Danio rerio      DNA damage foci


※ DNA damage foci introduction

    DNA damage response proteins such as γH2AX, ATM, 53BP1, RAD51, and the MRE11/RAD50/NBS1 complex, that accumulate and/or are modified in the vicinity of a chromosomal DNA double-strand break to form microscopically visible, subnuclear foci called DNA damage foci, also called (ionizing) radiation‐induced foci (IRIF or RIF) or DNA repair foci. The discovery of DNA damage foci has opened a new dimension to the field of DNA damage signaling. Analysis of the spatiotemporal dynamics of DSB induction and repair in situ or even in live cells has now become a standard method in many different fields (1).

Reference
1. Rothkamm, K., Barnard, S., Moquet, J., Ellender, M., Rana, Z., & Burdak-Rothkamm, S. (2015) DNA damage foci: Meaning and significance. Environ Mol Mutagen, 56(6), 491-504. PMID: 25773265


There are 9 genes.  Reviewed (0 or Unreviewed (9

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Dar-0356
ENSDARG00000002385.10
F1QJB6
atm
2
LLPS-Dar-3484
ENSDARG00000068601.6
A5WW46
atmin
3
LLPS-Dar-0619
ENSDARG00000079625.6
F1QMM7
atr
4
LLPS-Dar-3633
ENSDARG00000086764.4
E7FA74
mdc1
5
LLPS-Dar-1385
ENSDARG00000075083.6
E7F4J7
prkdc
6
LLPS-Dar-1246
ENSDARG00000038917.9
F8W411
rad50
7
LLPS-Dar-1797
ENSDARG00000041411.7
Q5TYR1
rad51
8
LLPS-Dar-1379
ENSDARG00000063731.7
B0S522
rbm45
9
LLPS-Dar-2474
ENSDARG00000079000.5
F1RBE6
tp53bp1