• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Orc-1722
Sirt3

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: NAD-dependent protein deacetylase
Gene Name: Sirt3, SIRT3
Ensembl Gene: ENSOCUG00000025521.2
Ensembl Protein: ENSOCUP00000019306.2
Organism: Oryctolagus cuniculus
Taxa ID: 9986
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

NAD-dependent protein deacetylase.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MALWSQRVVA  ALRLWGPIGG  RRPVSLSARA  PSISGSRGRP  ERFSLQDVAE  LIRTGACQRV  60
61    VVMAGAGIST  PSGIPDFRTP  GSGLYSNLQK  YDIPYPEAIF  ELAFFFHNPK  PFFTLAKELY  120
121   PGNYRPNFTH  YFLRLLHDKR  LLLRLYTQNI  DGLERVAGIP  ASKLVEAHGT  FASASCTVCR  180
181   RCFPGEDFRG  DVMADRVPRC  PVCTGVVKPD  IVFFGEPLPQ  RFFLHVVDFP  MADLLLILGT  240
241   SLEVEPFASL  SEAVRSSVPR  LLINWDLVGP  LASRPRGRDV  AQLGDVVHGV  GKLVELLGWT  300
301   EEMHDLIQRE  TRKLDGRDT  319
Nucleotide CDS Sequence (FASTA)
1     ATGGCGCTGT  GGAGCCAGCG  GGTCGTGGCC  GCACTCAGGC  TGTGGGGCCC  GATAGGTGGA  60
61    AGAAGGCCTG  TCTCTCTGTC  GGCGAGGGCT  CCAAGCATCT  CTGGAAGCAG  AGGACGCCCT  120
121   GAGAGGTTTT  CACTGCAGGA  TGTAGCTGAG  CTGATTCGGA  CTGGAGCCTG  CCAGAGGGTG  180
181   GTGGTCATGG  CCGGAGCTGG  CATCAGCACT  CCCAGTGGGA  TCCCAGACTT  CAGGACTCCA  240
241   GGCAGCGGCC  TCTATAGCAA  CCTCCAGAAG  TATGACATCC  CTTACCCCGA  GGCCATTTTT  300
301   GAACTCGCTT  TTTTCTTTCA  CAACCCCAAG  CCCTTCTTCA  CATTGGCCAA  GGAGCTGTAC  360
361   CCTGGGAACT  ACAGGCCCAA  TTTCACTCAC  TACTTCCTCC  GACTGCTGCA  TGACAAGCGA  420
421   CTGCTCCTGC  GGCTGTACAC  ACAGAACATC  GACGGGCTGG  AGAGAGTGGC  AGGCATCCCT  480
481   GCCTCGAAGC  TGGTGGAAGC  CCATGGGACC  TTCGCCTCTG  CCAGCTGCAC  CGTCTGCCGG  540
541   AGATGCTTCC  CCGGGGAGGA  CTTCAGGGGT  GACGTGATGG  CAGACAGGGT  CCCCCGCTGC  600
601   CCCGTGTGCA  CTGGCGTCGT  GAAGCCCGAC  ATTGTGTTCT  TCGGGGAGCC  GCTGCCACAG  660
661   AGGTTCTTCC  TGCACGTGGT  CGACTTCCCC  ATGGCGGACC  TGCTGCTCAT  CCTGGGCACT  720
721   TCCCTGGAGG  TGGAGCCTTT  CGCCAGCTTG  TCTGAGGCCG  TGCGGAGCTC  CGTGCCCCGC  780
781   CTGCTCATCA  ACTGGGATTT  GGTGGGACCC  TTGGCTTCTC  GTCCTCGTGG  CAGGGACGTG  840
841   GCCCAGCTCG  GGGACGTGGT  TCACGGCGTG  GGAAAGCTGG  TGGAGCTTCT  GGGCTGGACA  900
901   GAAGAGATGC  ACGACCTTAT  CCAGCGGGAA  ACTAGAAAGC  TTGACGGCCG  GGACACATAG  960

▼ KEYWORD

ID
Family
Complete proteome
Hydrolase
Metal-binding
NAD
Reference proteome
Zinc

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Mitochondrial inner membrane
Cellular Component
Mitochondrial matrix
Cellular Component
Protein-containing complex
Molecular Function
NAD+ binding
Molecular Function
NAD-dependent histone deacetylase activity
Molecular Function
Sequence-specific DNA binding
Molecular Function
Zinc ion binding
Biological Process
Aerobic respiration
Biological Process
Negative regulation of peptidyl-lysine acetylation
Biological Process
Peptidyl-lysine deacetylation
Biological Process
Positive regulation of mitochondrial transcription

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ict-2858Ictidomys tridecemlineatus88.282e-151 433
LLPS-Fud-0215Fukomys damarensis87.914e-103 307
LLPS-Dio-4268Dipodomys ordii86.337e-149 426
LLPS-Paa-2349Papio anubis86.096e-174 495
LLPS-Otg-2216Otolemur garnettii86.031e-161 459
LLPS-Mal-0988Mandrillus leucophaeus86.08e-174 493
LLPS-Cea-0651Cercocebus atys85.761e-172 492
LLPS-Maf-1702Macaca fascicularis85.762e-172 492
LLPS-Gog-3822Gorilla gorilla85.431e-165 474
LLPS-Hos-4580Homo sapiens85.431e-165 474
LLPS-Nol-4675Nomascus leucogenys85.431e-171 490
LLPS-Poa-3795Pongo abelii85.432e-166 476
LLPS-Aon-4013Aotus nancymaae85.054e-170 486
LLPS-Pat-3601Pan troglodytes84.772e-164 471
LLPS-Chs-2879Chlorocebus sabaeus84.164e-163 468
LLPS-Cap-4642Cavia porcellus83.598e-146 418
LLPS-Caj-3284Callithrix jacchus82.552e-160 462
LLPS-Loa-4106Loxodonta africana82.147e-139 401
LLPS-Mod-1969Monodelphis domestica81.321e-151 441
LLPS-Mup-4335Mustela putorius furo80.332e-161 462
LLPS-Sah-3855Sarcophilus harrisii79.494e-152 437
LLPS-Ran-4412Rattus norvegicus79.315e-169 480
LLPS-Fec-3696Felis catus78.951e-156 450
LLPS-Caf-0054Canis familiaris78.951e-159 458
LLPS-Ora-1656Ornithorhynchus anatinus78.762e-53 177
LLPS-Mea-2908Mesocricetus auratus77.549e-166 472
LLPS-Eqc-0698Equus caballus77.526e-127 375
LLPS-Aim-2699Ailuropoda melanoleuca77.01e-154 444
LLPS-Pes-1434Pelodiscus sinensis76.084e-158 453
LLPS-Sus-4644Sus scrofa75.533e-164 468
LLPS-Man-1208Macaca nemestrina75.251e-141 412
LLPS-Gaga-3661Gallus gallus75.245e-155 445
LLPS-Ova-2552Ovis aries73.112e-156 448
LLPS-Bot-2714Bos taurus72.218e-158 452
LLPS-Mam-0121Macaca mulatta71.183e-144 418
LLPS-Pof-3186Poecilia formosa70.93e-122 360
LLPS-Tar-3010Takifugu rubripes70.26e-117 349
LLPS-Anc-2668Anolis carolinensis69.713e-148 427
LLPS-Leo-3952Lepisosteus oculatus69.577e-131 385
LLPS-Dar-4000Danio rerio69.235e-130 382
LLPS-Urm-1926Ursus maritimus68.842e-142 414
LLPS-Mum-1298Mus musculus68.831e-134 392
LLPS-Asm-0658Astyanax mexicanus68.631e-125 370
LLPS-Icp-0304Ictalurus punctatus68.613e-126 373
LLPS-Scf-0764Scleropages formosus68.382e-126 374
LLPS-Xim-3395Xiphophorus maculatus67.56e-124 366
LLPS-Orn-4040Oreochromis niloticus67.382e-127 373
LLPS-Orl-0286Oryzias latipes67.291e-116 347
LLPS-Xet-2012Xenopus tropicalis59.567e-108 323
LLPS-Gaa-3186Gasterosteus aculeatus58.434e-105 319
LLPS-Lac-3338Latimeria chalumnae57.544e-107 322
LLPS-Scm-1327Scophthalmus maximus57.31e-104 320
LLPS-Cii-1570Ciona intestinalis54.753e-101 309
LLPS-Trr-0565Trichoderma reesei54.515e-90 278
LLPS-Asfu-0515Aspergillus fumigatus51.942e-78 252
LLPS-Cis-1123Ciona savignyi51.898e-96 292
LLPS-Nef-0682Neosartorya fischeri51.762e-77 249
LLPS-Drm-0750Drosophila melanogaster51.388e-85 266
LLPS-Mel-0939Melampsora laricipopulina51.168e-79 248
LLPS-Cog-1211Colletotrichum gloeosporioides51.137e-85 270
LLPS-Pyt-0305Pyrenophora teres50.941e-80 259
LLPS-Pytr-0357Pyrenophora triticirepentis50.947e-81 259
LLPS-Asni-0922Aspergillus niger50.592e-76 245
LLPS-Lem-0743Leptosphaeria maculans50.573e-79 256
LLPS-Cogr-1166Colletotrichum graminicola50.575e-84 270
LLPS-Dos-0200Dothistroma septosporum50.574e-82 260
LLPS-Asc-0158Aspergillus clavatus50.385e-78 251
LLPS-Beb-0901Beauveria bassiana50.193e-82 261
LLPS-Asn-1007Aspergillus nidulans50.02e-80 255
LLPS-Trv-0640Trichoderma virens49.832e-87 274
LLPS-Nec-0584Neurospora crassa49.823e-78 250
LLPS-Abg-0803Absidia glauca49.487e-94 290
LLPS-Coo-0428Colletotrichum orbiculare49.448e-82 263
LLPS-Miv-1436Microbotryum violaceum49.343e-87 274
LLPS-Zyt-0654Zymoseptoria tritici49.121e-83 261
LLPS-Scp-0985Schizosaccharomyces pombe49.082e-81 257
LLPS-Rhb-0173Rhinopithecus bieti49.023e-83 263
LLPS-Pap-3213Pan paniscus48.992e-85 269
LLPS-Mao-0429Magnaporthe oryzae48.784e-84 268
LLPS-Ast-0065Aspergillus terreus48.757e-81 257
LLPS-Scj-0147Schizosaccharomyces japonicus48.686e-74 239
LLPS-Myl-0676Myotis lucifugus48.653e-85 268
LLPS-Gag-1218Gaeumannomyces graminis48.551e-78 255
LLPS-Gas-1315Galdieria sulphuraria48.479e-75 244
LLPS-Pug-0398Puccinia graminis48.467e-80 256
LLPS-Asf-0437Aspergillus flavus48.24e-80 255
LLPS-Aso-0178Aspergillus oryzae48.24e-80 255
LLPS-Fus-1158Fusarium solani48.062e-81 259
LLPS-Fuo-0778Fusarium oxysporum48.062e-82 263
LLPS-Scs-0276Sclerotinia sclerotiorum47.924e-75 244
LLPS-Blg-1279Blumeria graminis47.836e-82 260
LLPS-Cas-0352Carlito syrichta47.35e-79 252
LLPS-Fuv-0504Fusarium verticillioides46.257e-83 264
LLPS-Spr-0189Sporisorium reilianum45.859e-72 234
LLPS-Kop-0979Komagataella pastoris45.823e-67 221
LLPS-Osl-0677Ostreococcus lucimarinus45.363e-64 212
LLPS-Crn-0340Cryptococcus neoformans45.131e-74 242
LLPS-Usm-1245Ustilago maydis44.971e-78 253
LLPS-Asg-0022Ashbya gossypii44.323e-69 225
LLPS-Ved-0450Verticillium dahliae43.945e-60 201
LLPS-Scc-0941Schizosaccharomyces cryophilus43.182e-59 199
LLPS-Sac-0170Saccharomyces cerevisiae42.813e-64 213
LLPS-Yal-0904Yarrowia lipolytica41.862e-43 157
LLPS-Cym-0011Cyanidioschyzon merolae41.132e-50 176
LLPS-Meg-0424Meleagris gallopavo40.06e-53 189
LLPS-Anp-0792Anas platyrhynchos39.633e-52 187
LLPS-Tag-3327Taeniopygia guttata39.631e-52 187
LLPS-Fia-0351Ficedula albicollis39.262e-51 185
LLPS-Ten-0311Tetraodon nigroviridis39.053e-50 180