Ictidomys tridecemlineatus      DNA damage foci


※ DNA damage foci introduction

    DNA damage response proteins such as γH2AX, ATM, 53BP1, RAD51, and the MRE11/RAD50/NBS1 complex, that accumulate and/or are modified in the vicinity of a chromosomal DNA double-strand break to form microscopically visible, subnuclear foci called DNA damage foci, also called (ionizing) radiation‐induced foci (IRIF or RIF) or DNA repair foci. The discovery of DNA damage foci has opened a new dimension to the field of DNA damage signaling. Analysis of the spatiotemporal dynamics of DSB induction and repair in situ or even in live cells has now become a standard method in many different fields (1).

Reference
1. Rothkamm, K., Barnard, S., Moquet, J., Ellender, M., Rana, Z., & Burdak-Rothkamm, S. (2015) DNA damage foci: Meaning and significance. Environ Mol Mutagen, 56(6), 491-504. PMID: 25773265


There are 8 genes.  Reviewed (0 or Unreviewed (8

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Ict-2539
ENSSTOG00000004418.3
I3M4C5
ATM
2
LLPS-Ict-3732
ENSSTOG00000007376.3
I3M9K6
ATMIN
3
LLPS-Ict-1520
ENSSTOG00000021792.2
I3MUH2
ATR
4
LLPS-Ict-1024
ENSSTOG00000014429.1
I3MMW9
H2AFX
5
LLPS-Ict-2429
ENSSTOG00000009784.3
I3MEE6
PRKDC
6
LLPS-Ict-3977
ENSSTOG00000009876.3
I3MEF5
Rad50
7
LLPS-Ict-3172
ENSSTOG00000002708.3
I3M0Y4
RBM45
8
LLPS-Ict-1377
ENSSTOG00000006966.3
I3M8Y1
TP53BP1