※ Cajal body introduction

    Cajal bodies is a kind of non-membrane-bound nuclear bodies, formation of such sub-organelles usually involves dynamic processes, which can move within the nucleoplasm except when transiently immobilized through interaction with chromatin (1). The Cajal body has been suggested to be associated with telomere maintenance and maturation of the splicing machinery and processing of histone mRNA (2;3), it is rich in ribonucleoprotein (RNP) complexes and characterized by the marker protein coilin that interacts with many factors and thereby serves as a platform for the assembly of Cajal bodies (1). WRAP53β has been demonstrated to be an essential Cajal Body Component, it guides SMN across the cell to Cajal Bodies, and phosphorylation of WRAP53β by ATM promotes its involvement in the DNA damage response (4). besides, Fam118 is a newly identified component of Cajal bodies that is required for Cajal body formation (5). Defects in Cajal body formation are linked to impaired cell proliferation and splicing (6). In fact, Cajal bodies are not essential in telomerase function and telomere elongation ,whereas certain Cajal body factors such as WRAP53β clearly play important roles in telomere homeostasis (1).

References
1. Henriksson, S., & Farnebo, M. (2015) On the road with WRAP53beta: guardian of Cajal bodies and genome integrity. Front Genet, 6, 91. PMID: 25852739
2. Machyna, M., Heyn, P., & Neugebauer, K. M. (2013) Cajal bodies: where form meets function. Wiley Interdiscip Rev RNA, 4(1), 17-34. PMID: 23042601
3. Hutten, S., Chachami, G., Winter, U., Melchior, F., & Lamond, A. I. (2014) A role for the Cajal-body-associated SUMO isopeptidase USPL1 in snRNA transcription mediated by RNA polymerase II. J. Cell. Sci., 127(Pt 5), 1065-1078. PMID: 24413172
4. Coucoravas, C., Dhanjal, S., Henriksson, S., Bohm, S., & Farnebo, M. (2017) Phosphorylation of the Cajal body protein WRAP53beta by ATM promotes its involvement in the DNA damage response. RNA Biol., 14(6), 804-813. PMID: 27715493
5. Li, Y., Fong, K. W., Tang, M., Han, X., Gong, Z., Ma, W, Chen, J. (2014) Fam118B, a newly identified component of Cajal bodies, is required for Cajal body formation, snRNP biogenesis and cell viability. J. Cell Sci., 127(Pt 9), 2029-2039. PMID:24569877
6. Lemm, I., Girard, C., Kuhn, A. N., Watkins, N. J., Schneider, M., Bordonne, R., & Luhrmann, R. (2006) Ongoing U snRNP biogenesis is required for the integrity of Cajal bodies. Mol. Biol. Cell, 17(7), 3221-3231. PMID:16687569

  Reviewed (0)  or Unreviewed (19) 

No.	Status	DrLLPS ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		LLPS-Sei-0694	SETIT_021730mg
2		LLPS-Sei-1369	SETIT_031706mg	K3ZYM4	101752518
3		LLPS-Sei-0905	SETIT_022494mg	K3Z7H4	101752544
4		LLPS-Sei-0172	SETIT_009873mg	K3Y6N2	101756017
5		LLPS-Sei-0157	SETIT_035807mg	K4AAA0	101759300
6		LLPS-Sei-0007	SETIT_013257mg	K3YG88	101760451
7		LLPS-Sei-0192	SETIT_017895mg	K3YUE9	101762213
8		LLPS-Sei-0146	SETIT_034926mg	K4A7S0	101762445
9		LLPS-Sei-1970	SETIT_017040mg	K3YRZ6	101765841
10		LLPS-Sei-0284	SETIT_011381mg	K3YAY9	101769681
11		LLPS-Sei-1790	SETIT_029706mg	K3ZSX6	101771808
12		LLPS-Sei-1567	SETIT_016960mg	K3YRR6	101772472
13		LLPS-Sei-2515	SETIT_027683mg	K3ZM69	101779175
14		LLPS-Sei-0753	SETIT_014746mg	K3YKH7	101786093
15		LLPS-Sei-0668	SETIT_028775mg	A0A368PXU9	SETIT_2G111900v2
16		LLPS-Sei-0660	SETIT_029271mg	K3ZRP1	SETIT_2G421200v2
17		LLPS-Sei-0633	SETIT_005673mg	A0A368QYN3	SETIT_4G217700v2
18		LLPS-Sei-0149	SETIT_001393mg	A0A368RD90	SETIT_5G374000v2
19		LLPS-Sei-1033	SETIT_036950mg	A0A368SS30	SETIT_9G436100v2