Loxodonta africana      DNA damage foci


※ DNA damage foci introduction

    DNA damage response proteins such as γH2AX, ATM, 53BP1, RAD51, and the MRE11/RAD50/NBS1 complex, that accumulate and/or are modified in the vicinity of a chromosomal DNA double-strand break to form microscopically visible, subnuclear foci called DNA damage foci, also called (ionizing) radiation‐induced foci (IRIF or RIF) or DNA repair foci. The discovery of DNA damage foci has opened a new dimension to the field of DNA damage signaling. Analysis of the spatiotemporal dynamics of DSB induction and repair in situ or even in live cells has now become a standard method in many different fields (1).

Reference
1. Rothkamm, K., Barnard, S., Moquet, J., Ellender, M., Rana, Z., & Burdak-Rothkamm, S. (2015) DNA damage foci: Meaning and significance. Environ Mol Mutagen, 56(6), 491-504. PMID: 25773265


There are 11 genes.  Reviewed (0 or Unreviewed (11

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Loa-0975
ENSLAFG00000011517.3
G3T7P6
2
LLPS-Loa-1272
ENSLAFG00000008182.4
G3T1D5
ATM
3
LLPS-Loa-1567
ENSLAFG00000004383.3
G3SU59
ATMIN
4
LLPS-Loa-1553
ENSLAFG00000015442.4
G3TF68
ATR
5
LLPS-Loa-0829
ENSLAFG00000001643.2
G3SNY8
FUS
6
LLPS-Loa-2283
ENSLAFG00000004870.2
G3SV40
HDAC1
7
LLPS-Loa-4478
ENSLAFG00000017310.4
G3TIN2
MDC1
8
LLPS-Loa-2890
ENSLAFG00000009764.3
G3T4B6
RAD50
9
LLPS-Loa-1315
ENSLAFG00000008748.2
G3T2F7
RAD51
10
LLPS-Loa-1986
ENSLAFG00000007464.2
G3T022
RBM45
11
LLPS-Loa-0347
ENSLAFG00000001197.4
G3SN60
TP53BP1