
26
LLPS-Mam-0315
ENSMMUG00000010992.3
F7GS64
DCP1B
27
LLPS-Mam-0962
ENSMMUG00000013553.3
F7FRQ8
DCP2
28
LLPS-Mam-1049
ENSMMUG00000017569.3
A0A1D5Q9J1
DDX3X
29
LLPS-Mam-1012
ENSMMUG00000017386.3
A0A1D5R0N7
DDX4
30
LLPS-Mam-0304
ENSMMUG00000018651.3
H9FQP5
DDX6
31
LLPS-Mam-0652
ENSMMUG00000010536.3
F7D120
DLG4
32
LLPS-Mam-1958
ENSMMUG00000018131.3
F7FBT7
DYRK1A
33
LLPS-Mam-0173
ENSMMUG00000011071.3
F7GKJ5
EDC3
34
LLPS-Mam-0541
ENSMMUG00000004149.3
A0A1D5QF97
EIF4G3
35
LLPS-Mam-4575
ENSMMUG00000044533.1
A0A1D5R663
ELN
36
LLPS-Mam-4217
ENSMMUG00000021112.3
G7MZS5
ESRP1
37
LLPS-Mam-2464
ENSMMUG00000021374.3
F7FI06
EWSR1
38
LLPS-Mam-0271
ENSMMUG00000022725.3
A0A1D5RDW4
FBL
39
LLPS-Mam-0259
ENSMMUG00000013668.3
F7GCM2
FLNA
40
LLPS-Mam-3678
ENSMMUG00000000706.3
F6YS73
FLNB
41
LLPS-Mam-3109
ENSMMUG00000015814.3
I0FIR3
FMR1
42
LLPS-Mam-3324
ENSMMUG00000019637.3
F6T5U5
FUS
43
LLPS-Mam-2880
ENSMMUG00000017017.3
F6PKK7
FYN
44
LLPS-Mam-0794
ENSMMUG00000021225.3
F7HTU1
GAR1
45
LLPS-Mam-0393
ENSMMUG00000008419.3
F6VCJ0
GNL2
46
LLPS-Mam-2993
ENSMMUG00000004756.3
G7NGP6
GRB2
47
LLPS-Mam-3144
ENSMMUG00000023178.3
A0A1D5QHP9
GSPT1
48
LLPS-Mam-1428
ENSMMUG00000003619.3
I2CYL4
HNRNPA2B1
49
LLPS-Mam-3469
ENSMMUG00000001858.3
A0A1D5QW22
HNRNPA3
50
LLPS-Mam-3695
ENSMMUG00000015777.3
F6QIA8
HNRNPDL
51
LLPS-Mam-2725
ENSMMUG00000010843.3
F7G3L4
HNRNPH1
52
LLPS-Mam-1516
ENSMMUG00000009792.3
F6Y030
HNRNPH3
53
LLPS-Mam-0610
ENSMMUG00000023294.3
F7FF24
HOMER3
54
LLPS-Mam-2899
ENSMMUG00000013531.3
F6Z6Q9
IPO5
55
LLPS-Mam-1439
ENSMMUG00000007626.3
A0A1D5Q3A8
ITSN1
56
LLPS-Mam-0124
ENSMMUG00000018256.3
F7DZP0
KPNA2
57
LLPS-Mam-0544
ENSMMUG00000019760.3
F7AQQ3
KPNB1
58
LLPS-Mam-2695
ENSMMUG00000043332.1
F7EUV8
LAT
59
LLPS-Mam-1002
ENSMMUG00000003472.3
F7EBC6
LBR
60
LLPS-Mam-0642
ENSMMUG00000003565.3
F7ETJ8
LGALS3
61
LLPS-Mam-1305
ENSMMUG00000022339.3
F6ZIP0
LOC106998368
62
LLPS-Mam-1916
ENSMMUG00000023553.2
F7HI62
LOC697790
63
LLPS-Mam-2741
ENSMMUG00000019580.2
F7BG13
LOC703365
64
LLPS-Mam-3244
ENSMMUG00000012989.3
F7HT55
LOC711588
65
LLPS-Mam-1531
ENSMMUG00000004405.3
H9ENV5
LSM4
66
LLPS-Mam-1901
ENSMMUG00000008987.3
P30201
LYZ
67
LLPS-Mam-3053
ENSMMUG00000045825.1
A0A1D5QDJ4
MAP1LC3A
68
LLPS-Mam-2304
ENSMMUG00000004122.3
P57786
MAPT
69
LLPS-Mam-0479
ENSMMUG00000010433.3
F6PK87
NBR1
70
LLPS-Mam-4490
ENSMMUG00000019749.3
A0A1D5Q0S8
NPHS1
71
LLPS-Mam-1500
ENSMMUG00000001993.3
A0A1D5R0K3
NUP153
72
LLPS-Mam-1348
ENSMMUG00000044817.1
F6ZN69
NUP62
73
LLPS-Mam-3728
ENSMMUG00000003950.3
H9FV00
NUP98
74
LLPS-Mam-1121
ENSMMUG00000017786.3
F7EU16
PABPC1
75
LLPS-Mam-0649
ENSMMUG00000017306.3
F7HSC1
PLK1
76
LLPS-Mam-4062
ENSMMUG00000011392.3
F6Z2V5
PNPLA6
77
LLPS-Mam-1609
ENSMMUG00000023620.3
A0A1D5RJ13
POLR2A
78
LLPS-Mam-3742
ENSMMUG00000010406.3
F7D386
PRKAA2
79
LLPS-Mam-2924
ENSMMUG00000003029.3
A0A1D5RAB9
PRMT1
80
LLPS-Mam-2603
ENSMMUG00000020262.3
F6XYS7
PSPC1
81
LLPS-Mam-2400
ENSMMUG00000016450.3
A0A1D5QCD7
PTBP1
82
LLPS-Mam-0854
ENSMMUG00000012486.3
I0FG12
RARA
83
LLPS-Mam-2759
ENSMMUG00000003458.3
A0A1D5RKL3
RBFOX1
84
LLPS-Mam-2211
ENSMMUG00000020363.3
G7NC47
RBM14
85
LLPS-Mam-1717
ENSMMUG00000005072.3
A0A1D5R2X3
RPL5
86
LLPS-Mam-4003
ENSMMUG00000020341.3
F7G6C1
SGO1
87
LLPS-Mam-3323
ENSMMUG00000005588.3
A0A1D5QJC4
SHANK3
88
LLPS-Mam-4434
ENSMMUG00000020575.3
F6SW16
SOS1
89
LLPS-Mam-2445
ENSMMUG00000021055.3
F7GSB8
SQSTM1
90
LLPS-Mam-0944
ENSMMUG00000011420.3
F6VRW8
SYN1
91
LLPS-Mam-3857
ENSMMUG00000001120.3
F6TA37
SYN2
92
LLPS-Mam-3337
ENSMMUG00000010659.3
A0A1D5Q7A3
SYNGAP1
93
LLPS-Mam-2037
ENSMMUG00000047780.1
A0A1D5QTB3
TAF15
94
LLPS-Mam-0219
ENSMMUG00000007456.3
F7A993
TARDBP
95
LLPS-Mam-1809
ENSMMUG00000001126.3
A0A1D5R335
TIA1
96
LLPS-Mam-0715
ENSMMUG00000001472.3
F7BJ46
TIAL1
97
LLPS-Mam-0922
ENSMMUG00000020923.3
A0A1D5QQR3
TNPO1
98
LLPS-Mam-2945
ENSMMUG00000021345.3
F6XNM1
TNRC6B
99
LLPS-Mam-4165
ENSMMUG00000008639.3
P56424
TP53
100
LLPS-Mam-0274
ENSMMUG00000009788.3
F6Y0X7
TUBA1A
101
LLPS-Mam-4243
ENSMMUG00000042087.1
A0A1D5QRK1
UBQLN2
102
LLPS-Mam-3958
ENSMMUG00000016709.3
F6VEF6
UBXN6
103
LLPS-Mam-3100
ENSMMUG00000029011.2
H9EX76
UBXN8
104
LLPS-Mam-1699
ENSMMUG00000011544.3
A0A1D5RB13
WASL
105
LLPS-Mam-1036
ENSMMUG00000006941.3
F7E1H2
XPO1
106
LLPS-Mam-4460
ENSMMUG00000016875.3
F7BQE6
ZNF207