Monodelphis domestica      DNA damage foci


※ DNA damage foci introduction

    DNA damage response proteins such as γH2AX, ATM, 53BP1, RAD51, and the MRE11/RAD50/NBS1 complex, that accumulate and/or are modified in the vicinity of a chromosomal DNA double-strand break to form microscopically visible, subnuclear foci called DNA damage foci, also called (ionizing) radiation‐induced foci (IRIF or RIF) or DNA repair foci. The discovery of DNA damage foci has opened a new dimension to the field of DNA damage signaling. Analysis of the spatiotemporal dynamics of DSB induction and repair in situ or even in live cells has now become a standard method in many different fields (1).

Reference
1. Rothkamm, K., Barnard, S., Moquet, J., Ellender, M., Rana, Z., & Burdak-Rothkamm, S. (2015) DNA damage foci: Meaning and significance. Environ Mol Mutagen, 56(6), 491-504. PMID: 25773265


There are 9 genes.  Reviewed (0 or Unreviewed (9

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Mod-3451
ENSMODG00000010246.3
F6W6L3
2
LLPS-Mod-0875
ENSMODG00000014639.3
F6YNZ6
ATM
3
LLPS-Mod-3167
ENSMODG00000015266.2
F6U326
ATMIN
4
LLPS-Mod-2874
ENSMODG00000021237.3
F6TZV8
ATR
5
LLPS-Mod-0316
ENSMODG00000001889.3
F6WGL5
FUS
6
LLPS-Mod-1584
ENSMODG00000013947.3
F6RT86
RAD50
7
LLPS-Mod-0210
ENSMODG00000000268.3
F6WB93
RAD51
8
LLPS-Mod-1957
ENSMODG00000009742.3
F6X9L0
RBM45
9
LLPS-Mod-2428
ENSMODG00000017806.3
F6ZY23
TP53BP1