Homo sapiens      DNA damage foci


※ DNA damage foci introduction

    DNA damage response proteins such as γH2AX, ATM, 53BP1, RAD51, and the MRE11/RAD50/NBS1 complex, that accumulate and/or are modified in the vicinity of a chromosomal DNA double-strand break to form microscopically visible, subnuclear foci called DNA damage foci, also called (ionizing) radiation‐induced foci (IRIF or RIF) or DNA repair foci. The discovery of DNA damage foci has opened a new dimension to the field of DNA damage signaling. Analysis of the spatiotemporal dynamics of DSB induction and repair in situ or even in live cells has now become a standard method in many different fields (1).

Reference
1. Rothkamm, K., Barnard, S., Moquet, J., Ellender, M., Rana, Z., & Burdak-Rothkamm, S. (2015) DNA damage foci: Meaning and significance. Environ Mol Mutagen, 56(6), 491-504. PMID: 25773265


There are 12 genes.  Reviewed (12 or Unreviewed (0

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Hos-0566
ENSG00000149311.18
Q13315
ATM
2
LLPS-Hos-1515
ENSG00000166454.9
O43313
ATMIN
3
LLPS-Hos-1389
ENSG00000175054.14
Q13535
ATR
4
LLPS-Hos-1390
ENSG00000089280.18
P35637
FUS
5
LLPS-Hos-2828
ENSG00000188486.3
P16104
H2AFX
6
LLPS-Hos-0070
ENSG00000116478.11
Q13547
HDAC1
7
LLPS-Hos-1854
ENSG00000137337.14
Q14676
MDC1
8
LLPS-Hos-2471
ENSG00000253729.7
P78527
PRKDC
9
LLPS-Hos-4661
ENSG00000113522.13
Q92878
RAD50
10
LLPS-Hos-0179
ENSG00000051180.16
Q06609
RAD51
11
LLPS-Hos-2305
ENSG00000155636.14
Q8IUH3
RBM45
12
LLPS-Hos-1940
ENSG00000067369.13
Q12888
TP53BP1