LLPS-Yal-0218
ATG7
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Ubiquitin-like modifier-activating enzyme ATG7; ATG12-activating enzyme E1 ATG7; Autophagy-related protein 7 |
| Gene Name: | ATG7, YALI0C20119g |
| Ensembl Gene: | YALI0_C20119g |
| Ensembl Protein: | CAG82359 |
| Organism: | Yarrowia lipolytica |
| Taxa ID: | 284591 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Plays a role in the regulation of filamentous growth and chronological longevity (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | CAG82359 | CAG82359 |
| UniProt | Q6CBC3, ATG7_YARLI | |
| GeneBank | CR382129 | CAG82359.1 |
| RefSeq | XM_502039.1 | XP_502039.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSFTPFSSFL EASFFQTLAA KKLNEYKLDD SPKRVSAEYT WQQGRLVFDS DSFSDRDSHC 60 61 KGVVECPGTL LNYNTIEEFK GADKKALLAE WGDKMLSGAI MNGSIFRNPE ILNSFLLITF 120 121 CDLKKYIFVY WMGVPCLNTK WDLQEVADEG NYTNLSTRIP ALGESFVVID PDDNVTPFSE 180 181 LEYVERSEDP TIAFLSPTSP ENTPWTVRNI CLMLHILGFK SATMILVGRE KNRFLEWKRG 240 241 DGELGAWTGW EKNSAGKLLP KQTNLGPLLN PLQLASQAVD LNLKLMKWRI APELDLDTIK 300 301 HTRCLLLGAG TLGSYVSRSL LAWGVEQVTF VDNGTVSFSN PVRQPLYKYV DCLDGGKPKA 360 361 ETAAEALKEI YPAVKTSGIT LEVPMIGHST TSSSEKRVHQ QYDELVSLIK SHDAVFLLMD 420 421 SRESRWLPTV ICAALKKKCI TAAIGFDSFV VMRHGVEGVN DLGCYFCNDV VAPTDSMNDR 480 481 TLDQQCTVTR PGIAPIVSGY GVEILQAMCQ DEPSAPHQLR GFLHNFSTVK ITGQRFKCCS 540 541 ACSPVIVQEW KDKTWGFVKK ALNERGFVEE LCGLAELQRG VDELDFGEGE GSEEEWEM 598 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAGTTTCA CGCCGTTTTC GTCGTTTTTG GAAGCGTCTT TCTTCCAGAC TCTGGCTGCC 60 61 AAAAAACTCA ATGAGTACAA ACTCGACGAT TCGCCTAAGA GGGTCTCCGC AGAATACACA 120 121 TGGCAACAAG GTCGGCTCGT TTTCGACAGC GACTCGTTTT CGGACCGAGA TTCGCACTGC 180 181 AAGGGCGTTG TTGAGTGTCC CGGAACTCTA CTCAACTACA ACACGATAGA GGAGTTCAAA 240 241 GGAGCAGACA AAAAGGCGCT ACTGGCGGAA TGGGGTGACA AGATGTTGTC GGGTGCAATT 300 301 ATGAATGGAT CTATTTTCCG GAATCCCGAG ATTCTCAACT CTTTTCTTCT TATCACCTTC 360 361 TGCGATCTTA AAAAGTACAT CTTCGTCTAC TGGATGGGAG TGCCCTGCCT GAACACAAAG 420 421 TGGGACCTGC AGGAGGTGGC AGATGAGGGA AACTACACGA ATCTTAGTAC GCGCATCCCG 480 481 GCTCTCGGAG AATCGTTTGT TGTTATTGAT CCCGATGACA ACGTCACTCC CTTCAGTGAG 540 541 TTGGAGTATG TGGAGCGATC CGAGGACCCT ACGATTGCAT TTCTATCACC GACATCTCCT 600 601 GAGAACACAC CCTGGACCGT CCGAAACATT TGTCTAATGC TGCATATCCT AGGGTTCAAG 660 661 TCTGCGACCA TGATCTTAGT TGGGCGTGAG AAAAACCGGT TTCTCGAGTG GAAGCGGGGA 720 721 GACGGGGAGC TTGGTGCATG GACTGGCTGG GAAAAAAACA GTGCGGGAAA GCTGTTACCT 780 781 AAGCAGACCA ACTTGGGGCC TCTGTTGAAC CCTCTACAGC TGGCCTCTCA AGCTGTGGAT 840 841 CTCAATCTGA AGCTGATGAA GTGGAGAATT GCGCCTGAGT TGGATCTGGA TACCATCAAA 900 901 CACACCAGGT GCCTCCTTCT GGGTGCCGGA ACGCTCGGAA GCTATGTCTC CCGCTCTCTG 960 961 TTAGCTTGGG GAGTTGAACA GGTCACGTTT GTGGACAATG GAACTGTCTC ATTTAGCAAT 1020 1021 CCTGTTCGCC AGCCTCTATA CAAGTATGTA GATTGTTTGG ATGGAGGCAA ACCCAAGGCT 1080 1081 GAGACTGCTG CTGAAGCTCT CAAGGAGATA TATCCTGCAG TCAAGACATC GGGAATAACT 1140 1141 CTTGAGGTGC CTATGATTGG TCATAGCACC ACTTCCAGCA GTGAGAAGCG AGTCCACCAG 1200 1201 CAGTATGACG AGCTGGTGTC TCTCATTAAG TCTCATGATG CTGTGTTTCT GCTCATGGAC 1260 1261 TCACGAGAGT CGAGATGGTT GCCTACTGTT ATATGTGCAG CTCTCAAGAA GAAGTGTATC 1320 1321 ACGGCTGCCA TTGGTTTTGA CTCGTTTGTG GTGATGCGGC ATGGAGTGGA GGGAGTGAAT 1380 1381 GATCTGGGCT GTTACTTTTG TAATGATGTT GTTGCTCCTA CAGATTCTAT GAACGACAGA 1440 1441 ACGTTGGACC AACAATGTAC AGTGACCCGG CCTGGAATTG CTCCTATTGT TTCTGGATAC 1500 1501 GGAGTAGAGA TTTTGCAGGC CATGTGTCAA GACGAGCCCT CAGCCCCTCA TCAGCTGCGA 1560 1561 GGCTTTCTGC ACAACTTTTC TACTGTCAAG ATCACTGGTC AACGGTTCAA GTGTTGTTCC 1620 1621 GCTTGCAGTC CAGTCATTGT CCAGGAGTGG AAGGACAAGA CGTGGGGGTT TGTCAAGAAG 1680 1681 GCTCTTAATG AGAGAGGGTT TGTGGAGGAG CTGTGTGGTT TAGCTGAGCT GCAGAGAGGT 1740 1741 GTGGATGAGC TGGACTTTGG AGAGGGCGAA GGTAGCGAGG AGGAGTGGGA AATGTAG 1797 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Phagophore assembly site | |
Molecular Function | Atg12 activating enzyme activity | |
Molecular Function | Atg8 activating enzyme activity | |
Biological Process | Autophagosome assembly | |
Biological Process | Autophagy of mitochondrion | |
Biological Process | C-terminal protein lipidation | |
Biological Process | Cellular response to nitrogen starvation | |
Biological Process | Late nucleophagy | |
Biological Process | Piecemeal microautophagy of the nucleus | |
Biological Process | Protein modification by small protein conjugation | |
Biological Process | Protein transport |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Asfu-1014 | Aspergillus fumigatus | 50.23 | 1e-131 | 409 |
| LLPS-Asc-1565 | Aspergillus clavatus | 49.42 | 6e-132 | 409 |
| LLPS-Asf-0936 | Aspergillus flavus | 49.08 | 9e-135 | 413 |
| LLPS-Aso-1417 | Aspergillus oryzae | 48.96 | 6e-133 | 412 |
| LLPS-Beb-1608 | Beauveria bassiana | 48.41 | 1e-125 | 393 |
| LLPS-Asni-1150 | Aspergillus niger | 47.75 | 6e-60 | 206 |
| LLPS-Nef-1593 | Neosartorya fischeri | 47.05 | 9e-127 | 397 |
| LLPS-Fuv-0990 | Fusarium verticillioides | 47.03 | 1e-53 | 202 |
| LLPS-Chr-1421 | Chlamydomonas reinhardtii | 46.98 | 8e-105 | 343 |
| LLPS-Dos-0354 | Dothistroma septosporum | 45.83 | 1e-119 | 381 |
| LLPS-Kop-1012 | Komagataella pastoris | 43.29 | 2e-164 | 492 |
| LLPS-Tum-1059 | Tuber melanosporum | 42.52 | 6e-162 | 485 |
| LLPS-Fuo-1037 | Fusarium oxysporum | 42.1 | 3e-162 | 487 |
| LLPS-Cog-1156 | Colletotrichum gloeosporioides | 42.08 | 7e-163 | 489 |
| LLPS-Cogr-1399 | Colletotrichum graminicola | 42.05 | 3e-157 | 475 |
| LLPS-Trr-0102 | Trichoderma reesei | 41.73 | 2e-147 | 449 |
| LLPS-Asn-1608 | Aspergillus nidulans | 41.72 | 1e-151 | 459 |
| LLPS-Scs-1006 | Sclerotinia sclerotiorum | 41.69 | 7e-162 | 486 |
| LLPS-Asg-1065 | Ashbya gossypii | 41.61 | 2e-133 | 411 |
| LLPS-Tru-1436 | Triticum urartu | 41.54 | 3e-70 | 250 |
| LLPS-Sei-2122 | Setaria italica | 41.3 | 5e-70 | 249 |
| LLPS-Hov-0586 | Hordeum vulgare | 41.23 | 1e-69 | 248 |
| LLPS-Tra-2469 | Triticum aestivum | 41.23 | 9e-70 | 248 |
| LLPS-Ved-1343 | Verticillium dahliae | 41.22 | 4e-153 | 464 |
| LLPS-Org-1822 | Oryza glaberrima | 41.16 | 7e-68 | 243 |
| LLPS-Orm-0737 | Oryza meridionalis | 41.16 | 1e-67 | 243 |
| LLPS-Brd-2162 | Brachypodium distachyon | 41.07 | 1e-68 | 245 |
| LLPS-Trv-1178 | Trichoderma virens | 41.04 | 3e-144 | 441 |
| LLPS-Nec-0612 | Neurospora crassa | 40.86 | 7e-154 | 466 |
| LLPS-Ors-2148 | Oryza sativa | 40.85 | 4e-67 | 241 |
| LLPS-Orp-1234 | Oryza punctata | 40.85 | 1e-67 | 242 |
| LLPS-Orr-2250 | Oryza rufipogon | 40.85 | 1e-67 | 242 |
| LLPS-Orni-2245 | Oryza nivara | 40.85 | 1e-67 | 242 |
| LLPS-Ori-1296 | Oryza indica | 40.85 | 1e-67 | 242 |
| LLPS-Fus-1078 | Fusarium solani | 40.71 | 1e-155 | 471 |
| LLPS-Mao-0506 | Magnaporthe oryzae | 40.47 | 1e-150 | 458 |
| LLPS-Map-0669 | Magnaporthe poae | 40.42 | 6e-146 | 446 |
| LLPS-Sob-0905 | Sorghum bicolor | 40.41 | 1e-67 | 242 |
| LLPS-Gag-1089 | Gaeumannomyces graminis | 40.23 | 9e-142 | 435 |
| LLPS-Orbr-1525 | Oryza brachyantha | 40.12 | 4e-67 | 241 |
| LLPS-Orb-2353 | Oryza barthii | 40.12 | 2e-65 | 236 |
| LLPS-Orgl-2156 | Oryza glumaepatula | 40.12 | 5e-65 | 235 |
| LLPS-Phn-1045 | Phaeosphaeria nodorum | 40.1 | 5e-123 | 383 |
| LLPS-Mae-2356 | Manihot esculenta | 40.04 | 1e-101 | 328 |
| LLPS-Abg-0665 | Absidia glauca | 40.0 | 2e-122 | 381 |
| LLPS-Sac-1552 | Saccharomyces cerevisiae | 39.81 | 7e-144 | 438 |
| LLPS-Cii-1243 | Ciona intestinalis | 39.76 | 8e-133 | 411 |
| LLPS-Coo-0675 | Colletotrichum orbiculare | 39.7 | 1e-148 | 452 |
| LLPS-Zem-1672 | Zea mays | 39.66 | 1e-68 | 245 |
| LLPS-Aim-2089 | Ailuropoda melanoleuca | 39.44 | 6e-129 | 399 |
| LLPS-Cas-1960 | Carlito syrichta | 39.22 | 1e-129 | 402 |
| LLPS-Mea-3802 | Mesocricetus auratus | 39.09 | 2e-137 | 425 |
| LLPS-Scp-0696 | Schizosaccharomyces pombe | 39.02 | 3e-134 | 414 |
| LLPS-Lem-0277 | Leptosphaeria maculans | 39.0 | 1e-102 | 328 |
| LLPS-Otg-3525 | Otolemur garnettii | 38.91 | 6e-132 | 408 |
| LLPS-Lep-0994 | Leersia perrieri | 38.82 | 1e-64 | 233 |
| LLPS-Fec-1256 | Felis catus | 38.74 | 6e-139 | 427 |
| LLPS-Mod-3985 | Monodelphis domestica | 38.68 | 6e-136 | 420 |
| LLPS-Sah-3890 | Sarcophilus harrisii | 38.47 | 1e-127 | 398 |
| LLPS-Caf-1586 | Canis familiaris | 38.42 | 6e-137 | 422 |
| LLPS-Crn-1440 | Cryptococcus neoformans | 38.37 | 2e-138 | 426 |
| LLPS-Mum-0491 | Mus musculus | 38.33 | 8e-135 | 418 |
| LLPS-Meg-1439 | Meleagris gallopavo | 38.31 | 4e-136 | 421 |
| LLPS-Eqc-1592 | Equus caballus | 38.3 | 7e-137 | 423 |
| LLPS-Mup-2897 | Mustela putorius furo | 38.3 | 2e-136 | 424 |
| LLPS-Pyt-0028 | Pyrenophora teres | 38.3 | 2e-102 | 328 |
| LLPS-Sus-3113 | Sus scrofa | 38.29 | 2e-137 | 423 |
| LLPS-Myl-4103 | Myotis lucifugus | 38.2 | 1e-134 | 416 |
| LLPS-Ran-4213 | Rattus norvegicus | 38.17 | 1e-134 | 416 |
| LLPS-Urm-2552 | Ursus maritimus | 38.14 | 4e-137 | 424 |
| LLPS-Ova-4218 | Ovis aries | 38.14 | 3e-134 | 416 |
| LLPS-Bot-0746 | Bos taurus | 38.14 | 5e-134 | 415 |
| LLPS-Gaga-2832 | Gallus gallus | 38.02 | 6e-136 | 420 |
| LLPS-Cap-4590 | Cavia porcellus | 37.98 | 2e-135 | 418 |
| LLPS-Pes-3490 | Pelodiscus sinensis | 37.96 | 1e-129 | 402 |
| LLPS-Gog-4138 | Gorilla gorilla | 37.96 | 7e-137 | 422 |
| LLPS-Blg-0352 | Blumeria graminis | 37.94 | 2e-143 | 439 |
| LLPS-Miv-0117 | Microbotryum violaceum | 37.89 | 6e-137 | 422 |
| LLPS-Fud-1708 | Fukomys damarensis | 37.87 | 1e-135 | 419 |
| LLPS-Scc-1276 | Schizosaccharomyces cryophilus | 37.86 | 4e-128 | 398 |
| LLPS-Ict-0922 | Ictidomys tridecemlineatus | 37.83 | 8e-135 | 417 |
| LLPS-Pat-1347 | Pan troglodytes | 37.81 | 2e-136 | 421 |
| LLPS-Pap-4045 | Pan paniscus | 37.81 | 2e-136 | 421 |
| LLPS-Hos-3746 | Homo sapiens | 37.81 | 3e-136 | 421 |
| LLPS-Man-0324 | Macaca nemestrina | 37.81 | 2e-136 | 421 |
| LLPS-Caj-4545 | Callithrix jacchus | 37.81 | 9e-136 | 419 |
| LLPS-Chs-2575 | Chlorocebus sabaeus | 37.81 | 3e-136 | 421 |
| LLPS-Cea-3530 | Cercocebus atys | 37.81 | 2e-136 | 421 |
| LLPS-Paa-2272 | Papio anubis | 37.81 | 4e-136 | 420 |
| LLPS-Mal-1833 | Mandrillus leucophaeus | 37.81 | 2e-136 | 421 |
| LLPS-Ast-1535 | Aspergillus terreus | 37.73 | 1e-131 | 407 |
| LLPS-Tut-1316 | Tursiops truncatus | 37.72 | 8e-130 | 404 |
| LLPS-Mam-1463 | Macaca mulatta | 37.67 | 2e-135 | 419 |
| LLPS-Maf-2511 | Macaca fascicularis | 37.67 | 1e-135 | 419 |
| LLPS-Icp-2476 | Ictalurus punctatus | 37.59 | 4e-134 | 415 |
| LLPS-Leo-2563 | Lepisosteus oculatus | 37.59 | 1e-139 | 429 |
| LLPS-Nol-3862 | Nomascus leucogenys | 37.58 | 3e-126 | 394 |
| LLPS-Fia-1502 | Ficedula albicollis | 37.57 | 2e-135 | 419 |
| LLPS-Orc-0146 | Oryctolagus cuniculus | 37.57 | 7e-135 | 417 |
| LLPS-Ora-0398 | Ornithorhynchus anatinus | 37.53 | 2e-91 | 298 |
| LLPS-Pytr-0330 | Pyrenophora triticirepentis | 37.52 | 3e-134 | 415 |
| LLPS-Orl-2033 | Oryzias latipes | 37.52 | 7e-133 | 412 |
| LLPS-Anp-3208 | Anas platyrhynchos | 37.43 | 3e-134 | 416 |
| LLPS-Tag-0285 | Taeniopygia guttata | 37.43 | 2e-133 | 413 |
| LLPS-Asm-3832 | Astyanax mexicanus | 37.43 | 1e-133 | 414 |
| LLPS-Loa-4145 | Loxodonta africana | 37.37 | 6e-127 | 396 |
| LLPS-Pof-3407 | Poecilia formosa | 37.18 | 2e-133 | 414 |
| LLPS-Mel-1323 | Melampsora laricipopulina | 37.1 | 2e-138 | 426 |
| LLPS-Anc-1239 | Anolis carolinensis | 37.03 | 5e-114 | 360 |
| LLPS-Aon-4511 | Aotus nancymaae | 37.02 | 4e-111 | 354 |
| LLPS-Tar-1924 | Takifugu rubripes | 36.98 | 2e-120 | 379 |
| LLPS-Amt-0608 | Amborella trichopoda | 36.9 | 2e-129 | 403 |
| LLPS-Put-1080 | Puccinia triticina | 36.88 | 2e-136 | 422 |
| LLPS-Scm-1821 | Scophthalmus maximus | 36.81 | 2e-130 | 406 |
| LLPS-Scj-1296 | Schizosaccharomyces japonicus | 36.8 | 6e-130 | 402 |
| LLPS-Xim-0624 | Xiphophorus maculatus | 36.74 | 2e-132 | 411 |
| LLPS-Sot-2033 | Solanum tuberosum | 36.64 | 4e-127 | 397 |
| LLPS-Scf-2782 | Scleropages formosus | 36.6 | 4e-134 | 417 |
| LLPS-Orn-2918 | Oreochromis niloticus | 36.57 | 4e-132 | 410 |
| LLPS-Dio-2848 | Dipodomys ordii | 36.48 | 6e-127 | 396 |
| LLPS-Zyt-0499 | Zymoseptoria tritici | 36.46 | 3e-140 | 431 |
| LLPS-Thc-0546 | Theobroma cacao | 36.43 | 6e-125 | 392 |
| LLPS-Sol-1911 | Solanum lycopersicum | 36.43 | 4e-124 | 390 |
| LLPS-Spr-1435 | Sporisorium reilianum | 36.3 | 4e-142 | 437 |
| LLPS-Pot-0917 | Populus trichocarpa | 36.22 | 6e-128 | 399 |
| LLPS-Ten-0015 | Tetraodon nigroviridis | 36.16 | 5e-117 | 369 |
| LLPS-Osl-0936 | Ostreococcus lucimarinus | 36.06 | 3e-124 | 388 |
| LLPS-Sem-2442 | Selaginella moellendorffii | 36.06 | 3e-114 | 363 |
| LLPS-Met-1227 | Medicago truncatula | 36.06 | 3e-117 | 371 |
| LLPS-Gaa-3244 | Gasterosteus aculeatus | 36.04 | 5e-133 | 412 |
| LLPS-Art-2313 | Arabidopsis thaliana | 35.85 | 5e-128 | 399 |
| LLPS-Brr-2567 | Brassica rapa | 35.74 | 9e-128 | 398 |
| LLPS-Xet-3931 | Xenopus tropicalis | 35.73 | 6e-79 | 269 |
| LLPS-Usm-1218 | Ustilago maydis | 35.66 | 4e-137 | 424 |
| LLPS-Glm-2669 | Glycine max | 35.62 | 1e-123 | 387 |
| LLPS-Prp-2545 | Prunus persica | 35.59 | 1e-117 | 373 |
| LLPS-Brn-1511 | Brassica napus | 35.59 | 1e-127 | 398 |
| LLPS-Drm-2257 | Drosophila melanogaster | 35.49 | 2e-127 | 397 |
| LLPS-Mua-2511 | Musa acuminata | 35.41 | 1e-119 | 379 |
| LLPS-Arl-2358 | Arabidopsis lyrata | 35.41 | 6e-125 | 391 |
| LLPS-Php-1516 | Physcomitrella patens | 35.34 | 6e-121 | 380 |
| LLPS-Dac-1870 | Daucus carota | 35.32 | 2e-111 | 356 |
| LLPS-Nia-1737 | Nicotiana attenuata | 35.22 | 4e-123 | 387 |
| LLPS-Phv-2344 | Phaseolus vulgaris | 35.18 | 1e-120 | 380 |
| LLPS-Bro-2857 | Brassica oleracea | 35.15 | 2e-126 | 395 |
| LLPS-Viv-1414 | Vitis vinifera | 35.13 | 4e-119 | 379 |
| LLPS-Dar-2169 | Danio rerio | 35.12 | 1e-112 | 359 |
| LLPS-Rhb-3377 | Rhinopithecus bieti | 35.09 | 1e-112 | 357 |
| LLPS-Pug-0092 | Puccinia graminis | 35.05 | 4e-135 | 419 |
| LLPS-Gor-1402 | Gossypium raimondii | 35.02 | 3e-120 | 379 |
| LLPS-Lac-1165 | Latimeria chalumnae | 34.78 | 1e-90 | 298 |
| LLPS-Cae-2011 | Caenorhabditis elegans | 34.75 | 3e-115 | 364 |
| LLPS-Hea-1576 | Helianthus annuus | 34.64 | 2e-118 | 374 |
| LLPS-Vir-0935 | Vigna radiata | 34.11 | 7e-109 | 348 |
| LLPS-Coc-1982 | Corchorus capsularis | 33.63 | 1e-109 | 349 |
| LLPS-Cus-1835 | Cucumis sativus | 33.14 | 4e-114 | 363 |