※ Cajal body introduction

    Cajal bodies is a kind of non-membrane-bound nuclear bodies, formation of such sub-organelles usually involves dynamic processes, which can move within the nucleoplasm except when transiently immobilized through interaction with chromatin (1). The Cajal body has been suggested to be associated with telomere maintenance and maturation of the splicing machinery and processing of histone mRNA (2;3), it is rich in ribonucleoprotein (RNP) complexes and characterized by the marker protein coilin that interacts with many factors and thereby serves as a platform for the assembly of Cajal bodies (1). WRAP53β has been demonstrated to be an essential Cajal Body Component, it guides SMN across the cell to Cajal Bodies, and phosphorylation of WRAP53β by ATM promotes its involvement in the DNA damage response (4). besides, Fam118 is a newly identified component of Cajal bodies that is required for Cajal body formation (5). Defects in Cajal body formation are linked to impaired cell proliferation and splicing (6). In fact, Cajal bodies are not essential in telomerase function and telomere elongation ,whereas certain Cajal body factors such as WRAP53β clearly play important roles in telomere homeostasis (1).

References
1. Henriksson, S., & Farnebo, M. (2015) On the road with WRAP53beta: guardian of Cajal bodies and genome integrity. Front Genet, 6, 91. PMID: 25852739
2. Machyna, M., Heyn, P., & Neugebauer, K. M. (2013) Cajal bodies: where form meets function. Wiley Interdiscip Rev RNA, 4(1), 17-34. PMID: 23042601
3. Hutten, S., Chachami, G., Winter, U., Melchior, F., & Lamond, A. I. (2014) A role for the Cajal-body-associated SUMO isopeptidase USPL1 in snRNA transcription mediated by RNA polymerase II. J. Cell. Sci., 127(Pt 5), 1065-1078. PMID: 24413172
4. Coucoravas, C., Dhanjal, S., Henriksson, S., Bohm, S., & Farnebo, M. (2017) Phosphorylation of the Cajal body protein WRAP53beta by ATM promotes its involvement in the DNA damage response. RNA Biol., 14(6), 804-813. PMID: 27715493
5. Li, Y., Fong, K. W., Tang, M., Han, X., Gong, Z., Ma, W, Chen, J. (2014) Fam118B, a newly identified component of Cajal bodies, is required for Cajal body formation, snRNP biogenesis and cell viability. J. Cell Sci., 127(Pt 9), 2029-2039. PMID:24569877
6. Lemm, I., Girard, C., Kuhn, A. N., Watkins, N. J., Schneider, M., Bordonne, R., & Luhrmann, R. (2006) Ongoing U snRNP biogenesis is required for the integrity of Cajal bodies. Mol. Biol. Cell, 17(7), 3221-3231. PMID:16687569

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No.	Status	DrLLPS ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		LLPS-Ast-1460	ATEG_00118	Q0D1R6	ATEG_00118
2		LLPS-Ast-0512	ATEG_00593	Q0D0E1	ATEG_00593
3		LLPS-Ast-0163	ATEG_00625	Q0D0A9	ATEG_00625
4		LLPS-Ast-0672	ATEG_01536	Q0CXP8	ATEG_01536
5		LLPS-Ast-1266	ATEG_02383	Q0CVA1	ATEG_02383
6		LLPS-Ast-0332	ATEG_03996	Q0CQN8	ATEG_03996
7		LLPS-Ast-0428	ATEG_04100	Q0CQD4	ATEG_04100
8		LLPS-Ast-0697	ATEG_04347	Q0CPN7	ATEG_04347
9		LLPS-Ast-0791	ATEG_04849	Q0CN85	ATEG_04849
10		LLPS-Ast-0302	ATEG_05757	Q0CKM7	ATEG_05757
11		LLPS-Ast-0031	ATEG_05987	Q0CJZ7	ATEG_05987
12		LLPS-Ast-0830	ATEG_06336	Q0CIZ8	ATEG_06336
13		LLPS-Ast-0381	ATEG_07424	Q0CFW0	ATEG_07424
14		LLPS-Ast-0066	ATEG_07657	Q0CF77	ATEG_07657
15		LLPS-Ast-0207	ATEG_08495	Q0CCT9	ATEG_08495