※ DNA damage foci introduction

    DNA damage response proteins such as γH2AX, ATM, 53BP1, RAD51, and the MRE11/RAD50/NBS1 complex, that accumulate and/or are modified in the vicinity of a chromosomal DNA double-strand break to form microscopically visible, subnuclear foci called DNA damage foci, also called (ionizing) radiation‐induced foci (IRIF or RIF) or DNA repair foci. The discovery of DNA damage foci has opened a new dimension to the field of DNA damage signaling. Analysis of the spatiotemporal dynamics of DSB induction and repair in situ or even in live cells has now become a standard method in many different fields (1).

Reference
1. Rothkamm, K., Barnard, S., Moquet, J., Ellender, M., Rana, Z., & Burdak-Rothkamm, S. (2015) DNA damage foci: Meaning and significance. Environ Mol Mutagen, 56(6), 491-504. PMID: 25773265

  Reviewed (0)  or Unreviewed (12) 

No.	Status	DrLLPS ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		LLPS-Pat-1650	ENSPTRG00000004250.6	H2RAN4	ATM
2		LLPS-Pat-2444	ENSPTRG00000008384.4	H2RHJ0	ATMIN
3		LLPS-Pat-4125	ENSPTRG00000015483.7	K7DR10	ATR
4		LLPS-Pat-1614	ENSPTRG00000008038.6	H2RA80	FUS
5		LLPS-Pat-0975	ENSPTRG00000004369.4	K6ZAK5	H2AFX
6		LLPS-Pat-1168	ENSPTRG00000044722.1	K7D1J2	HDAC1
7		LLPS-Pat-4050	ENSPTRG00000017938.7	H2R1M7	MDC1
8		LLPS-Pat-0523	ENSPTRG00000020229.5	H2R3C3	PRKDC
9		LLPS-Pat-2485	ENSPTRG00000017218.5	H2QRG6	RAD50
10		LLPS-Pat-3187	ENSPTRG00000006926.5	A0A2J8QDL2	RAD51
11		LLPS-Pat-4578	ENSPTRG00000012686.4	H2QJ20	RBM45
12		LLPS-Pat-3605	ENSPTRG00000006994.5	A0A2I3RS52	TP53BP1