Otolemur garnettii      DNA damage foci


※ DNA damage foci introduction

    DNA damage response proteins such as γH2AX, ATM, 53BP1, RAD51, and the MRE11/RAD50/NBS1 complex, that accumulate and/or are modified in the vicinity of a chromosomal DNA double-strand break to form microscopically visible, subnuclear foci called DNA damage foci, also called (ionizing) radiation‐induced foci (IRIF or RIF) or DNA repair foci. The discovery of DNA damage foci has opened a new dimension to the field of DNA damage signaling. Analysis of the spatiotemporal dynamics of DSB induction and repair in situ or even in live cells has now become a standard method in many different fields (1).

Reference
1. Rothkamm, K., Barnard, S., Moquet, J., Ellender, M., Rana, Z., & Burdak-Rothkamm, S. (2015) DNA damage foci: Meaning and significance. Environ Mol Mutagen, 56(6), 491-504. PMID: 25773265


There are 11 genes.  Reviewed (0 or Unreviewed (11

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Otg-1308
ENSOGAG00000031397.1
H0XW94
2
LLPS-Otg-2349
ENSOGAG00000029620.1
H0XYP1
3
LLPS-Otg-2150
ENSOGAG00000017247.2
H0XH60
ATM
4
LLPS-Otg-1031
ENSOGAG00000000171.2
H0WFW3
ATR
5
LLPS-Otg-2980
ENSOGAG00000025135.1
H0XQR1
H2AFX
6
LLPS-Otg-1104
ENSOGAG00000005709.2
H0WSN3
HDAC1
7
LLPS-Otg-3536
ENSOGAG00000026246.1
H0XQP0
MDC1
8
LLPS-Otg-3041
ENSOGAG00000000362.2
H0WG96
PRKDC
9
LLPS-Otg-4514
ENSOGAG00000015497.2
B5FW66
RAD50
10
LLPS-Otg-0632
ENSOGAG00000015195.2
H0XCS0
RBM45
11
LLPS-Otg-4041
ENSOGAG00000000130.2
H0WFT2
TP53BP1