Macaca mulatta      DNA damage foci


※ DNA damage foci introduction

    DNA damage response proteins such as γH2AX, ATM, 53BP1, RAD51, and the MRE11/RAD50/NBS1 complex, that accumulate and/or are modified in the vicinity of a chromosomal DNA double-strand break to form microscopically visible, subnuclear foci called DNA damage foci, also called (ionizing) radiation‐induced foci (IRIF or RIF) or DNA repair foci. The discovery of DNA damage foci has opened a new dimension to the field of DNA damage signaling. Analysis of the spatiotemporal dynamics of DSB induction and repair in situ or even in live cells has now become a standard method in many different fields (1).

Reference
1. Rothkamm, K., Barnard, S., Moquet, J., Ellender, M., Rana, Z., & Burdak-Rothkamm, S. (2015) DNA damage foci: Meaning and significance. Environ Mol Mutagen, 56(6), 491-504. PMID: 25773265


There are 12 genes.  Reviewed (0 or Unreviewed (12

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Mam-0882
ENSMMUG00000004153.3
F6ZIB3
ATM
2
LLPS-Mam-4075
ENSMMUG00000013086.3
A0A1D5QHW0
ATMIN
3
LLPS-Mam-3549
ENSMMUG00000007927.3
F7HT00
ATR
4
LLPS-Mam-3324
ENSMMUG00000019637.3
F6T5U5
FUS
5
LLPS-Mam-2123
ENSMMUG00000044496.1
A0A1D5Q5B3
H2AFX
6
LLPS-Mam-0862
ENSMMUG00000009948.3
F6RIU8
HDAC1
7
LLPS-Mam-1159
ENSMMUG00000023685.3
F7HCZ1
MDC1
8
LLPS-Mam-1342
ENSMMUG00000015347.3
F6SP41
PRKDC
9
LLPS-Mam-4398
ENSMMUG00000003130.3
F7DGI4
RAD50
10
LLPS-Mam-1537
ENSMMUG00000004579.3
A0A1D5QVN1
RAD51
11
LLPS-Mam-3333
ENSMMUG00000002013.3
F6UTG6
RBM45
12
LLPS-Mam-0021
ENSMMUG00000017078.3
F6VX15
TP53BP1