• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Pes-1434
SIRT3

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: NAD-dependent protein deacetylase
Gene Name: SIRT3
Ensembl Gene: ENSPSIG00000012618.1
Ensembl Protein: ENSPSIP00000014160.1
Organism: Pelodiscus sinensis
Taxa ID: 13735
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

NAD-dependent protein deacetylase.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSPSIT00000014226.1ENSPSIP00000014160.1
UniProtK7G1J9, K7G1J9_PELSI
GeneBankAGCU01010619

▼ SEQUENCE

Protein Sequence (FASTA)
1     KSLGCFSPSE  QLESFCHLLH  FLSAPRRIQG  ARPISLSAAA  TGIFGMGRGG  DDNGNQKLTL  60
61    QDVAELIQKK  ECHRMVVMAG  AGISTPSGIP  DFRSPGSGLY  SNLQQYDIPY  PEAIFELAYF  120
121   FHNPKPFFTL  AKELYPGNYR  PNYSHYFLRL  LHDKGLLLRL  YTQNIDGLER  IAGIPPDKLV  180
181   EAHGTFATAT  CTVCRRSYPG  EDFRGDVMAD  KIPHCPVCTG  LIKPDIVFFG  EQLPQRFFLH  240
241   VADFPMADVL  FIIGTSLEVQ  PFASLADAVR  SSIPRVLINR  DLVGPFAYQP  QYNDVALLGD  300
301   VVSGVEKFVE  LMAWKEEMQE  LIQRETEKKY  FGANR  335
Nucleotide CDS Sequence (FASTA)
1     AAAAGCTTGG  GTTGTTTTTC  TCCATCTGAG  CAGCTTGAGT  CTTTTTGTCA  CCTGCTGCAT  60
61    TTCCTTTCTG  CTCCTAGAAG  GATACAAGGG  GCCAGACCTA  TCTCTTTATC  CGCTGCTGCC  120
121   ACAGGCATCT  TTGGGATGGG  CAGAGGAGGA  GATGACAATG  GGAACCAGAA  GCTCACCCTG  180
181   CAGGACGTGG  CAGAATTAAT  TCAGAAGAAG  GAGTGTCACC  GAATGGTGGT  GATGGCTGGG  240
241   GCTGGGATCA  GTACTCCCAG  CGGCATCCCA  GATTTTAGGT  CTCCTGGGAG  TGGCCTGTAC  300
301   AGTAACCTTC  AGCAATATGA  CATTCCCTAT  CCAGAAGCCA  TCTTTGAACT  TGCCTATTTC  360
361   TTCCACAACC  CTAAGCCCTT  TTTCACTTTA  GCTAAGGAGT  TGTACCCTGG  CAATTACAGG  420
421   CCTAATTACT  CCCATTACTT  CTTGCGACTC  CTGCATGACA  AAGGGCTCCT  TCTGCGTCTG  480
481   TACACCCAGA  ATATTGACGG  GCTGGAAAGA  ATTGCTGGGA  TCCCTCCTGA  TAAGTTGGTA  540
541   GAAGCTCATG  GCACTTTCGC  CACTGCCACA  TGTACTGTCT  GTCGGAGATC  CTACCCAGGG  600
601   GAGGACTTCA  GAGGAGATGT  GATGGCAGAC  AAGATCCCCC  ACTGCCCAGT  CTGCACCGGA  660
661   CTCATCAAAC  CTGATATTGT  GTTCTTTGGA  GAGCAGCTCC  CTCAGCGGTT  CTTCCTACAC  720
721   GTGGCAGATT  TCCCCATGGC  AGATGTGCTC  TTTATCATTG  GAACCTCCCT  TGAGGTGCAG  780
781   CCCTTTGCCA  GTCTGGCAGA  TGCAGTCCGC  AGCTCTATTC  CTCGTGTGCT  GATCAATCGA  840
841   GACTTGGTGG  GACCATTTGC  ATACCAGCCA  CAGTACAATG  ATGTGGCCTT  GCTGGGAGAT  900
901   GTGGTCAGTG  GGGTGGAGAA  GTTTGTGGAG  CTGATGGCCT  GGAAGGAAGA  AATGCAGGAG  960
961   CTAATTCAAA  GGGAAACAGA  AAAGAAATAT  TTCGGTGCTA  ACAGGTAA  1008

▼ KEYWORD

ID
Family
Complete proteome
Hydrolase
Metal-binding
NAD
Reference proteome
Zinc

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Mitochondrial inner membrane
Cellular Component
Mitochondrial matrix
Cellular Component
Protein-containing complex
Molecular Function
NAD+ binding
Molecular Function
NAD-dependent histone deacetylase activity
Molecular Function
Sequence-specific DNA binding
Molecular Function
Zinc ion binding
Biological Process
Aerobic respiration
Biological Process
Negative regulation of peptidyl-lysine acetylation
Biological Process
Peptidyl-lysine deacetylation
Biological Process
Positive regulation of mitochondrial transcription

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Fud-0215Fukomys damarensis83.522e-98 296
LLPS-Gaga-3661Gallus gallus82.950.0 513
LLPS-Anc-2668Anolis carolinensis81.132e-176 499
LLPS-Ict-2858Ictidomys tridecemlineatus80.082e-139 402
LLPS-Gog-3822Gorilla gorilla79.041e-150 437
LLPS-Hos-4580Homo sapiens79.041e-150 437
LLPS-Mam-0121Macaca mulatta78.99e-129 379
LLPS-Dio-4268Dipodomys ordii78.491e-137 398
LLPS-Ora-1656Ornithorhynchus anatinus76.991e-54 181
LLPS-Chs-2879Chlorocebus sabaeus76.91e-149 434
LLPS-Loa-4106Loxodonta africana76.499e-132 383
LLPS-Orc-1722Oryctolagus cuniculus76.081e-158 454
LLPS-Otg-2216Otolemur garnettii76.031e-143 414
LLPS-Caj-3284Callithrix jacchus75.722e-145 424
LLPS-Cap-4642Cavia porcellus75.75e-133 387
LLPS-Sah-3855Sarcophilus harrisii75.691e-151 436
LLPS-Paa-2349Papio anubis75.598e-157 452
LLPS-Mal-0988Mandrillus leucophaeus75.592e-157 451
LLPS-Cea-0651Cercocebus atys75.592e-156 451
LLPS-Maf-1702Macaca fascicularis75.592e-156 451
LLPS-Nol-4675Nomascus leucogenys75.593e-156 451
LLPS-Mod-1969Monodelphis domestica75.355e-150 438
LLPS-Eqc-0698Equus caballus74.895e-116 348
LLPS-Mup-4335Mustela putorius furo74.582e-153 443
LLPS-Mea-2908Mesocricetus auratus74.584e-155 446
LLPS-Poa-3795Pongo abelii74.581e-149 434
LLPS-Pat-3601Pan troglodytes74.256e-149 432
LLPS-Aon-4013Aotus nancymaae73.917e-152 440
LLPS-Caf-0054Canis familiaris73.589e-149 431
LLPS-Ran-4412Rattus norvegicus72.914e-149 430
LLPS-Aim-2699Ailuropoda melanoleuca72.343e-140 408
LLPS-Fec-3696Felis catus71.572e-144 420
LLPS-Leo-3952Lepisosteus oculatus71.283e-137 402
LLPS-Tar-3010Takifugu rubripes70.452e-119 355
LLPS-Scf-0764Scleropages formosus70.112e-130 385
LLPS-Asm-0658Astyanax mexicanus70.119e-132 387
LLPS-Dar-4000Danio rerio69.423e-133 391
LLPS-Bot-2714Bos taurus69.413e-143 416
LLPS-Icp-0304Ictalurus punctatus69.061e-133 392
LLPS-Ova-2552Ovis aries68.421e-141 411
LLPS-Sus-4644Sus scrofa67.612e-146 423
LLPS-Xim-3395Xiphophorus maculatus66.796e-127 374
LLPS-Orn-4040Oreochromis niloticus66.793e-132 386
LLPS-Man-1208Macaca nemestrina66.561e-126 374
LLPS-Pof-3186Poecilia formosa65.827e-123 362
LLPS-Mum-1298Mus musculus63.371e-124 367
LLPS-Xet-2012Xenopus tropicalis63.02e-115 343
LLPS-Urm-1926Ursus maritimus62.928e-133 390
LLPS-Lac-3338Latimeria chalumnae59.491e-107 324
LLPS-Orl-0286Oryzias latipes57.493e-123 365
LLPS-Scm-1327Scophthalmus maximus56.933e-102 315
LLPS-Cii-1570Ciona intestinalis56.723e-98 301
LLPS-Gaa-3186Gasterosteus aculeatus56.187e-104 317
LLPS-Spr-0189Sporisorium reilianum53.014e-74 241
LLPS-Asfu-0515Aspergillus fumigatus52.762e-82 263
LLPS-Nef-0682Neosartorya fischeri51.971e-80 258
LLPS-Zyt-0654Zymoseptoria tritici51.725e-83 260
LLPS-Cis-1123Ciona savignyi51.551e-96 295
LLPS-Trr-0565Trichoderma reesei51.341e-82 260
LLPS-Asni-0922Aspergillus niger51.195e-79 253
LLPS-Pytr-0357Pyrenophora triticirepentis50.753e-81 261
LLPS-Pap-3213Pan paniscus50.699e-87 273
LLPS-Dos-0200Dothistroma septosporum50.578e-82 260
LLPS-Abg-0803Absidia glauca50.532e-93 289
LLPS-Drm-0750Drosophila melanogaster50.172e-83 264
LLPS-Myl-0676Myotis lucifugus49.832e-86 272
LLPS-Rhb-0173Rhinopithecus bieti49.837e-84 265
LLPS-Blg-1279Blumeria graminis49.815e-82 261
LLPS-Pyt-0305Pyrenophora teres49.639e-79 254
LLPS-Cogr-1166Colletotrichum graminicola49.621e-81 264
LLPS-Scp-0985Schizosaccharomyces pombe49.441e-81 258
LLPS-Asf-0437Aspergillus flavus49.434e-81 258
LLPS-Aso-0178Aspergillus oryzae49.434e-81 258
LLPS-Asn-1007Aspergillus nidulans49.431e-83 264
LLPS-Beb-0901Beauveria bassiana49.433e-80 256
LLPS-Cas-0352Carlito syrichta49.312e-82 262
LLPS-Asc-0158Aspergillus clavatus49.16e-80 256
LLPS-Nec-0584Neurospora crassa49.052e-77 248
LLPS-Fuv-0504Fusarium verticillioides48.884e-82 263
LLPS-Fuo-0778Fusarium oxysporum48.881e-81 262
LLPS-Cog-1211Colletotrichum gloeosporioides48.873e-82 263
LLPS-Mel-0939Melampsora laricipopulina48.845e-76 241
LLPS-Ast-0065Aspergillus terreus48.74e-82 261
LLPS-Trv-0640Trichoderma virens48.51e-81 259
LLPS-Lem-0743Leptosphaeria maculans48.132e-76 250
LLPS-Mao-1470Magnaporthe oryzae48.111e-73 243
LLPS-Gag-1218Gaeumannomyces graminis47.992e-77 253
LLPS-Miv-1436Microbotryum violaceum47.971e-84 268
LLPS-Kop-0979Komagataella pastoris47.456e-71 231
LLPS-Coo-0428Colletotrichum orbiculare47.181e-81 263
LLPS-Scj-0147Schizosaccharomyces japonicus47.085e-74 240
LLPS-Scs-0276Sclerotinia sclerotiorum46.077e-76 247
LLPS-Fus-1158Fusarium solani45.952e-80 257
LLPS-Pug-0398Puccinia graminis45.481e-76 248
LLPS-Usm-1245Ustilago maydis45.311e-76 248
LLPS-Gas-1315Galdieria sulphuraria44.669e-72 236
LLPS-Crn-0340Cryptococcus neoformans44.593e-76 246
LLPS-Scc-0941Schizosaccharomyces cryophilus44.038e-62 206
LLPS-Ten-0311Tetraodon nigroviridis43.62e-54 192
LLPS-Asg-0022Ashbya gossypii43.339e-66 217
LLPS-Yal-0904Yarrowia lipolytica43.312e-45 163
LLPS-Ved-0450Verticillium dahliae43.241e-57 196
LLPS-Meg-0424Meleagris gallopavo42.86e-55 195
LLPS-Tag-3327Taeniopygia guttata42.47e-55 194
LLPS-Anp-0792Anas platyrhynchos42.42e-54 193
LLPS-Osl-0677Ostreococcus lucimarinus42.241e-62 209
LLPS-Fia-0351Ficedula albicollis42.01e-53 192
LLPS-Sac-0170Saccharomyces cerevisiae40.421e-63 212
LLPS-Cym-0011Cyanidioschyzon merolae38.874e-50 176