Verticillium dahliae      Cajal body


※ Cajal body introduction

    Cajal bodies is a kind of non-membrane-bound nuclear bodies, formation of such sub-organelles usually involves dynamic processes, which can move within the nucleoplasm except when transiently immobilized through interaction with chromatin (1). The Cajal body has been suggested to be associated with telomere maintenance and maturation of the splicing machinery and processing of histone mRNA (2;3), it is rich in ribonucleoprotein (RNP) complexes and characterized by the marker protein coilin that interacts with many factors and thereby serves as a platform for the assembly of Cajal bodies (1). WRAP53β has been demonstrated to be an essential Cajal Body Component, it guides SMN across the cell to Cajal Bodies, and phosphorylation of WRAP53β by ATM promotes its involvement in the DNA damage response (4). besides, Fam118 is a newly identified component of Cajal bodies that is required for Cajal body formation (5). Defects in Cajal body formation are linked to impaired cell proliferation and splicing (6). In fact, Cajal bodies are not essential in telomerase function and telomere elongation ,whereas certain Cajal body factors such as WRAP53β clearly play important roles in telomere homeostasis (1).

References
1. Henriksson, S., & Farnebo, M. (2015) On the road with WRAP53beta: guardian of Cajal bodies and genome integrity. Front Genet, 6, 91. PMID: 25852739
2. Machyna, M., Heyn, P., & Neugebauer, K. M. (2013) Cajal bodies: where form meets function. Wiley Interdiscip Rev RNA, 4(1), 17-34. PMID: 23042601
3. Hutten, S., Chachami, G., Winter, U., Melchior, F., & Lamond, A. I. (2014) A role for the Cajal-body-associated SUMO isopeptidase USPL1 in snRNA transcription mediated by RNA polymerase II. J. Cell. Sci., 127(Pt 5), 1065-1078. PMID: 24413172
4. Coucoravas, C., Dhanjal, S., Henriksson, S., Bohm, S., & Farnebo, M. (2017) Phosphorylation of the Cajal body protein WRAP53beta by ATM promotes its involvement in the DNA damage response. RNA Biol., 14(6), 804-813. PMID: 27715493
5. Li, Y., Fong, K. W., Tang, M., Han, X., Gong, Z., Ma, W, Chen, J. (2014) Fam118B, a newly identified component of Cajal bodies, is required for Cajal body formation, snRNP biogenesis and cell viability. J. Cell Sci., 127(Pt 9), 2029-2039. PMID:24569877
6. Lemm, I., Girard, C., Kuhn, A. N., Watkins, N. J., Schneider, M., Bordonne, R., & Luhrmann, R. (2006) Ongoing U snRNP biogenesis is required for the integrity of Cajal bodies. Mol. Biol. Cell, 17(7), 3221-3231. PMID:16687569


There are 14 genes.  Reviewed (0 or Unreviewed (14

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Ved-1414
VDAG_00399
G2WS66
VDAG_00399
2
LLPS-Ved-0549
VDAG_00538
G2WQ96
VDAG_00538
3
LLPS-Ved-0267
VDAG_00781
G2WR00
VDAG_00781
4
LLPS-Ved-0190
VDAG_02170
G2WV29
VDAG_02170
5
LLPS-Ved-0928
VDAG_03032
G2X009
VDAG_03032
6
LLPS-Ved-0614
VDAG_03182
G2WYU0
VDAG_03182
7
LLPS-Ved-0331
VDAG_04610
G2X3M3
VDAG_04610
8
LLPS-Ved-1346
VDAG_06186
G2X8P5
VDAG_06186
9
LLPS-Ved-1310
VDAG_06693
G2X961
VDAG_06693
10
LLPS-Ved-0650
VDAG_07006
G2XAA3
VDAG_07006
11
LLPS-Ved-0655
VDAG_07092
G2XAI9
VDAG_07092
12
LLPS-Ved-0006
VDAG_08913
G2XGC6
VDAG_08913
13
LLPS-Ved-0800
VDAG_10000
G2XIL8
VDAG_10000
14
LLPS-Ved-0346
VDAG_10033
G2XIQ1
VDAG_10033