Pelodiscus sinensis      Cleavage body


※ Cleavage body introduction

    Cleavage bodies is a kind of nuclear PMLO (proteinaceous membrane-less organelles) located in Nucleus, It contains no DNA or RNA and it is fluid shaped as a spherical, it is associated with RNA metabolism, potentially serves as storage/assembly sites for proteins involved in transcription, splicing 3’-end processing of pre-mRNAs, and RNA degradation (1). They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 3 genes.  Reviewed (0 or Unreviewed (3

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Pes-1839
ENSPSIG00000006289.1
K7FFI7
CPSF2
2
LLPS-Pes-1678
ENSPSIG00000003482.1
K7F6J8
CSTF2
3
LLPS-Pes-2091
ENSPSIG00000012292.1
K7G071
DDX1