LLPS-Xet-a554
tamm41
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Phosphatidate cytidylyltransferase, mitochondrial; CDP-diacylglycerol synthase; Mitochondrial translocator assembly and maintenance protein 41 homolog |
| Gene Name: | tamm41 |
| Ensembl Gene: | ENSXETG00000015634.3 |
| Ensembl Protein: | ENSXETP00000034106.3 |
| Organism: | Xenopus tropicalis |
| Taxa ID: | 8364 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSXETT00000034106.3 | ENSXETP00000034106.3 |
| UniProt | F6UIL5, F6UIL5_XENTR | |
| GeneBank | AAMC01118361, AAMC01118356, AAMC01118360, AAMC01118359, AAMC01118358, AAMC01118357 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 QNKMLDFVFA VDDPVTWHTM NIIQNRSHYS FLKFLGPKHI AAVQNNYGAG IYYNTLVPCD 60 61 GRLIKYGVVG TETLLEDLLH WKTLYIAGRL HKPVKILTQR DEGRLHTALS TNLKSALTAA 120 121 FLMLPESFSE EELYLQIAGL SYAGGDFRMI IGEDKDKVLN IVKPNVPHFQ KLYAPILQDC 180 181 PLAVYKAKQG RVEVDKSPEG QYQQLMALPK KLQQNMAALV DPPGKNRDVE EILLQVAQDP 240 241 DCGNVVQQAL YGIVRSSSVS QSAKGILTAG FSYSSPVGEM QFYPLHHLLS RGRV 294 |
| Nucleotide CDS Sequence (FASTA) |
1 CAGAACAAGA TGTTGGACTT TGTATTTGCT GTTGACGACC CAGTGACTTG GCACACGATG 60 61 AATATCATTC AGAACCGGAG TCATTACTCT TTCCTCAAGT TCCTGGGCCC AAAACACATC 120 121 GCTGCCGTCC AGAACAACTA CGGCGCCGGC ATCTATTATA ATACCCTGGT GCCCTGCGAT 180 181 GGCAGACTGA TAAAGTACGG AGTCGTGGGC ACCGAGACGC TGCTGGAGGA TTTGCTGCAC 240 241 TGGAAGACGC TGTACATTGC GGGGCGTCTC CACAAACCGG TGAAAATCCT GACCCAGCGG 300 301 GACGAGGGGC GGCTCCACAC AGCCCTGAGC ACCAATCTGA AGAGTGCGCT GACTGCCGCC 360 361 TTCCTTATGC TCCCCGAAAG CTTCTCTGAG GAGGAACTGT ACCTGCAGAT TGCGGGGCTC 420 421 TCCTACGCCG GTGGAGACTT TCGCATGATT ATTGGGGAGG ACAAGGACAA AGTGCTGAAC 480 481 ATAGTGAAGC CGAACGTGCC CCATTTCCAG AAGCTCTACG CCCCCATCCT GCAGGATTGC 540 541 CCCCTGGCAG TGTACAAAGC AAAGCAGGGC AGAGTGGAGG TGGATAAGAG CCCCGAGGGG 600 601 CAGTACCAGC AGCTGATGGC TTTGCCCAAG AAGCTGCAGC AGAACATGGC GGCGCTTGTT 660 661 GACCCCCCAG GGAAGAACCG GGACGTGGAG GAGATTTTAC TGCAGGTGGC GCAGGACCCC 720 721 GATTGTGGGA ATGTGGTGCA GCAGGCTCTC TATGGTATTG TCAGGTCCTC CAGCGTCTCT 780 781 CAGAGCGCCA AGGGCATCCT TACTGCGGGT TTCTCATATT CATCCCCTGT AGGGGAGATG 840 841 CAGTTCTACC CTCTCCATCA CTTATTATCC AGGGGGAGGG TG 882 |
▼ KEYWORD
ID | Family |
Complete proteome | |
Lipid biosynthesis | |
Lipid metabolism | |
Magnesium | |
Membrane | |
Mitochondrion | |
Mitochondrion inner membrane | |
Nucleotidyltransferase | |
Phospholipid biosynthesis | |
Phospholipid metabolism | |
Reference proteome | |
Transferase
|
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Mitochondrial inner membrane | |
Molecular Function | Phosphatidate cytidylyltransferase activity | |
Biological Process | Cardiolipin biosynthetic process | |
Biological Process | CDP-diacylglycerol biosynthetic process |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Mum-a641 | Mus musculus | 4e-129 | 380 | undefined |
| LLPS-Hos-a647 | Homo sapiens | 5e-132 | 392 | undefined |