• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Xim-2093
SRP54

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Signal recognition particle 54 kDa protein
Gene Name: SRP54
Ensembl Gene: ENSXMAG00000018315.2
Ensembl Protein: ENSXMAP00000038123.1
Organism: Xiphophorus maculatus
Taxa ID: 8083
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MVLADLGRKI  TSALRSLSNA  TIINEEVLNA  MLKEVCAALL  EADVNIKLVK  QLRENVKSAI  60
61    DLEEMASGLN  KRRMIQHAVF  KELVKLVDPG  VKAWTPTKGK  NNVIMFVGLQ  GSGKTTTCSK  120
121   LAYYYQRKGW  KTCLICADTF  RAGAFDQLKQ  NATKARIPFY  GSYTEMDPVV  IAAEGVEKFK  180
181   GENFEIIIVD  TSGRHKQEDS  LFEEMLQVSN  AVQPDNIVYV  MDASIGQACE  AQAKAFKDKV  240
241   DVASVIVTKL  DGHAKGGGAL  SAVAATRSPI  IFIGTGEHID  DFEPFKTQPF  ISKLLGMGDI  300
301   EGLIDRVNEL  KLDDNEELID  KLKHGQFTLR  DMYEQFQNIM  KMGPFGQIMG  MIPGFGTDFM  360
361   SKGNEQESMA  RLKKLMTIMD  SMNDQELDSK  DGAKLFSKQP  NRIQRVARGS  GVATRDVQEL  420
421   LTQYTKFAQM  VKKMGGIKGL  FKGGDMSKNV  NPSQMAKLNQ  QMAKMMDPRV  LHHMGGMAGL  480
481   QSMMRQFQQG  AAGNMKGMMG  FNNM  504
Nucleotide CDS Sequence (FASTA)
1     ATGGTGCTGG  CCGACCTGGG  AAGGAAGATC  ACCTCGGCGC  TGAGGTCACT  CAGCAACGCC  60
61    ACCATCATCA  ATGAAGAGGT  GTTGAACGCC  ATGTTGAAGG  AGGTGTGTGC  TGCTCTCCTG  120
121   GAGGCAGACG  TTAACATCAA  ACTGGTCAAA  CAACTGAGGG  AAAACGTCAA  GTCCGCCATA  180
181   GACCTGGAGG  AGATGGCCTC  AGGCCTGAAC  AAGAGGAGGA  TGATCCAACA  CGCTGTGTTC  240
241   AAGGAGCTGG  TGAAGCTGGT  CGATCCCGGC  GTGAAGGCCT  GGACTCCGAC  TAAAGGCAAG  300
301   AACAACGTCA  TCATGTTTGT  TGGTCTGCAA  GGCAGTGGCA  AAACTACAAC  CTGCTCCAAG  360
361   CTCGCTTATT  ATTACCAGAG  AAAAGGCTGG  AAGACCTGCC  TGATCTGCGC  CGACACCTTC  420
421   AGAGCAGGTG  CCTTCGATCA  GCTCAAACAA  AACGCCACCA  AAGCCAGAAT  ACCTTTTTAT  480
481   GGCAGTTACA  CTGAGATGGA  TCCTGTGGTG  ATCGCCGCAG  AAGGCGTCGA  GAAATTCAAA  540
541   GGCGAAAACT  TTGAGATCAT  CATCGTGGAC  ACAAGTGGAA  GACACAAACA  GGAGGATTCA  600
601   CTGTTTGAGG  AGATGCTGCA  AGTCTCCAAC  GCAGTGCAAC  CTGATAACAT  TGTGTACGTG  660
661   ATGGATGCTT  CCATCGGTCA  GGCCTGCGAA  GCCCAGGCTA  AAGCTTTCAA  AGACAAAGTG  720
721   GACGTAGCGT  CGGTCATCGT  CACAAAGCTA  GATGGACACG  CCAAAGGAGG  CGGAGCTTTG  780
781   AGCGCTGTGG  CGGCCACCAG  GAGTCCCATC  ATCTTCATCG  GAACAGGGGA  ACACATCGAC  840
841   GACTTCGAGC  CGTTTAAGAC  TCAGCCTTTC  ATCAGCAAAC  TGCTGGGAAT  GGGTGATATT  900
901   GAAGGACTGA  TCGACAGAGT  GAACGAGCTA  AAGCTGGATG  ACAACGAGGA  GCTGATAGAC  960
961   AAACTGAAAC  ATGGTCAGTT  CACGCTCAGG  GACATGTACG  AGCAGTTCCA  GAACATCATG  1020
1021  AAGATGGGGC  CCTTCGGACA  AATTATGGGT  ATGATTCCCG  GTTTTGGTAC  AGATTTCATG  1080
1081  AGTAAAGGAA  ACGAACAGGA  ATCAATGGCC  AGATTGAAGA  AACTCATGAC  CATCATGGAC  1140
1141  AGCATGAATG  ACCAGGAACT  GGACAGTAAA  GATGGGGCGA  AGCTGTTCAG  TAAGCAGCCC  1200
1201  AACCGGATCC  AGAGAGTGGC  CCGTGGATCT  GGAGTTGCCA  CCAGAGACGT  TCAGGAGTTA  1260
1261  CTCACTCAGT  ACACTAAGTT  TGCTCAGATG  GTGAAGAAGA  TGGGAGGCAT  CAAAGGACTA  1320
1321  TTCAAAGGAG  GAGACATGTC  CAAAAACGTG  AACCCATCTC  AGATGGCCAA  ACTGAACCAG  1380
1381  CAGATGGCCA  AAATGATGGA  CCCTCGGGTC  CTGCATCATA  TGGGGGGCAT  GGCTGGCCTT  1440
1441  CAGTCCATGA  TGCGCCAGTT  CCAGCAAGGA  GCAGCCGGCA  ACATGAAAGG  CATGATGGGA  1500
1501  TTTAACAACA  TGTGA  1515

▼ KEYWORD

ID
Family
Complete proteome
Cytoplasm
GTP-binding
Nucleotide-binding
Reference proteome
Ribonucleoprotein
RNA-binding
Signal recognition particle

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Signal recognition particle, endoplasmic reticulum targeting
Molecular Function
7S RNA binding
Molecular Function
GTP binding
Molecular Function
GTPase activity
Biological Process
Exocrine pancreas development
Biological Process
Neutrophil chemotaxis
Biological Process
SRP-dependent cotranslational protein targeting to membrane

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pof-4068Poecilia formosa100.00.01010
LLPS-Orn-0887Oreochromis niloticus99.390.01006
LLPS-Orl-3742Oryzias latipes99.180.01005
LLPS-Gaa-3699Gasterosteus aculeatus98.980.01004
LLPS-Tar-1524Takifugu rubripes98.770.0 999
LLPS-Dar-3684Danio rerio98.570.0 999
LLPS-Leo-1108Lepisosteus oculatus98.160.0 995
LLPS-Ten-3616Tetraodon nigroviridis97.960.0 993
LLPS-Asm-4025Astyanax mexicanus97.750.0 996
LLPS-Icp-4246Ictalurus punctatus97.750.0 996
LLPS-Scf-3865Scleropages formosus96.560.0 975
LLPS-Mum-3713Mus musculus96.110.0 978
LLPS-Mea-2106Mesocricetus auratus96.110.0 978
LLPS-Caf-2957Canis familiaris95.910.0 976
LLPS-Eqc-3130Equus caballus95.910.0 978
LLPS-Ict-3800Ictidomys tridecemlineatus95.910.0 976
LLPS-Hos-3877Homo sapiens95.910.0 976
LLPS-Pat-0324Pan troglodytes95.910.0 976
LLPS-Urm-1238Ursus maritimus95.910.0 976
LLPS-Pap-1642Pan paniscus95.910.0 976
LLPS-Mod-0623Monodelphis domestica95.910.0 975
LLPS-Loa-1849Loxodonta africana95.910.0 976
LLPS-Otg-3775Otolemur garnettii95.910.0 976
LLPS-Bot-2326Bos taurus95.910.0 976
LLPS-Ran-4594Rattus norvegicus95.910.0 976
LLPS-Mup-3007Mustela putorius furo95.910.0 976
LLPS-Aim-0867Ailuropoda melanoleuca95.910.0 976
LLPS-Ova-3930Ovis aries95.910.0 976
LLPS-Chs-4545Chlorocebus sabaeus95.910.0 976
LLPS-Ora-0966Ornithorhynchus anatinus95.910.0 976
LLPS-Sus-2767Sus scrofa95.910.0 976
LLPS-Gog-4256Gorilla gorilla95.910.0 976
LLPS-Fud-2033Fukomys damarensis95.910.0 976
LLPS-Mam-1419Macaca mulatta95.780.0 944
LLPS-Nol-2860Nomascus leucogenys95.780.0 947
LLPS-Man-2137Macaca nemestrina95.780.0 944
LLPS-Paa-1582Papio anubis95.780.0 943
LLPS-Mal-3554Mandrillus leucophaeus95.780.0 943
LLPS-Maf-3762Macaca fascicularis95.780.0 944
LLPS-Cea-2704Cercocebus atys95.780.0 943
LLPS-Aon-4318Aotus nancymaae95.780.0 947
LLPS-Caj-3593Callithrix jacchus95.780.0 947
LLPS-Fec-2719Felis catus95.710.0 974
LLPS-Pes-1361Pelodiscus sinensis95.710.0 978
LLPS-Cas-1528Carlito syrichta95.570.0 944
LLPS-Cap-2083Cavia porcellus95.50.0 969
LLPS-Gaga-0234Gallus gallus95.50.0 977
LLPS-Lac-3770Latimeria chalumnae95.50.0 973
LLPS-Fia-3414Ficedula albicollis95.50.0 977
LLPS-Tag-1660Taeniopygia guttata95.360.0 947
LLPS-Anp-1365Anas platyrhynchos95.360.0 947
LLPS-Anc-2372Anolis carolinensis95.30.0 971
LLPS-Orc-1097Oryctolagus cuniculus95.30.0 962
LLPS-Myl-3591Myotis lucifugus95.30.0 970
LLPS-Sah-1441Sarcophilus harrisii94.820.0 646
LLPS-Scm-3067Scophthalmus maximus93.060.0 984
LLPS-Meg-0282Meleagris gallopavo90.840.0 929
LLPS-Poa-3799Pongo abelii90.80.0 920
LLPS-Cis-1231Ciona savignyi90.12e-55 188
LLPS-Cii-0400Ciona intestinalis84.220.0 855
LLPS-Dio-2092Dipodomys ordii80.750.0 722
LLPS-Xet-1689Xenopus tropicalis80.080.0 792
LLPS-Drm-1984Drosophila melanogaster79.180.0 808
LLPS-Cae-1098Caenorhabditis elegans73.820.0 763
LLPS-Cog-0402Colletotrichum gloeosporioides59.618e-177 514
LLPS-Sem-1278Selaginella moellendorffii59.470.0 598
LLPS-Map-1243Magnaporthe poae59.40.0 545
LLPS-Nia-1641Nicotiana attenuata59.390.0 596
LLPS-Tum-0626Tuber melanosporum59.310.0 546
LLPS-Orr-1382Oryza rufipogon59.180.0 590
LLPS-Orm-1285Oryza meridionalis59.180.0 591
LLPS-Org-0268Oryza glaberrima59.180.0 591
LLPS-Ors-0689Oryza sativa59.180.0 590
LLPS-Orgl-0212Oryza glumaepatula59.180.0 591
LLPS-Lep-1160Leersia perrieri59.180.0 590
LLPS-Orb-1817Oryza barthii59.180.0 591
LLPS-Abg-0838Absidia glauca59.150.0 598
LLPS-Orp-0327Oryza punctata58.980.0 588
LLPS-Sob-2301Sorghum bicolor58.980.0 590
LLPS-Orbr-1965Oryza brachyantha58.980.0 588
LLPS-Phv-1889Phaseolus vulgaris58.980.0 596
LLPS-Mae-1608Manihot esculenta58.980.0 598
LLPS-Sei-2463Setaria italica58.980.0 591
LLPS-Ori-0526Oryza indica58.980.0 587
LLPS-Mua-2149Musa acuminata58.980.0 593
LLPS-Orni-2138Oryza nivara58.980.0 587
LLPS-Nec-1537Neurospora crassa58.940.0 538
LLPS-Cogr-1343Colletotrichum graminicola58.720.0 543
LLPS-Mao-1452Magnaporthe oryzae58.720.0 533
LLPS-Gag-0096Gaeumannomyces graminis58.694e-180 523
LLPS-Glm-0567Glycine max58.570.0 588
LLPS-Zem-0958Zea mays58.50.0 584
LLPS-Sol-1202Solanum lycopersicum58.370.0 590
LLPS-Thc-1585Theobroma cacao58.370.0 592
LLPS-Ved-1513Verticillium dahliae58.310.0 536
LLPS-Tru-0949Triticum urartu58.280.0 586
LLPS-Tra-1589Triticum aestivum58.280.0 585
LLPS-Blg-1294Blumeria graminis58.260.0 538
LLPS-Gor-1679Gossypium raimondii58.160.0 592
LLPS-Pot-1197Populus trichocarpa58.160.0 593
LLPS-Sot-0923Solanum tuberosum58.160.0 588
LLPS-Hov-2188Hordeum vulgare58.080.0 585
LLPS-Coc-2013Corchorus capsularis57.960.0 587
LLPS-Prp-2507Prunus persica57.960.0 588
LLPS-Cus-1598Cucumis sativus57.760.0 587
LLPS-Hea-1336Helianthus annuus57.760.0 587
LLPS-Via-2121Vigna angularis57.550.0 576
LLPS-Met-1348Medicago truncatula57.460.0 587
LLPS-Viv-2089Vitis vinifera57.350.0 585
LLPS-Amt-1934Amborella trichopoda57.350.0 580
LLPS-Fuo-1346Fusarium oxysporum57.340.0 531
LLPS-Scj-0672Schizosaccharomyces japonicus57.330.0 558
LLPS-Brd-0954Brachypodium distachyon57.260.0 579
LLPS-Bro-2132Brassica oleracea57.140.0 581
LLPS-Brr-2907Brassica rapa57.140.0 579
LLPS-Brn-0870Brassica napus57.140.0 579
LLPS-Fuv-1322Fusarium verticillioides57.110.0 529
LLPS-Yal-0881Yarrowia lipolytica57.085e-173 506
LLPS-Dac-0093Daucus carota57.030.0 572
LLPS-Art-1243Arabidopsis thaliana56.940.0 578
LLPS-Zyt-1085Zymoseptoria tritici56.884e-167 490
LLPS-Fus-1267Fusarium solani56.422e-178 519
LLPS-Arl-2885Arabidopsis lyrata56.420.0 570
LLPS-Phn-1506Phaeosphaeria nodorum56.171e-176 515
LLPS-Coo-1301Colletotrichum orbiculare56.160.0 543
LLPS-Scc-1567Schizosaccharomyces cryophilus56.080.0 546
LLPS-Scp-0921Schizosaccharomyces pombe56.010.0 526
LLPS-Dos-0500Dothistroma septosporum55.897e-172 502
LLPS-Lem-0220Leptosphaeria maculans55.772e-174 509
LLPS-Vir-0727Vigna radiata55.510.0 552
LLPS-Pyt-0500Pyrenophora teres55.119e-173 505
LLPS-Miv-0542Microbotryum violaceum54.996e-153 457
LLPS-Chc-0929Chondrus crispus54.690.0 560
LLPS-Scs-0189Sclerotinia sclerotiorum54.682e-177 517
LLPS-Gas-1028Galdieria sulphuraria54.620.0 568
LLPS-Pytr-1071Pyrenophora triticirepentis53.863e-149 443
LLPS-Asni-1318Aspergillus niger53.192e-169 496
LLPS-Trr-0623Trichoderma reesei53.112e-177 516
LLPS-Crn-1525Cryptococcus neoformans53.112e-176 516
LLPS-Beb-0243Beauveria bassiana53.090.0 529
LLPS-Asfu-0399Aspergillus fumigatus53.081e-172 504
LLPS-Aso-1048Aspergillus oryzae53.087e-171 500
LLPS-Asf-1275Aspergillus flavus53.086e-171 500
LLPS-Asn-1302Aspergillus nidulans52.931e-168 494
LLPS-Asc-0929Aspergillus clavatus52.866e-171 500
LLPS-Ast-1243Aspergillus terreus52.751e-172 504
LLPS-Nef-1497Neosartorya fischeri52.488e-169 494
LLPS-Kop-0946Komagataella pastoris52.195e-171 500
LLPS-Sac-1434Saccharomyces cerevisiae51.76e-153 455
LLPS-Trv-0915Trichoderma virens51.694e-177 516
LLPS-Osl-1185Ostreococcus lucimarinus51.22e-178 519
LLPS-Chr-0266Chlamydomonas reinhardtii50.511e-169 496
LLPS-Asg-1299Ashbya gossypii50.218e-159 469
LLPS-Cym-1051Cyanidioschyzon merolae50.24e-180 523
LLPS-Spr-1075Sporisorium reilianum49.66e-156 466
LLPS-Pug-1376Puccinia graminis49.482e-151 454
LLPS-Mel-1233Melampsora laricipopulina49.479e-153 457
LLPS-Put-0638Puccinia triticina49.121e-140 427
LLPS-Php-1875Physcomitrella patens48.423e-130 393
LLPS-Usm-0564Ustilago maydis46.562e-158 472