LLPS-Yal-1325
BRE1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | E3 ubiquitin-protein ligase BRE1; RING-type E3 ubiquitin transferase BRE1 |
| Gene Name: | BRE1, YALI0B09559g |
| Ensembl Gene: | YALI0_B09559g |
| Ensembl Protein: | CAG82928 |
| Organism: | Yarrowia lipolytica |
| Taxa ID: | 284591 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus, Others | Predicted from orthologs | (View) |
▼ FUNCTION
| E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | CAG82928 | CAG82928 |
| UniProt | Q6CF78, BRE1_YARLI | |
| GeneBank | CR382128 | CAG82928.1 |
| RefSeq | XM_500684.1 | XP_500684.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MEDKRNAESA SLGASSGGDS KRARVAARPV SLEDVAEFQK EAIFRAMETY RREKETLEKQ 60 61 LETQGEKERE LEERVVRLGT WWDKVADRLA LVVGKYEFEK SKVKTEDVKK EEDTERDAGD 120 121 EDEVEVAPGP TGLATDLELE EKSASISSHF STLLDLIGDK ISKQDKTEVS RLSAGYTDMA 180 181 EQRHLLVRKI QDLEHEAQTM KNQYLAAAKK LDRYKSPTVK LIEGEDVEEK AEENGDQKTA 240 241 QMEEKKETED SPDTKDTGDT KALRETIQVQ EEQMKELDAK IAALEHEASL FNAKMADLSE 300 301 SDLLDHSGAF KAAKEQLSDK TGQILALEKS RDAISAEKMA LDENRQQYRS TIKREFEKRE 360 361 SELRSQLSRA ETDLVRIRTA RDEILADLSQ KKATEADKLK TIESLKELGE VYKLRIGTLE 420 421 SEVQRWRKEG NEGVNMSSNV EGKSLEELKK EVTVLTLTNQ SLMAEIPGME AAFVSAQKMA 480 481 ENKALDVADR ESRLTKLLAE KAKADEKYFA AMRHKDALGA ENAKLKAQMV KSSELVNQLQ 540 541 EVDAKTRAKI DVLEKTLSEY VSLHAKQQEA AKRLTSQVAE KTHMLNGAQK YLTTLKEEMK 600 601 QQGTKLSVGE HRARKLALDN AKLTKQIELS SFGGSSDEID ELRSIAMCSL CSKNWKDTAL 660 661 KVCGHVFCHQ CAQDRLDARL RKCPNCNKPF SQNDLLTVHL 700 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGAGGACA AACGCAACGC TGAAAGCGCA AGTTTGGGCG CTTCTTCCGG CGGCGACAGC 60 61 AAGCGGGCCC GTGTTGCGGC TCGCCCGGTG TCGCTGGAAG ACGTGGCCGA GTTCCAGAAA 120 121 GAGGCCATTT TCCGGGCCAT GGAAACCTAT CGACGTGAAA AAGAGACTCT GGAAAAGCAG 180 181 CTGGAGACGC AAGGCGAAAA GGAGCGGGAG CTGGAGGAGC GCGTCGTTCG CCTGGGCACG 240 241 TGGTGGGACA AGGTAGCCGA TCGGTTGGCC TTGGTGGTGG GCAAATATGA GTTTGAGAAA 300 301 TCAAAGGTCA AGACTGAAGA TGTGAAGAAG GAGGAAGACA CAGAGAGAGA CGCCGGTGAT 360 361 GAAGACGAAG TGGAGGTTGC ACCTGGACCT ACCGGATTGG CTACGGACCT GGAGCTGGAG 420 421 GAAAAAAGTG CCTCTATCTC GAGTCACTTC TCCACCCTTC TTGATCTCAT TGGGGACAAG 480 481 ATCTCCAAGC AGGACAAGAC GGAAGTGTCG CGTCTCAGTG CGGGATACAC GGATATGGCC 540 541 GAGCAGCGTC ATCTGCTGGT CCGGAAGATC CAAGATCTCG AACATGAGGC CCAGACCATG 600 601 AAAAACCAGT ACCTAGCAGC AGCCAAGAAG CTGGATAGGT ACAAGTCGCC CACCGTGAAG 660 661 TTGATTGAGG GCGAAGATGT CGAAGAGAAG GCGGAGGAGA ATGGCGACCA AAAGACTGCA 720 721 CAAATGGAGG AAAAGAAGGA AACTGAAGAT TCCCCAGATA CCAAAGATAC CGGAGATACT 780 781 AAGGCCCTGA GAGAAACCAT ACAAGTCCAG GAGGAACAAA TGAAAGAACT GGACGCGAAA 840 841 ATTGCTGCTC TGGAGCACGA GGCTAGTCTG TTCAATGCGA AAATGGCGGA TCTGTCCGAA 900 901 TCCGACCTCC TGGATCACTC TGGAGCATTT AAGGCTGCAA AGGAGCAGCT GAGCGATAAA 960 961 ACAGGGCAGA TTTTGGCGCT GGAAAAATCC CGTGACGCCA TTTCAGCTGA AAAAATGGCC 1020 1021 CTCGACGAAA ACAGACAACA ATACCGGTCG ACTATCAAGC GGGAGTTTGA AAAACGCGAG 1080 1081 TCTGAGCTCC GTTCGCAGCT GTCACGGGCC GAAACCGATC TTGTGCGAAT CAGAACAGCC 1140 1141 AGAGACGAGA TTCTGGCAGA CTTGAGCCAG AAAAAGGCCA CTGAAGCGGA CAAACTTAAG 1200 1201 ACGATTGAGT CACTGAAAGA ATTAGGCGAG GTGTACAAGC TGCGAATTGG CACTTTGGAG 1260 1261 TCTGAGGTTC AGCGGTGGAG AAAAGAGGGA AACGAAGGAG TTAACATGTC CAGCAATGTC 1320 1321 GAGGGAAAGT CGCTGGAAGA GCTCAAGAAG GAGGTGACGG TCCTGACGCT GACTAATCAG 1380 1381 AGTCTAATGG CCGAGATCCC CGGAATGGAG GCTGCGTTTG TGTCTGCGCA GAAGATGGCC 1440 1441 GAAAACAAGG CTTTGGACGT GGCAGACCGT GAAAGCAGGT TAACTAAGTT GCTTGCAGAG 1500 1501 AAGGCCAAGG CCGATGAAAA GTACTTTGCG GCCATGCGAC ACAAGGACGC GCTGGGTGCC 1560 1561 GAGAACGCCA AGCTCAAGGC GCAGATGGTC AAGTCTAGTG AGCTAGTCAA CCAGCTCCAG 1620 1621 GAGGTGGATG CCAAGACGCG CGCCAAGATT GACGTGCTCG AGAAGACGTT ATCGGAGTAC 1680 1681 GTTTCTCTTC ATGCAAAGCA ACAGGAAGCC GCCAAGCGTC TGACTAGCCA GGTGGCCGAA 1740 1741 AAAACGCACA TGTTGAACGG CGCTCAAAAG TACCTGACGA CGCTCAAGGA GGAAATGAAG 1800 1801 CAGCAGGGCA CAAAGCTGTC GGTTGGAGAG CATAGAGCTC GAAAACTGGC TCTGGATAAT 1860 1861 GCCAAACTGA CCAAGCAGAT CGAGTTGTCT TCTTTTGGAG GCTCTTCTGA TGAAATTGAC 1920 1921 GAGCTGCGGT CTATTGCAAT GTGTTCCCTG TGTTCGAAAA ACTGGAAAGA CACTGCCCTC 1980 1981 AAGGTCTGTG GACACGTCTT TTGTCACCAG TGTGCACAGG ACCGGCTGGA TGCGCGGTTG 2040 2041 CGAAAGTGTC CCAACTGCAA CAAGCCCTTT TCCCAAAATG ATCTGTTGAC CGTTCATTTG 2100 2101 TAG 2103 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Nucleus | |
Molecular Function | Metal ion binding | |
Molecular Function | Nucleic acid binding | |
Molecular Function | Ubiquitin-protein transferase activity | |
Biological Process | Histone monoubiquitination |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Orm-1297 | Oryza meridionalis | 42.62 | 3e-10 | 68.2 |
| LLPS-Sei-0887 | Setaria italica | 42.19 | 7e-11 | 69.7 |
| LLPS-Prp-1109 | Prunus persica | 41.27 | 1e-10 | 68.9 |
| LLPS-Orgl-0930 | Oryza glumaepatula | 40.62 | 2e-10 | 68.6 |
| LLPS-Tut-0582 | Tursiops truncatus | 40.62 | 1e-10 | 69.3 |
| LLPS-Dio-0296 | Dipodomys ordii | 40.62 | 2e-10 | 68.6 |
| LLPS-Bot-3882 | Bos taurus | 40.62 | 1e-10 | 69.7 |
| LLPS-Ran-2707 | Rattus norvegicus | 40.62 | 2e-10 | 68.9 |
| LLPS-Aim-3289 | Ailuropoda melanoleuca | 40.62 | 1e-10 | 69.7 |
| LLPS-Mup-2984 | Mustela putorius furo | 40.62 | 1e-10 | 69.3 |
| LLPS-Ova-1719 | Ovis aries | 40.62 | 1e-10 | 69.3 |
| LLPS-Myl-0400 | Myotis lucifugus | 40.62 | 1e-10 | 69.3 |
| LLPS-Mea-0841 | Mesocricetus auratus | 40.62 | 2e-10 | 68.9 |
| LLPS-Mum-2768 | Mus musculus | 40.62 | 2e-10 | 68.6 |
| LLPS-Orb-1201 | Oryza barthii | 40.62 | 3e-10 | 67.8 |
| LLPS-Sah-1844 | Sarcophilus harrisii | 40.62 | 1e-10 | 69.3 |
| LLPS-Ori-0225 | Oryza indica | 40.62 | 3e-10 | 67.8 |
| LLPS-Sus-0007 | Sus scrofa | 40.62 | 1e-10 | 69.3 |
| LLPS-Hea-1284 | Helianthus annuus | 40.62 | 1e-09 | 65.9 |
| LLPS-Php-2421 | Physcomitrella patens | 40.62 | 2e-11 | 71.6 |
| LLPS-Orni-2174 | Oryza nivara | 40.62 | 3e-10 | 67.8 |
| LLPS-Orr-0675 | Oryza rufipogon | 40.62 | 3e-10 | 67.8 |
| LLPS-Caf-1654 | Canis familiaris | 40.62 | 1e-10 | 69.3 |
| LLPS-Eqc-0582 | Equus caballus | 40.62 | 1e-10 | 68.9 |
| LLPS-Ict-0523 | Ictidomys tridecemlineatus | 40.62 | 1e-10 | 69.3 |
| LLPS-Org-0196 | Oryza glaberrima | 40.62 | 3e-10 | 67.8 |
| LLPS-Fec-3050 | Felis catus | 40.62 | 1e-10 | 69.3 |
| LLPS-Mod-2018 | Monodelphis domestica | 40.62 | 1e-10 | 69.3 |
| LLPS-Ors-0309 | Oryza sativa | 40.62 | 3e-10 | 67.8 |
| LLPS-Loa-2046 | Loxodonta africana | 40.62 | 1e-10 | 69.3 |
| LLPS-Orc-2153 | Oryctolagus cuniculus | 40.62 | 1e-10 | 69.3 |
| LLPS-Gas-1343 | Galdieria sulphuraria | 40.32 | 9e-07 | 56.6 |
| LLPS-Chc-1017 | Chondrus crispus | 40.32 | 6e-09 | 63.5 |
| LLPS-Tru-1939 | Triticum urartu | 40.0 | 1e-11 | 72.4 |
| LLPS-Via-2023 | Vigna angularis | 39.68 | 6e-09 | 63.9 |
| LLPS-Met-2277 | Medicago truncatula | 39.68 | 8e-09 | 63.2 |
| LLPS-Vir-0153 | Vigna radiata | 39.68 | 1e-08 | 63.2 |
| LLPS-Mua-1950 | Musa acuminata | 39.68 | 2e-10 | 68.2 |
| LLPS-Pot-1369 | Populus trichocarpa | 39.68 | 1e-09 | 65.9 |
| LLPS-Phv-1766 | Phaseolus vulgaris | 39.68 | 2e-09 | 65.1 |
| LLPS-Tar-2245 | Takifugu rubripes | 39.06 | 6e-10 | 67.0 |
| LLPS-Lep-0958 | Leersia perrieri | 39.06 | 1e-09 | 66.2 |
| LLPS-Scf-0723 | Scleropages formosus | 39.06 | 4e-10 | 67.4 |
| LLPS-Mal-1230 | Mandrillus leucophaeus | 39.06 | 2e-10 | 68.6 |
| LLPS-Paa-3273 | Papio anubis | 39.06 | 1e-10 | 68.9 |
| LLPS-Glm-0741 | Glycine max | 39.06 | 7e-10 | 66.6 |
| LLPS-Maf-0870 | Macaca fascicularis | 39.06 | 2e-10 | 68.6 |
| LLPS-Chs-3446 | Chlorocebus sabaeus | 39.06 | 1e-10 | 68.9 |
| LLPS-Ora-1955 | Ornithorhynchus anatinus | 39.06 | 1e-10 | 69.3 |
| LLPS-Aon-0755 | Aotus nancymaae | 39.06 | 2e-10 | 68.6 |
| LLPS-Cis-0171 | Ciona savignyi | 39.06 | 3e-09 | 64.7 |
| LLPS-Cea-0535 | Cercocebus atys | 39.06 | 1e-10 | 68.9 |
| LLPS-Leo-2551 | Lepisosteus oculatus | 39.06 | 6e-10 | 65.5 |
| LLPS-Gog-2925 | Gorilla gorilla | 39.06 | 2e-10 | 68.6 |
| LLPS-Fud-0608 | Fukomys damarensis | 39.06 | 2e-10 | 68.6 |
| LLPS-Asm-3596 | Astyanax mexicanus | 39.06 | 1e-10 | 68.9 |
| LLPS-Icp-3642 | Ictalurus punctatus | 39.06 | 1e-10 | 69.3 |
| LLPS-Caj-2240 | Callithrix jacchus | 39.06 | 2e-10 | 68.6 |
| LLPS-Poa-4021 | Pongo abelii | 39.06 | 1e-10 | 68.9 |
| LLPS-Ten-3424 | Tetraodon nigroviridis | 39.06 | 5e-10 | 67.4 |
| LLPS-Cap-3961 | Cavia porcellus | 39.06 | 2e-10 | 68.2 |
| LLPS-Mam-1600 | Macaca mulatta | 39.06 | 2e-10 | 68.6 |
| LLPS-Gaga-2752 | Gallus gallus | 39.06 | 3e-10 | 68.2 |
| LLPS-Cas-1548 | Carlito syrichta | 39.06 | 1e-10 | 69.3 |
| LLPS-Nol-1086 | Nomascus leucogenys | 39.06 | 1e-10 | 68.9 |
| LLPS-Tag-2933 | Taeniopygia guttata | 39.06 | 1e-10 | 68.9 |
| LLPS-Pat-1147 | Pan troglodytes | 39.06 | 2e-10 | 68.6 |
| LLPS-Pap-1292 | Pan paniscus | 39.06 | 1e-10 | 68.9 |
| LLPS-Urm-2353 | Ursus maritimus | 39.06 | 1e-10 | 68.9 |
| LLPS-Hos-0347 | Homo sapiens | 39.06 | 2e-10 | 68.6 |
| LLPS-Meg-1119 | Meleagris gallopavo | 39.06 | 6e-10 | 67.0 |
| LLPS-Dar-0323 | Danio rerio | 39.06 | 1e-10 | 69.3 |
| LLPS-Man-2092 | Macaca nemestrina | 39.06 | 1e-10 | 68.9 |
| LLPS-Anp-3271 | Anas platyrhynchos | 39.06 | 1e-10 | 69.3 |
| LLPS-Otg-0346 | Otolemur garnettii | 39.06 | 1e-10 | 69.3 |
| LLPS-Orbr-0500 | Oryza brachyantha | 39.06 | 5e-10 | 67.4 |
| LLPS-Pes-2491 | Pelodiscus sinensis | 39.06 | 1e-10 | 68.9 |
| LLPS-Fia-1761 | Ficedula albicollis | 39.06 | 1e-10 | 69.3 |
| LLPS-Rhb-1148 | Rhinopithecus bieti | 39.06 | 2e-10 | 68.6 |
| LLPS-Tra-2789 | Triticum aestivum | 38.75 | 8e-12 | 73.2 |
| LLPS-Brd-0820 | Brachypodium distachyon | 38.46 | 4e-11 | 70.9 |
| LLPS-Coc-2126 | Corchorus capsularis | 38.46 | 2e-09 | 65.5 |
| LLPS-Sob-0639 | Sorghum bicolor | 38.46 | 8e-11 | 69.7 |
| LLPS-Sol-1259 | Solanum lycopersicum | 38.33 | 8e-08 | 60.1 |
| LLPS-Nia-2378 | Nicotiana attenuata | 38.33 | 1e-07 | 58.9 |
| LLPS-Viv-1608 | Vitis vinifera | 38.1 | 6e-09 | 63.5 |
| LLPS-Mae-2043 | Manihot esculenta | 37.97 | 2e-09 | 65.1 |
| LLPS-Cus-1706 | Cucumis sativus | 37.5 | 2e-11 | 72.0 |
| LLPS-Sem-1414 | Selaginella moellendorffii | 37.5 | 4e-09 | 64.3 |
| LLPS-Dac-1596 | Daucus carota | 37.5 | 1e-08 | 62.4 |
| LLPS-Gor-1343 | Gossypium raimondii | 37.35 | 1e-09 | 66.2 |
| LLPS-Thc-2344 | Theobroma cacao | 36.51 | 6e-08 | 60.5 |
| LLPS-Lac-2713 | Latimeria chalumnae | 36.14 | 1e-10 | 69.3 |
| LLPS-Chr-1151 | Chlamydomonas reinhardtii | 35.94 | 3e-08 | 61.6 |
| LLPS-Xim-1015 | Xiphophorus maculatus | 34.94 | 3e-10 | 67.8 |
| LLPS-Gaa-1578 | Gasterosteus aculeatus | 34.94 | 6e-10 | 67.0 |
| LLPS-Orl-0438 | Oryzias latipes | 34.94 | 3e-10 | 68.2 |
| LLPS-Xet-1092 | Xenopus tropicalis | 34.94 | 3e-10 | 68.2 |
| LLPS-Anc-1806 | Anolis carolinensis | 34.94 | 2e-10 | 68.6 |
| LLPS-Scm-0403 | Scophthalmus maximus | 34.94 | 4e-10 | 67.4 |
| LLPS-Orn-2735 | Oreochromis niloticus | 34.94 | 4e-10 | 67.4 |
| LLPS-Hov-0832 | Hordeum vulgare | 34.92 | 1e-07 | 59.3 |
| LLPS-Zem-0054 | Zea mays | 34.92 | 4e-08 | 61.2 |
| LLPS-Asg-1357 | Ashbya gossypii | 34.37 | 1e-44 | 173 |
| LLPS-Brn-1266 | Brassica napus | 33.33 | 5e-08 | 60.8 |
| LLPS-Cae-1645 | Caenorhabditis elegans | 33.33 | 1e-06 | 56.2 |
| LLPS-Bro-2701 | Brassica oleracea | 33.33 | 5e-08 | 60.5 |
| LLPS-Brr-0467 | Brassica rapa | 33.33 | 5e-08 | 60.8 |
| LLPS-Drm-1769 | Drosophila melanogaster | 33.1 | 1e-09 | 65.9 |
| LLPS-Cym-0038 | Cyanidioschyzon merolae | 32.26 | 4e-06 | 54.3 |
| LLPS-Pof-0427 | Poecilia formosa | 32.0 | 5e-12 | 73.9 |
| LLPS-Cogr-1156 | Colletotrichum graminicola | 31.85 | 3e-52 | 197 |
| LLPS-Crn-0545 | Cryptococcus neoformans | 31.54 | 2e-19 | 97.4 |
| LLPS-Arl-2007 | Arabidopsis lyrata | 31.43 | 6e-09 | 63.5 |
| LLPS-Art-2690 | Arabidopsis thaliana | 31.43 | 9e-09 | 63.2 |
| LLPS-Asni-1500 | Aspergillus niger | 31.13 | 7e-70 | 248 |
| LLPS-Kop-1360 | Komagataella pastoris | 29.93 | 3e-45 | 176 |
| LLPS-Nec-0296 | Neurospora crassa | 29.24 | 6e-57 | 211 |
| LLPS-Phn-0634 | Phaeosphaeria nodorum | 29.14 | 4e-56 | 209 |
| LLPS-Miv-1272 | Microbotryum violaceum | 29.1 | 3e-13 | 77.8 |
| LLPS-Cii-2064 | Ciona intestinalis | 29.0 | 3e-12 | 74.3 |
| LLPS-Pytr-1485 | Pyrenophora triticirepentis | 28.88 | 8e-55 | 205 |
| LLPS-Tum-0990 | Tuber melanosporum | 28.69 | 2e-67 | 241 |
| LLPS-Dos-1459 | Dothistroma septosporum | 28.61 | 7e-48 | 184 |
| LLPS-Trr-1343 | Trichoderma reesei | 28.25 | 2e-55 | 206 |
| LLPS-Lem-0664 | Leptosphaeria maculans | 28.2 | 2e-52 | 198 |
| LLPS-Sac-1021 | Saccharomyces cerevisiae | 28.17 | 4e-43 | 169 |
| LLPS-Pug-0737 | Puccinia graminis | 27.82 | 7e-13 | 76.3 |
| LLPS-Mel-1429 | Melampsora laricipopulina | 26.45 | 2e-08 | 61.6 |
| LLPS-Abg-1598 | Absidia glauca | 25.13 | 4e-10 | 67.4 |
| LLPS-Usm-0649 | Ustilago maydis | 24.11 | 3e-19 | 96.7 |
| LLPS-Spr-1179 | Sporisorium reilianum | 23.78 | 7e-20 | 98.6 |