Cavia porcellus      DNA damage foci


※ DNA damage foci introduction

    DNA damage response proteins such as γH2AX, ATM, 53BP1, RAD51, and the MRE11/RAD50/NBS1 complex, that accumulate and/or are modified in the vicinity of a chromosomal DNA double-strand break to form microscopically visible, subnuclear foci called DNA damage foci, also called (ionizing) radiation‐induced foci (IRIF or RIF) or DNA repair foci. The discovery of DNA damage foci has opened a new dimension to the field of DNA damage signaling. Analysis of the spatiotemporal dynamics of DSB induction and repair in situ or even in live cells has now become a standard method in many different fields (1).

Reference
1. Rothkamm, K., Barnard, S., Moquet, J., Ellender, M., Rana, Z., & Burdak-Rothkamm, S. (2015) DNA damage foci: Meaning and significance. Environ Mol Mutagen, 56(6), 491-504. PMID: 25773265


There are 10 genes.  Reviewed (0 or Unreviewed (10

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Cap-0250
ENSCPOG00000001787.4
H0UX17
2
LLPS-Cap-0760
ENSCPOG00000010997.4
H0VI73
ATM
3
LLPS-Cap-0310
ENSCPOG00000020155.2
H0W3T1
ATMIN
4
LLPS-Cap-4418
ENSCPOG00000007001.4
H0V935
ATR
5
LLPS-Cap-1273
ENSCPOG00000038302.1
A0A286XTI8
FUS
6
LLPS-Cap-3488
ENSCPOG00000007757.4
H0VAT3
HDAC1
7
LLPS-Cap-0968
ENSCPOG00000013944.4
H0VPX0
PRKDC
8
LLPS-Cap-3287
ENSCPOG00000002226.4
H0UY19
Rad50
9
LLPS-Cap-1639
ENSCPOG00000014105.4
H0VQ96
Rad51
10
LLPS-Cap-1234
ENSCPOG00000000684.4
H0UUG5
RBM45