Xenopus tropicalis      DNA damage foci


※ DNA damage foci introduction

    DNA damage response proteins such as γH2AX, ATM, 53BP1, RAD51, and the MRE11/RAD50/NBS1 complex, that accumulate and/or are modified in the vicinity of a chromosomal DNA double-strand break to form microscopically visible, subnuclear foci called DNA damage foci, also called (ionizing) radiation‐induced foci (IRIF or RIF) or DNA repair foci. The discovery of DNA damage foci has opened a new dimension to the field of DNA damage signaling. Analysis of the spatiotemporal dynamics of DSB induction and repair in situ or even in live cells has now become a standard method in many different fields (1).

Reference
1. Rothkamm, K., Barnard, S., Moquet, J., Ellender, M., Rana, Z., & Burdak-Rothkamm, S. (2015) DNA damage foci: Meaning and significance. Environ Mol Mutagen, 56(6), 491-504. PMID: 25773265


There are 9 genes.  Reviewed (0 or Unreviewed (9

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Xet-0413
ENSXETG00000032616.1
F6Q591
2
LLPS-Xet-0621
ENSXETG00000014471.4
F6V060
atm
3
LLPS-Xet-2158
ENSXETG00000000183.3
F6RYH9
atmin
4
LLPS-Xet-0581
ENSXETG00000000617.3
F7DU67
atr
5
LLPS-Xet-1212
ENSXETG00000001951.3
Q28EL3
fus
6
LLPS-Xet-0252
ENSXETG00000021561.1
F6RBT4
LOC100487455
7
LLPS-Xet-2145
ENSXETG00000006986.3
F6SPI9
rad50
8
LLPS-Xet-1829
ENSXETG00000015951.3
F6ZKW7
rad51
9
LLPS-Xet-2727
ENSXETG00000015007.3
F7EFV3
rbm45