• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Xim-0150

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Nitric oxide synthase-interacting protein
Ensembl Gene: ENSXMAG00000002594.2
Ensembl Protein: ENSXMAP00000002601.2
Organism: Xiphophorus maculatus
Taxa ID: 8083
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nuclear speckle, Nucleolus, Stress granulePredicted from orthologs(View)

▼ FUNCTION

Negatively regulates nitric oxide production by inducing nitric oxide synthase translocation to actin cytoskeleton and inhibiting its enzymatic activity.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MTRHGKNCTA  GAVYTYHEKR  KDTAASGYGT  QSVRLGKDAI  KDFDCCCLSL  QPCQDPVVTP  60
61    DGYLYEKQAI  LEYILHQKTE  IAKKMKAYEK  QKQALKSTNQ  LESKSEERQR  VERFKTSENS  120
121   IVSKPINPFT  SGQKKESEAS  SSGEASTASP  APSSSQSLPS  FWIPSLTPES  KPTLLKKPSK  180
181   AVLCPMSGRP  IKMNDLIPVN  FTPLDSSLDR  VALLNRQERY  VCAVTRDALG  NSVPCVVLRP  240
241   SGTVVTQECV  EKLIKKDMTD  PVSGAKLTER  DIVPLQRGGT  GFAGSGVDLR  AKEARPVMQA  300
Nucleotide CDS Sequence (FASTA)
1     ATGACTCGAC  ATGGGAAGAA  CTGCACAGCC  GGAGCTGTTT  ATACTTACCA  TGAGAAGAGG  60
61    AAGGACACAG  CGGCGTCTGG  TTATGGAACC  CAGAGCGTCC  GTCTGGGAAA  AGATGCTATC  120
121   AAAGACTTTG  ACTGCTGCTG  CCTGTCCCTG  CAGCCCTGCC  AGGACCCTGT  GGTGACCCCA  180
181   GATGGATATT  TGTATGAAAA  GCAGGCCATT  CTTGAATACA  TTCTGCACCA  GAAGACAGAA  240
241   ATAGCCAAAA  AGATGAAGGC  GTATGAGAAG  CAGAAGCAAG  CTCTGAAGAG  CACCAACCAG  300
301   CTGGAGTCCA  AGTCTGAGGA  ACGGCAGAGG  GTGGAGAGGT  TTAAGACCAG  CGAGAACAGC  360
361   ATCGTGTCCA  AACCCATCAA  CCCGTTCACA  TCCGGGCAGA  AGAAGGAGAG  TGAAGCGAGC  420
421   AGCTCAGGAG  AGGCGTCCAC  TGCGAGTCCA  GCCCCCTCCT  CCAGCCAGAG  CCTGCCCAGC  480
481   TTCTGGATCC  CCTCTCTGAC  CCCAGAGTCC  AAGCCCACCC  TTCTGAAGAA  ACCCAGTAAA  540
541   GCTGTGCTGT  GTCCCATGTC  TGGGCGACCC  ATAAAGATGA  ATGACCTGAT  CCCAGTGAAC  600
601   TTCACCCCAC  TGGACTCAAG  CCTGGACAGG  GTGGCCTTGC  TAAACCGCCA  GGAGAGGTAC  660
661   GTGTGTGCAG  TGACCAGAGA  CGCTCTGGGT  AACAGTGTCC  CCTGCGTCGT  CCTGAGACCC  720
721   TCAGGGACTG  TAGTGACTCA  GGAGTGTGTG  GAGAAGTTGA  TAAAGAAGGA  CATGACTGAC  780
781   CCCGTGTCTG  GAGCCAAACT  AACAGAGAGA  GACATCGTCC  CACTGCAGAG  GGGTGGAACC  840
841   GGCTTCGCAG  GCTCTGGAGT  TGACCTGAGA  GCCAAAGAGG  CCCGTCCAGT  GATGCAGGCA  900
901   TGA  903

▼ KEYWORD

ID
Family
Coiled coil
Complete proteome
Cytoplasm
Nucleus
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Nucleus
Molecular Function
Ubiquitin protein ligase activity

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ten-0602Tetraodon nigroviridis96.612e-35 128
LLPS-Pof-0320Poecilia formosa95.750.0 533
LLPS-Ora-3006Ornithorhynchus anatinus89.831e-32 123
LLPS-Urm-3067Ursus maritimus83.931e-27 107
LLPS-Orn-1057Oreochromis niloticus83.441e-168 478
LLPS-Orl-1757Oryzias latipes82.675e-155 443
LLPS-Scm-1575Scophthalmus maximus81.912e-151 434
LLPS-Asm-1552Astyanax mexicanus78.254e-157 448
LLPS-Gaa-0690Gasterosteus aculeatus77.998e-166 471
LLPS-Tar-1312Takifugu rubripes77.485e-160 456
LLPS-Dar-2704Danio rerio77.32e-164 467
LLPS-Leo-1306Lepisosteus oculatus75.924e-152 435
LLPS-Icp-0135Ictalurus punctatus75.321e-157 450
LLPS-Scf-1084Scleropages formosus73.462e-161 459
LLPS-Gog-0139Gorilla gorilla72.595e-64 211
LLPS-Anc-0114Anolis carolinensis68.03e-137 397
LLPS-Ict-0731Ictidomys tridecemlineatus66.451e-134 391
LLPS-Caj-1885Callithrix jacchus66.453e-137 398
LLPS-Otg-0643Otolemur garnettii66.231e-133 388
LLPS-Fec-0639Felis catus66.116e-136 394
LLPS-Mam-1666Macaca mulatta66.112e-134 394
LLPS-Poa-0266Pongo abelii66.113e-135 394
LLPS-Sus-1222Sus scrofa66.111e-135 394
LLPS-Cea-0537Cercocebus atys66.111e-135 393
LLPS-Maf-0792Macaca fascicularis66.111e-135 393
LLPS-Mal-1804Mandrillus leucophaeus66.111e-135 393
LLPS-Mup-0119Mustela putorius furo66.019e-135 394
LLPS-Aon-0483Aotus nancymaae65.86e-136 394
LLPS-Hos-1946Homo sapiens65.792e-136 395
LLPS-Pat-2469Pan troglodytes65.793e-136 395
LLPS-Nol-0565Nomascus leucogenys65.792e-136 395
LLPS-Myl-0804Myotis lucifugus65.792e-136 395
LLPS-Eqc-2465Equus caballus65.784e-135 392
LLPS-Chs-3822Chlorocebus sabaeus65.781e-134 392
LLPS-Tut-0858Tursiops truncatus65.782e-135 393
LLPS-Loa-0537Loxodonta africana65.682e-134 390
LLPS-Lac-0518Latimeria chalumnae65.582e-131 383
LLPS-Pap-0241Pan paniscus65.461e-135 393
LLPS-Fud-0759Fukomys damarensis65.381e-57 188
LLPS-Dio-1233Dipodomys ordii65.353e-132 385
LLPS-Caf-1896Canis familiaris65.126e-133 391
LLPS-Mod-3140Monodelphis domestica64.784e-133 387
LLPS-Sah-0787Sarcophilus harrisii64.674e-133 387
LLPS-Cap-2331Cavia porcellus64.593e-133 387
LLPS-Ran-0239Rattus norvegicus64.451e-130 381
LLPS-Orc-1054Oryctolagus cuniculus64.292e-120 354
LLPS-Mum-2329Mus musculus64.121e-129 378
LLPS-Ova-1121Ovis aries63.911e-127 373
LLPS-Aim-1439Ailuropoda melanoleuca63.693e-131 383
LLPS-Bot-3954Bos taurus63.087e-115 343
LLPS-Paa-1104Papio anubis62.958e-135 392
LLPS-Xet-0618Xenopus tropicalis62.072e-133 389
LLPS-Mea-3521Mesocricetus auratus54.692e-52 176
LLPS-Rhb-2459Rhinopithecus bieti53.642e-69 223
LLPS-Cis-1592Ciona savignyi52.942e-42 150
LLPS-Cii-0809Ciona intestinalis52.827e-97 295
LLPS-Gas-0755Galdieria sulphuraria51.044e-24 103
LLPS-Cas-1547Carlito syrichta49.171e-79 249
LLPS-Drm-0894Drosophila melanogaster45.134e-87 270
LLPS-Cae-1492Caenorhabditis elegans39.815e-68 221
LLPS-Tum-0761Tuber melanosporum35.712e-0652.4
LLPS-Mao-0034Magnaporthe oryzae33.012e-0756.2
LLPS-Cog-0043Colletotrichum gloeosporioides32.612e-0755.5
LLPS-Lep-1400Leersia perrieri32.52e-2094.0
LLPS-Chr-0201Chlamydomonas reinhardtii32.447e-33 129
LLPS-Nia-1564Nicotiana attenuata32.421e-34 133
LLPS-Sob-0199Sorghum bicolor32.429e-35 133
LLPS-Orgl-0015Oryza glumaepatula32.423e-33 129
LLPS-Sei-0908Setaria italica32.422e-32 127
LLPS-Mae-0407Manihot esculenta32.25e-35 134
LLPS-Cus-1435Cucumis sativus32.25e-33 129
LLPS-Pot-1012Populus trichocarpa32.082e-32 127
LLPS-Ors-1003Oryza sativa32.084e-33 129
LLPS-Orr-1330Oryza rufipogon32.084e-33 129
LLPS-Orm-0353Oryza meridionalis32.084e-33 129
LLPS-Org-1442Oryza glaberrima32.085e-33 129
LLPS-Zem-0651Zea mays32.082e-33 130
LLPS-Orb-0152Oryza barthii32.085e-33 129
LLPS-Ori-0866Oryza indica32.084e-33 129
LLPS-Orni-1818Oryza nivara32.084e-33 129
LLPS-Pytr-0678Pyrenophora triticirepentis31.785e-0651.6
LLPS-Orp-1565Oryza punctata31.741e-34 133
LLPS-Hov-0004Hordeum vulgare31.744e-34 132
LLPS-Brd-1498Brachypodium distachyon31.748e-33 128
LLPS-Mua-0895Musa acuminata31.538e-32 125
LLPS-Sol-0636Solanum lycopersicum31.42e-31 124
LLPS-Sot-1051Solanum tuberosum31.47e-32 125
LLPS-Tra-1191Triticum aestivum31.43e-32 126
LLPS-Tru-0214Triticum urartu31.374e-24 105
LLPS-Viv-0175Vitis vinifera31.191e-33 130
LLPS-Met-2126Medicago truncatula31.193e-30 121
LLPS-Hea-0013Helianthus annuus30.824e-31 123
LLPS-Sem-1484Selaginella moellendorffii30.743e-32 126
LLPS-Chc-0010Chondrus crispus30.694e-31 123
LLPS-Coc-0724Corchorus capsularis30.512e-31 124
LLPS-Amt-0300Amborella trichopoda30.411e-26 111
LLPS-Gor-0456Gossypium raimondii30.384e-32 126
LLPS-Thc-0724Theobroma cacao30.29e-32 125
LLPS-Via-0703Vigna angularis30.174e-32 126
LLPS-Php-1464Physcomitrella patens30.11e-32 128
LLPS-Orbr-1567Oryza brachyantha30.032e-32 127
LLPS-Phv-1159Phaseolus vulgaris29.837e-33 128
LLPS-Glm-0193Glycine max29.832e-30 122
LLPS-Vir-0084Vigna radiata29.831e-31 125
LLPS-Trr-0198Trichoderma reesei29.364e-0755.1
LLPS-Dac-1567Daucus carota29.351e-30 122
LLPS-Trv-0722Trichoderma virens29.097e-0753.9
LLPS-Art-0253Arabidopsis thaliana29.02e-26 110
LLPS-Brr-0214Brassica rapa28.951e-26 110
LLPS-Bro-0720Brassica oleracea28.951e-26 110
LLPS-Brn-1661Brassica napus28.951e-26 110
LLPS-Prp-0401Prunus persica28.473e-28 115
LLPS-Lem-0401Leptosphaeria maculans28.073e-0652.4
LLPS-Gag-1408Gaeumannomyces graminis28.032e-0653.1
LLPS-Ved-0816Verticillium dahliae27.875e-0960.5
LLPS-Mel-1057Melampsora laricipopulina27.766e-1989.0
LLPS-Pug-0958Puccinia graminis27.472e-1991.3
LLPS-Miv-0675Microbotryum violaceum27.194e-1680.9
LLPS-Arl-1730Arabidopsis lyrata27.063e-26 110
LLPS-Osl-0445Ostreococcus lucimarinus26.378e-26 108
LLPS-Cogr-0125Colletotrichum graminicola26.279e-0857.0
LLPS-Beb-0659Beauveria bassiana26.091e-0653.1