Canis familiaris      DNA damage foci


※ DNA damage foci introduction

    DNA damage response proteins such as γH2AX, ATM, 53BP1, RAD51, and the MRE11/RAD50/NBS1 complex, that accumulate and/or are modified in the vicinity of a chromosomal DNA double-strand break to form microscopically visible, subnuclear foci called DNA damage foci, also called (ionizing) radiation‐induced foci (IRIF or RIF) or DNA repair foci. The discovery of DNA damage foci has opened a new dimension to the field of DNA damage signaling. Analysis of the spatiotemporal dynamics of DSB induction and repair in situ or even in live cells has now become a standard method in many different fields (1).

Reference
1. Rothkamm, K., Barnard, S., Moquet, J., Ellender, M., Rana, Z., & Burdak-Rothkamm, S. (2015) DNA damage foci: Meaning and significance. Environ Mol Mutagen, 56(6), 491-504. PMID: 25773265


There are 12 genes.  Reviewed (0 or Unreviewed (12

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Caf-2749
ENSCAFG00000014454.4
F1PEL7
ATM
2
LLPS-Caf-0599
ENSCAFG00000020016.4
J9P3H8
ATMIN
3
LLPS-Caf-1280
ENSCAFG00000007863.4
E2QXA4
ATR
4
LLPS-Caf-0611
ENSCAFG00000016862.4
F1PBJ4
FUS
5
LLPS-Caf-1834
ENSCAFG00000012332.2
E2RNB0
H2AFX
6
LLPS-Caf-0836
ENSCAFG00000010597.4
J9NUI0
HDAC1
7
LLPS-Caf-3846
ENSCAFG00000000442.4
F6UVB9
MDC1
8
LLPS-Caf-2841
ENSCAFG00000006555.3
F1Q3H1
PRKDC
9
LLPS-Caf-0004
ENSCAFG00000000867.4
F6UTT0
RAD50
10
LLPS-Caf-0869
ENSCAFG00000009220.2
Q8MKI8
RAD51
11
LLPS-Caf-1886
ENSCAFG00000013640.3
F1PYP3
RBM45
12
LLPS-Caf-2394
ENSCAFG00000012508.4
F1PRR6
TP53BP1