※ Cajal body introduction

    Cajal bodies is a kind of non-membrane-bound nuclear bodies, formation of such sub-organelles usually involves dynamic processes, which can move within the nucleoplasm except when transiently immobilized through interaction with chromatin (1). The Cajal body has been suggested to be associated with telomere maintenance and maturation of the splicing machinery and processing of histone mRNA (2;3), it is rich in ribonucleoprotein (RNP) complexes and characterized by the marker protein coilin that interacts with many factors and thereby serves as a platform for the assembly of Cajal bodies (1). WRAP53β has been demonstrated to be an essential Cajal Body Component, it guides SMN across the cell to Cajal Bodies, and phosphorylation of WRAP53β by ATM promotes its involvement in the DNA damage response (4). besides, Fam118 is a newly identified component of Cajal bodies that is required for Cajal body formation (5). Defects in Cajal body formation are linked to impaired cell proliferation and splicing (6). In fact, Cajal bodies are not essential in telomerase function and telomere elongation ,whereas certain Cajal body factors such as WRAP53β clearly play important roles in telomere homeostasis (1).

References
1. Henriksson, S., & Farnebo, M. (2015) On the road with WRAP53beta: guardian of Cajal bodies and genome integrity. Front Genet, 6, 91. PMID: 25852739
2. Machyna, M., Heyn, P., & Neugebauer, K. M. (2013) Cajal bodies: where form meets function. Wiley Interdiscip Rev RNA, 4(1), 17-34. PMID: 23042601
3. Hutten, S., Chachami, G., Winter, U., Melchior, F., & Lamond, A. I. (2014) A role for the Cajal-body-associated SUMO isopeptidase USPL1 in snRNA transcription mediated by RNA polymerase II. J. Cell. Sci., 127(Pt 5), 1065-1078. PMID: 24413172
4. Coucoravas, C., Dhanjal, S., Henriksson, S., Bohm, S., & Farnebo, M. (2017) Phosphorylation of the Cajal body protein WRAP53beta by ATM promotes its involvement in the DNA damage response. RNA Biol., 14(6), 804-813. PMID: 27715493
5. Li, Y., Fong, K. W., Tang, M., Han, X., Gong, Z., Ma, W, Chen, J. (2014) Fam118B, a newly identified component of Cajal bodies, is required for Cajal body formation, snRNP biogenesis and cell viability. J. Cell Sci., 127(Pt 9), 2029-2039. PMID:24569877
6. Lemm, I., Girard, C., Kuhn, A. N., Watkins, N. J., Schneider, M., Bordonne, R., & Luhrmann, R. (2006) Ongoing U snRNP biogenesis is required for the integrity of Cajal bodies. Mol. Biol. Cell, 17(7), 3221-3231. PMID:16687569

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No.	Status	DrLLPS ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		LLPS-Sem-1511	SELMODRAFT_121644	D8SPD0	SELMODRAFT_121644
2		LLPS-Sem-1963	SELMODRAFT_124256	D8R2P2	SELMODRAFT_124256
3		LLPS-Sem-0286	SELMODRAFT_140819	D8QSR9	SELMODRAFT_140819
4		LLPS-Sem-0053	SELMODRAFT_145785	D8RDL9	SELMODRAFT_145785
5		LLPS-Sem-1258	SELMODRAFT_146841	D8RG17	SELMODRAFT_146841
6		LLPS-Sem-0513	SELMODRAFT_171051	D8RFP8	SELMODRAFT_171051
7		LLPS-Sem-0505	SELMODRAFT_172852	D8RN07	SELMODRAFT_172852
8		LLPS-Sem-1378	SELMODRAFT_176675	D8R512	SELMODRAFT_176675
9		LLPS-Sem-1059	SELMODRAFT_181868	D8SQL1	SELMODRAFT_181868
10		LLPS-Sem-1023	SELMODRAFT_182680	D8SU25	SELMODRAFT_182680
11		LLPS-Sem-1971	SELMODRAFT_227744	D8RA33	SELMODRAFT_227744
12		LLPS-Sem-0242	SELMODRAFT_231785	D8R4G5	SELMODRAFT_231785
13		LLPS-Sem-0472	SELMODRAFT_233747	D8SDS6	SELMODRAFT_233747
14		LLPS-Sem-1282	SELMODRAFT_233936	D8SFW6	SELMODRAFT_233936
15		LLPS-Sem-0020	SELMODRAFT_236385	D8T867	SELMODRAFT_236385
16		LLPS-Sem-0564	SELMODRAFT_402481	D8QQS6	SELMODRAFT_402481
17		LLPS-Sem-0229	SELMODRAFT_408955	D8R904	SELMODRAFT_408955
18		LLPS-Sem-1577	SELMODRAFT_422911	D8SJY6	SELMODRAFT_422911
19		LLPS-Sem-0481	SELMODRAFT_6302	D8S7H9	SELMODRAFT_6302