LLPS-Sac-0170
HST2
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | NAD-dependent protein deacetylase HST2; Homologous to SIR2 protein 2; Regulatory protein SIR2 homolog 2 |
| Gene Name: | HST2, YPL015C, LPA2C |
| Ensembl Gene: | YPL015C |
| Ensembl Protein: | YPL015C_mRNA |
| Organism: | Saccharomyces cerevisiae |
| Taxa ID: | 559292 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Stress granule | "...Here we systematically identified proteins sequestered in Saccharomyces cerevisiae at 46 °C by a SG co‐localization screen and proteomic analysis of insoluble protein fractions." | Saccharomyces cerevisiae | 26484595 |
| Stress granule | "...Here we systematically identified proteins sequestered in Saccharomyces cerevisiae at 46 °C by a SG co‐localization screen and proteomic analysis of insoluble protein fractions. We identified novel SG components including essential aminoacyl‐tRNA synthetases." | Saccharomyces cerevisiae | 26484595 |
| Others | "...Hos2 SPGs also contained Hst2, a Sir2 homologue, and several stress-related proteins, including Set3, Yca1, Hsp26, Hsp43, and some known components of stress granules." | Saccharomyces cerevisiae | 22337769 |
| Nucleolus | Predicted from orthologs | N/A | (View) |
▼ FUNCTION
| NAD-dependent histone deacetylase that is involved in nuclear silencing events. Derepresses subtelomeric silencing and increases repression in nucleolar (rDNA) silencing. Its function is negatively regulated by active nuclear export. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | YPL015C_mRNA | YPL015C_mRNA |
| UniProt | P53686, HST2_YEAST, D6W3Z7 | |
| GeneBank | U33335, AY693204, BK006949, U39063 | AAT93223.1, DAA11413.1, AAA81035.1, AAB68090.1 |
| RefSeq | NM_001183829.1 | NP_015310.1 |
| Entrez | 856092 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSVSTASTEM SVRKIAAHMK SNPNAKVIFM VGAGISTSCG IPDFRSPGTG LYHNLARLKL 60 61 PYPEAVFDVD FFQSDPLPFY TLAKELYPGN FRPSKFHYLL KLFQDKDVLK RVYTQNIDTL 120 121 ERQAGVKDDL IIEAHGSFAH CHCIGCGKVY PPQVFKSKLA EHPIKDFVKC DVCGELVKPA 180 181 IVFFGEDLPD SFSETWLNDS EWLREKITTS GKHPQQPLVI VVGTSLAVYP FASLPEEIPR 240 241 KVKRVLCNLE TVGDFKANKR PTDLIVHQYS DEFAEQLVEE LGWQEDFEKI LTAQGGMGDN 300 301 SKEQLLEIVH DLENLSLDQS EHESADKKDK KLQRLNGHDS DEDGASNSSS SQKAAKE 357 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTCTGTTT CTACCGCCTC TACAGAGATG TCGGTTAGGA AGATCGCTGC TCATATGAAA 60 61 AGCAACCCCA ACGCTAAAGT AATCTTTATG GTGGGTGCCG GGATATCCAC TTCTTGTGGG 120 121 ATACCAGACT TCCGATCTCC GGGAACTGGC CTGTACCATA ACTTGGCCAG GTTGAAGTTG 180 181 CCGTACCCTG AAGCAGTGTT CGATGTCGAT TTTTTCCAAT CGGATCCTTT GCCATTTTAC 240 241 ACTTTGGCTA AAGAGTTGTA TCCCGGAAAT TTCAGACCTT CTAAGTTTCA CTATCTTTTG 300 301 AAATTGTTTC AAGACAAAGA CGTTTTGAAG AGAGTATATA CCCAGAATAT AGACACTTTA 360 361 GAAAGACAGG CCGGTGTTAA GGATGATCTG ATCATCGAGG CCCATGGCAG TTTTGCTCAC 420 421 TGTCATTGTA TCGGATGTGG TAAAGTTTAT CCCCCACAGG TTTTCAAATC CAAGCTGGCA 480 481 GAGCATCCTA TAAAGGATTT TGTCAAGTGT GATGTGTGCG GTGAACTGGT AAAGCCGGCA 540 541 ATAGTTTTTT TTGGCGAAGA TCTACCGGAT TCCTTTTCGG AAACTTGGTT AAACGATTCA 600 601 GAGTGGCTTC GTGAAAAAAT CACGACATCT GGAAAACATC CTCAGCAGCC TCTTGTCATC 660 661 GTCGTTGGCA CCTCACTAGC CGTTTATCCC TTTGCGTCTC TGCCCGAAGA AATTCCTCGA 720 721 AAGGTAAAAA GAGTTCTGTG CAATTTGGAA ACGGTGGGCG ATTTTAAAGC TAACAAGAGG 780 781 CCTACAGATT TAATAGTTCA TCAGTACTCG GATGAGTTTG CCGAGCAACT CGTTGAAGAA 840 841 TTAGGTTGGC AAGAAGATTT CGAAAAGATA CTTACGGCCC AAGGTGGAAT GGGGGATAAC 900 901 TCTAAAGAGC AATTACTTGA AATTGTACAT GATTTAGAGA ATTTGAGTTT GGATCAATCT 960 961 GAACATGAGA GTGCAGACAA GAAGGATAAG AAGCTACAGC GTCTCAATGG CCATGACAGC 1020 1021 GATGAAGATG GAGCAAGCAA CTCCTCTTCT TCACAAAAAG CCGCTAAAGA ATAA 1074 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Nucleus | |
Molecular Function | NAD+ binding | |
Molecular Function | NAD-dependent histone deacetylase activity | |
Molecular Function | NAD-dependent histone deacetylase activity (H4-K16 specific) | |
Molecular Function | Zinc ion binding | |
Biological Process | Chromatin silencing at rDNA | |
Biological Process | Chronological cell aging | |
Biological Process | Histone H4 deacetylation | |
Biological Process | Negative regulation of chromatin silencing at telomere | |
Biological Process | Negative regulation of mitotic recombination |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Asg-0022 | Ashbya gossypii | 54.9 | 9e-113 | 339 |
| LLPS-Sah-1307 | Sarcophilus harrisii | 50.54 | 1e-57 | 192 |
| LLPS-Asni-0922 | Aspergillus niger | 50.39 | 7e-72 | 235 |
| LLPS-Kop-0979 | Komagataella pastoris | 49.25 | 9e-88 | 275 |
| LLPS-Mea-4089 | Mesocricetus auratus | 48.55 | 2e-50 | 178 |
| LLPS-Zyt-0654 | Zymoseptoria tritici | 48.2 | 8e-76 | 243 |
| LLPS-Cogr-1166 | Colletotrichum graminicola | 47.52 | 9e-76 | 249 |
| LLPS-Ved-0450 | Verticillium dahliae | 47.26 | 1e-56 | 194 |
| LLPS-Asn-1007 | Aspergillus nidulans | 47.14 | 5e-76 | 245 |
| LLPS-Dos-0200 | Dothistroma septosporum | 47.0 | 5e-77 | 248 |
| LLPS-Fud-0215 | Fukomys damarensis | 46.73 | 8e-53 | 179 |
| LLPS-Spr-0189 | Sporisorium reilianum | 46.67 | 1e-59 | 204 |
| LLPS-Coo-0428 | Colletotrichum orbiculare | 46.64 | 2e-76 | 251 |
| LLPS-Mao-0429 | Magnaporthe oryzae | 46.62 | 5e-75 | 246 |
| LLPS-Nec-0584 | Neurospora crassa | 46.45 | 2e-71 | 234 |
| LLPS-Asc-0158 | Aspergillus clavatus | 46.45 | 2e-75 | 246 |
| LLPS-Ast-0065 | Aspergillus terreus | 46.43 | 2e-75 | 244 |
| LLPS-Mel-0939 | Melampsora laricipopulina | 46.38 | 6e-69 | 223 |
| LLPS-Dio-4268 | Dipodomys ordii | 46.21 | 1e-68 | 223 |
| LLPS-Crn-0340 | Cryptococcus neoformans | 45.95 | 1e-73 | 241 |
| LLPS-Fuo-0778 | Fusarium oxysporum | 45.8 | 9e-72 | 237 |
| LLPS-Mod-1969 | Monodelphis domestica | 45.8 | 9e-76 | 248 |
| LLPS-Aso-0178 | Aspergillus oryzae | 45.8 | 8e-75 | 243 |
| LLPS-Asf-0437 | Aspergillus flavus | 45.8 | 8e-75 | 243 |
| LLPS-Fuv-0504 | Fusarium verticillioides | 45.8 | 4e-72 | 237 |
| LLPS-Nef-0682 | Neosartorya fischeri | 45.74 | 4e-68 | 226 |
| LLPS-Urm-0351 | Ursus maritimus | 45.65 | 5e-46 | 169 |
| LLPS-Asfu-0515 | Aspergillus fumigatus | 45.59 | 2e-67 | 225 |
| LLPS-Cog-1211 | Colletotrichum gloeosporioides | 45.08 | 3e-73 | 241 |
| LLPS-Ict-2858 | Ictidomys tridecemlineatus | 45.05 | 2e-69 | 224 |
| LLPS-Trv-0640 | Trichoderma virens | 45.04 | 6e-73 | 238 |
| LLPS-Loa-4106 | Loxodonta africana | 45.04 | 1e-68 | 223 |
| LLPS-Lem-0743 | Leptosphaeria maculans | 44.68 | 4e-69 | 231 |
| LLPS-Cap-4642 | Cavia porcellus | 44.66 | 3e-68 | 222 |
| LLPS-Miv-1436 | Microbotryum violaceum | 44.3 | 1e-73 | 240 |
| LLPS-Blg-1279 | Blumeria graminis | 44.25 | 6e-70 | 231 |
| LLPS-Orn-0192 | Oreochromis niloticus | 44.18 | 5e-74 | 240 |
| LLPS-Otg-2216 | Otolemur garnettii | 44.09 | 3e-70 | 227 |
| LLPS-Scs-0276 | Sclerotinia sclerotiorum | 43.67 | 2e-74 | 244 |
| LLPS-Eqc-0698 | Equus caballus | 43.64 | 3e-54 | 189 |
| LLPS-Caf-0054 | Canis familiaris | 43.46 | 4e-70 | 230 |
| LLPS-Fus-1158 | Fusarium solani | 43.46 | 1e-70 | 232 |
| LLPS-Chs-2879 | Chlorocebus sabaeus | 43.45 | 6e-72 | 236 |
| LLPS-Paa-2349 | Papio anubis | 43.16 | 5e-70 | 231 |
| LLPS-Aon-4013 | Aotus nancymaae | 43.1 | 2e-72 | 237 |
| LLPS-Mup-4335 | Mustela putorius furo | 43.06 | 5e-71 | 233 |
| LLPS-Icp-2097 | Ictalurus punctatus | 43.04 | 9e-78 | 250 |
| LLPS-Bot-2714 | Bos taurus | 42.96 | 8e-71 | 231 |
| LLPS-Aim-2699 | Ailuropoda melanoleuca | 42.96 | 1e-67 | 223 |
| LLPS-Pyt-0305 | Pyrenophora teres | 42.86 | 7e-77 | 250 |
| LLPS-Pytr-0357 | Pyrenophora triticirepentis | 42.82 | 8e-73 | 240 |
| LLPS-Orc-1722 | Oryctolagus cuniculus | 42.81 | 1e-70 | 229 |
| LLPS-Mal-0988 | Mandrillus leucophaeus | 42.76 | 3e-71 | 232 |
| LLPS-Maf-1702 | Macaca fascicularis | 42.76 | 2e-70 | 232 |
| LLPS-Cea-0651 | Cercocebus atys | 42.76 | 2e-70 | 232 |
| LLPS-Asm-1623 | Astyanax mexicanus | 42.67 | 2e-75 | 244 |
| LLPS-Cis-1170 | Ciona savignyi | 42.57 | 3e-75 | 243 |
| LLPS-Poa-3795 | Pongo abelii | 42.52 | 2e-70 | 232 |
| LLPS-Xim-1129 | Xiphophorus maculatus | 42.49 | 8e-74 | 241 |
| LLPS-Scm-1270 | Scophthalmus maximus | 42.33 | 4e-72 | 236 |
| LLPS-Tar-2274 | Takifugu rubripes | 42.33 | 3e-74 | 241 |
| LLPS-Scj-0147 | Schizosaccharomyces japonicus | 42.23 | 4e-73 | 238 |
| LLPS-Gaga-3661 | Gallus gallus | 42.21 | 3e-71 | 233 |
| LLPS-Pug-0398 | Puccinia graminis | 42.21 | 1e-64 | 218 |
| LLPS-Ova-2552 | Ovis aries | 42.21 | 7e-71 | 231 |
| LLPS-Mam-4002 | Macaca mulatta | 42.19 | 1e-68 | 227 |
| LLPS-Man-0487 | Macaca nemestrina | 42.19 | 1e-68 | 226 |
| LLPS-Trr-0565 | Trichoderma reesei | 42.19 | 8e-76 | 243 |
| LLPS-Nol-4675 | Nomascus leucogenys | 42.18 | 6e-70 | 231 |
| LLPS-Hos-4580 | Homo sapiens | 42.18 | 1e-69 | 230 |
| LLPS-Gog-3822 | Gorilla gorilla | 42.18 | 7e-70 | 230 |
| LLPS-Pof-0636 | Poecilia formosa | 42.17 | 6e-74 | 241 |
| LLPS-Scf-0764 | Scleropages formosus | 42.16 | 2e-70 | 231 |
| LLPS-Dar-0251 | Danio rerio | 42.07 | 8e-77 | 248 |
| LLPS-Beb-0901 | Beauveria bassiana | 41.99 | 2e-76 | 247 |
| LLPS-Caj-3284 | Callithrix jacchus | 41.95 | 1e-71 | 236 |
| LLPS-Cii-1570 | Ciona intestinalis | 41.92 | 3e-65 | 217 |
| LLPS-Pat-3601 | Pan troglodytes | 41.84 | 6e-69 | 228 |
| LLPS-Xet-1699 | Xenopus tropicalis | 41.67 | 9e-69 | 227 |
| LLPS-Orl-0286 | Oryzias latipes | 41.61 | 2e-71 | 233 |
| LLPS-Pap-3213 | Pan paniscus | 41.59 | 5e-69 | 228 |
| LLPS-Gag-1218 | Gaeumannomyces graminis | 41.49 | 6e-68 | 229 |
| LLPS-Sus-4644 | Sus scrofa | 41.47 | 3e-71 | 232 |
| LLPS-Gaa-2441 | Gasterosteus aculeatus | 41.46 | 2e-72 | 236 |
| LLPS-Leo-2538 | Lepisosteus oculatus | 41.42 | 5e-73 | 238 |
| LLPS-Fec-3696 | Felis catus | 41.38 | 5e-69 | 227 |
| LLPS-Scc-0941 | Schizosaccharomyces cryophilus | 41.34 | 3e-62 | 208 |
| LLPS-Abg-0803 | Absidia glauca | 41.24 | 5e-67 | 222 |
| LLPS-Usm-1245 | Ustilago maydis | 41.18 | 1e-62 | 212 |
| LLPS-Lac-3338 | Latimeria chalumnae | 41.06 | 5e-62 | 207 |
| LLPS-Rhb-0173 | Rhinopithecus bieti | 40.91 | 2e-66 | 221 |
| LLPS-Ten-0311 | Tetraodon nigroviridis | 40.87 | 7e-46 | 169 |
| LLPS-Ran-2654 | Rattus norvegicus | 40.86 | 1e-67 | 224 |
| LLPS-Myl-0676 | Myotis lucifugus | 40.76 | 3e-66 | 221 |
| LLPS-Gas-1315 | Galdieria sulphuraria | 40.71 | 2e-61 | 210 |
| LLPS-Anc-2103 | Anolis carolinensis | 40.69 | 7e-44 | 165 |
| LLPS-Scp-0985 | Schizosaccharomyces pombe | 40.6 | 2e-77 | 248 |
| LLPS-Mum-2012 | Mus musculus | 40.53 | 2e-66 | 221 |
| LLPS-Pes-1434 | Pelodiscus sinensis | 40.42 | 3e-70 | 229 |
| LLPS-Meg-0424 | Meleagris gallopavo | 40.26 | 9e-44 | 164 |
| LLPS-Anp-0792 | Anas platyrhynchos | 40.26 | 1e-43 | 164 |
| LLPS-Fia-0351 | Ficedula albicollis | 39.83 | 2e-42 | 160 |
| LLPS-Drm-0750 | Drosophila melanogaster | 39.81 | 1e-66 | 221 |
| LLPS-Tag-3327 | Taeniopygia guttata | 39.74 | 2e-43 | 163 |
| LLPS-Cas-0352 | Carlito syrichta | 39.68 | 8e-63 | 212 |
| LLPS-Osl-0677 | Ostreococcus lucimarinus | 37.29 | 9e-57 | 194 |
| LLPS-Yal-0904 | Yarrowia lipolytica | 37.16 | 3e-42 | 155 |
| LLPS-Cym-0011 | Cyanidioschyzon merolae | 33.79 | 9e-51 | 178 |