Physcomitrella patens      DNA damage foci


※ DNA damage foci introduction

    DNA damage response proteins such as γH2AX, ATM, 53BP1, RAD51, and the MRE11/RAD50/NBS1 complex, that accumulate and/or are modified in the vicinity of a chromosomal DNA double-strand break to form microscopically visible, subnuclear foci called DNA damage foci, also called (ionizing) radiation‐induced foci (IRIF or RIF) or DNA repair foci. The discovery of DNA damage foci has opened a new dimension to the field of DNA damage signaling. Analysis of the spatiotemporal dynamics of DSB induction and repair in situ or even in live cells has now become a standard method in many different fields (1).

Reference
1. Rothkamm, K., Barnard, S., Moquet, J., Ellender, M., Rana, Z., & Burdak-Rothkamm, S. (2015) DNA damage foci: Meaning and significance. Environ Mol Mutagen, 56(6), 491-504. PMID: 25773265


There are 5 genes.  Reviewed (0 or Unreviewed (5

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Php-1969
Pp3c2_23700
A0A2K1L2S2
ATM
2
LLPS-Php-2301
Pp3c1_20230
A0A2K1L8X6
PHYPA_000878
3
LLPS-Php-0106
Pp3c6_3460
A0A2K1KE63
PHYPA_008445
4
LLPS-Php-1082
Pp3c9_15240
A0A2K1K3A5
PHYPA_012736
5
LLPS-Php-0500
Pp3c7_7920
Q93W51
rad51B