LLPS-Xet-3406
dlg1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Disks large homolog 1 |
| Gene Name: | dlg1, TEgg018e06.1 |
| Ensembl Gene: | ENSXETG00000003464.3 |
| Ensembl Protein: | ENSXETP00000027852.3 |
| Organism: | Xenopus tropicalis |
| Taxa ID: | 8364 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Essential multidomain scaffolding protein required for normal development. Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction and cell proliferation (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSXETT00000027852.3 | ENSXETP00000027852.3 |
| Ensembl | ENSXETT00000027854.3 | ENSXETP00000027854.3 |
| Ensembl | ENSXETT00000007496.3 | ENSXETP00000007496.3 |
| UniProt | Q28C55, DLG1_XENTR, B1H2J2 | |
| GeneBank | BC161021, CR942446 | AAI61021.1, CAJ82322.1 |
| RefSeq | NM_001045651.1 | NP_001039116.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MPVRKQDTQR ALTLLEEYRC KLHQTEDKQL RKSIERVIGI FQSNLFQALI DIQEFYEVTL 60 61 LDNPKSSDNA KPTEPVQTIN TWEYSSLPNS TATCETLPSS LILNVEKYRY PDDDITSQEP 120 121 SSPHMLNDGR NVELVQISEK NISQKENIQG LVSHSLISPL KTPEADTPCP PIVPVIPVIP 180 181 VPAESNVIPS STPQANPPPV IVNTDLETPA YVNGTDAEYE YEEITLERGT SGLGFSIAGG 240 241 TDNPHIGDDI SIFITKIISG GAAAQDGRLR VNDCILRVNE VDVHDVTHSK AVEALKEAGS 300 301 IVRLYVRRRK PVTEKIMDIK LVKGPKGLGF SIAGGVGNQH IPGDNSIYVT KIIEGGAAHK 360 361 DGRLQIGDKL LAVNTVCLEE VSHEDAVTAL KNTSDFVNLK VAKPTTMYMN DNYAPPDITN 420 421 SYSQQVDNHI SPSGFIGHPL PPSPGRYSPA PKGMLEDDDL TREPRKVVLQ RGTTGLGFNI 480 481 VGGEDGEGIF ISFILAGGPA DLSGELQKGD RIMSVNGVDL KSATHEQAAA ALKNAGQTVT 540 541 IVAQYRPEEY SRFEAKIHDL REQMMNSSIS SGSGSLRTSQ KRSLYVRALF DYDKTKDSGL 600 601 PSQGLNFKFG DILHVVNASD DEWWQARQVT ADGESEEIGV IPSKRRVEKK ERARLKTVKF 660 661 NSKARGDKGQ SFNDKRKKNL FSRKFPFYKN KDQSEMETSD VDRKVCSKMP CYSESYSGQE 720 721 EYVLSYEPVN QQEVNYSRPV IILGPTKDRV NDDLISEFPE KFGSCVPHTT RPKRDYEIDG 780 781 RDYHFVTSRE QMEKDIQDHR FIEAGQYNSH LYGTSVQSVK EVAERGKHCI LDVSGNAIKR 840 841 LQIAQLYPIA IFIKPKSVEN IIEMSKRVTE EQGRKTYERA MKLEQEFTEH FTAIVQGDTL 900 901 EEIYNQIKQI IEEQSSTFIW VPAKEKL 927 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGCCTGTCA GGAAGCAAGA TACTCAGCGT GCATTGACCC TTCTGGAAGA ATACCGCTGC 60 61 AAACTTCACC AAACTGAAGA CAAACAACTC AGGAAATCTA TTGAGCGTGT AATTGGCATC 120 121 TTTCAGAGCA ATCTTTTCCA AGCTCTTATA GATATACAGG AATTTTATGA AGTGACCTTA 180 181 CTGGACAACC CTAAATCTAG TGACAATGCT AAGCCGACTG AACCAGTGCA GACTATAAAT 240 241 ACATGGGAGT ATTCCAGCCT TCCTAACTCA ACAGCAACTT GTGAAACTCT ACCAAGCAGC 300 301 CTTATTTTAA ATGTTGAGAA ATATCGATAT CCTGATGATG ATATCACGTC ACAAGAGCCC 360 361 AGTTCCCCAC ACATGCTTAA TGATGGAAGA AATGTAGAAT TAGTCCAGAT ATCTGAAAAG 420 421 AACATCTCAC AGAAAGAGAA TATCCAAGGG CTTGTGTCAC ATTCACTTAT TTCCCCTCTA 480 481 AAGACCCCAG AAGCTGACAC TCCCTGTCCT CCCATTGTCC CTGTGATCCC TGTTATTCCA 540 541 GTCCCTGCTG AGAGCAATGT CATCCCATCC TCCACTCCAC AGGCAAATCC CCCACCGGTA 600 601 ATTGTTAACA CTGACCTGGA AACGCCAGCT TACGTTAATG GCACAGATGC TGAATATGAA 660 661 TACGAGGAAA TTACACTCGA AAGGGGCACT TCAGGACTTG GCTTTAGCAT TGCAGGTGGC 720 721 ACAGATAACC CACACATAGG AGATGATATA AGTATTTTTA TAACAAAAAT AATTTCTGGA 780 781 GGAGCAGCAG CACAAGATGG AAGATTACGG GTTAATGATT GCATATTACG GGTGAATGAA 840 841 GTGGACGTAC ATGATGTGAC ACACAGCAAA GCCGTTGAGG CGTTAAAAGA GGCAGGATCT 900 901 ATTGTCCGTC TGTACGTCAG AAGGAGAAAG CCTGTAACAG AGAAAATAAT GGACATAAAG 960 961 CTTGTTAAAG GCCCCAAAGG TCTTGGGTTC AGTATAGCTG GCGGTGTAGG AAATCAGCAC 1020 1021 ATACCTGGAG ATAACAGCAT TTACGTAACT AAAATCATTG AAGGTGGGGC AGCTCACAAA 1080 1081 GATGGAAGGC TTCAAATTGG GGACAAACTT CTAGCAGTGA ACACCGTGTG CCTGGAAGAA 1140 1141 GTAAGTCATG AAGATGCTGT GACTGCTTTG AAAAATACAT CAGATTTTGT TAATTTGAAA 1200 1201 GTGGCAAAAC CAACAACAAT GTACATGAAC GACAACTACG CTCCTCCAGA TATCACCAAC 1260 1261 TCATATTCTC AGCAAGTGGA TAACCATATC AGTCCATCAG GATTTATTGG GCATCCGCTG 1320 1321 CCGCCATCCC CTGGCCGATA CTCCCCAGCC CCAAAAGGAA TGCTGGAAGA TGATGATTTG 1380 1381 ACACGGGAAC CAAGGAAAGT TGTTTTACAG CGAGGTACAA CAGGACTTGG CTTCAACATT 1440 1441 GTTGGTGGTG AAGATGGAGA GGGTATTTTC ATATCCTTTA TACTCGCTGG AGGTCCGGCT 1500 1501 GATCTGAGTG GAGAACTCCA GAAAGGGGAT CGCATTATGT CTGTGAATGG AGTTGACCTA 1560 1561 AAATCTGCCA CTCATGAGCA GGCAGCAGCA GCCTTGAAGA ATGCTGGCCA GACAGTAACC 1620 1621 ATTGTTGCGC AATACCGTCC AGAAGAATAT AGTCGTTTTG AGGCCAAGAT TCATGACTTA 1680 1681 CGGGAGCAGA TGATGAATAG CAGCATTAGC TCTGGATCTG GTTCCCTGAG GACAAGCCAG 1740 1741 AAGCGATCAT TATATGTCAG GGCTCTTTTT GATTATGATA AGACAAAAGA CAGTGGCCTC 1800 1801 CCAAGCCAAG GACTTAATTT TAAATTTGGA GATATACTGC ACGTTGTTAA TGCCTCTGAT 1860 1861 GATGAATGGT GGCAAGCACG CCAAGTTACA GCAGATGGAG AAAGCGAGGA AATTGGAGTC 1920 1921 ATTCCAAGCA AGCGCAGAGT TGAAAAGAAA GAGCGTGCCA GGTTAAAGAC TGTCAAATTT 1980 1981 AATTCAAAAG CTAGAGGTGA CAAAGGGCAG TCATTCAATG ACAAGCGTAA AAAGAACCTC 2040 2041 TTTTCCCGAA AATTTCCATT CTACAAGAAC AAGGACCAGA GTGAAATGGA AACCAGTGAT 2100 2101 GTTGATCGTA AGGTATGCAG TAAAATGCCT TGCTACTCTG AGAGTTACAG TGGTCAAGAA 2160 2161 GAATATGTAT TATCATATGA GCCAGTCAAT CAACAAGAAG TAAACTACTC ACGACCAGTA 2220 2221 ATAATTTTGG GGCCTACGAA AGACAGAGTA AATGATGACC TGATCTCAGA ATTTCCAGAA 2280 2281 AAATTTGGAT CTTGTGTACC ACATACAACA AGACCTAAAA GAGACTATGA AATTGATGGC 2340 2341 AGAGATTACC ATTTTGTGAC TTCCCGAGAG CAGATGGAAA AGGATATACA GGATCACAGG 2400 2401 TTCATCGAAG CTGGACAGTA CAATAGCCAC CTCTATGGAA CAAGTGTCCA GTCTGTGAAA 2460 2461 GAAGTAGCAG AACGGGGCAA ACACTGCATT CTTGATGTAT CTGGCAATGC AATCAAAAGA 2520 2521 TTACAAATAG CACAACTCTA CCCAATTGCA ATCTTCATCA AGCCTAAATC TGTGGAAAAC 2580 2581 ATTATTGAAA TGAGCAAACG AGTGACAGAG GAACAAGGCC GCAAGACATA CGAGAGAGCT 2640 2641 ATGAAACTAG AGCAGGAATT CACAGAGCAT TTTACAGCAA TTGTGCAGGG AGACACTTTG 2700 2701 GAGGAAATCT ACAACCAGAT CAAACAGATC ATAGAAGAAC AATCCAGCAC CTTCATCTGG 2760 2761 GTTCCAGCTA AGGAGAAATT ATGA 2784 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Apical plasma membrane | |
Cellular Component | Basolateral plasma membrane | |
Cellular Component | Cell junction | |
Cellular Component | Endoplasmic reticulum membrane | |
Cellular Component | Neuromuscular junction | |
Cellular Component | Neuron projection | |
Cellular Component | Postsynaptic density membrane | |
Molecular Function | Ionotropic glutamate receptor binding | |
Biological Process | Cell-cell adhesion | |
Biological Process | Chemical synaptic transmission | |
Biological Process | Establishment or maintenance of epithelial cell apical/basal polarity | |
Biological Process | Receptor clustering | |
Biological Process | Receptor localization to synapse |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Aim-1025 | Ailuropoda melanoleuca | 87.53 | 0.0 | 1327 |
| LLPS-Lac-2034 | Latimeria chalumnae | 85.15 | 0.0 | 1586 |
| LLPS-Fia-2562 | Ficedula albicollis | 84.99 | 0.0 | 1550 |
| LLPS-Gaga-2049 | Gallus gallus | 84.93 | 0.0 | 1597 |
| LLPS-Gog-2015 | Gorilla gorilla | 84.38 | 0.0 | 1546 |
| LLPS-Hos-2514 | Homo sapiens | 84.38 | 0.0 | 1546 |
| LLPS-Cea-4643 | Cercocebus atys | 84.27 | 0.0 | 1538 |
| LLPS-Pat-4608 | Pan troglodytes | 84.27 | 0.0 | 1545 |
| LLPS-Pap-1693 | Pan paniscus | 84.27 | 0.0 | 1545 |
| LLPS-Mal-2319 | Mandrillus leucophaeus | 84.16 | 0.0 | 1541 |
| LLPS-Fud-3755 | Fukomys damarensis | 84.16 | 0.0 | 1550 |
| LLPS-Mam-2314 | Macaca mulatta | 84.16 | 0.0 | 1541 |
| LLPS-Otg-0963 | Otolemur garnettii | 84.16 | 0.0 | 1545 |
| LLPS-Caj-2727 | Callithrix jacchus | 84.05 | 0.0 | 1544 |
| LLPS-Rhb-1701 | Rhinopithecus bieti | 84.01 | 0.0 | 1419 |
| LLPS-Aon-2968 | Aotus nancymaae | 83.94 | 0.0 | 1541 |
| LLPS-Urm-1203 | Ursus maritimus | 83.94 | 0.0 | 1571 |
| LLPS-Chs-0826 | Chlorocebus sabaeus | 83.89 | 0.0 | 1241 |
| LLPS-Mup-1857 | Mustela putorius furo | 83.73 | 0.0 | 1566 |
| LLPS-Ova-0533 | Ovis aries | 83.73 | 0.0 | 1565 |
| LLPS-Pes-3702 | Pelodiscus sinensis | 83.71 | 0.0 | 1238 |
| LLPS-Myl-3853 | Myotis lucifugus | 83.51 | 0.0 | 1258 |
| LLPS-Sus-3831 | Sus scrofa | 83.51 | 0.0 | 1562 |
| LLPS-Fec-4707 | Felis catus | 83.32 | 0.0 | 1562 |
| LLPS-Paa-4045 | Papio anubis | 83.19 | 0.0 | 1533 |
| LLPS-Tut-1816 | Tursiops truncatus | 83.19 | 0.0 | 1545 |
| LLPS-Loa-1283 | Loxodonta africana | 83.19 | 0.0 | 1538 |
| LLPS-Maf-3168 | Macaca fascicularis | 83.09 | 0.0 | 1532 |
| LLPS-Man-3940 | Macaca nemestrina | 83.07 | 0.0 | 1530 |
| LLPS-Poa-0814 | Pongo abelii | 83.0 | 0.0 | 1475 |
| LLPS-Mum-3965 | Mus musculus | 82.97 | 0.0 | 1529 |
| LLPS-Orc-3064 | Oryctolagus cuniculus | 82.87 | 0.0 | 1540 |
| LLPS-Dio-2282 | Dipodomys ordii | 82.8 | 0.0 | 1238 |
| LLPS-Ict-0341 | Ictidomys tridecemlineatus | 82.77 | 0.0 | 1535 |
| LLPS-Nol-4038 | Nomascus leucogenys | 82.47 | 0.0 | 1494 |
| LLPS-Eqc-3443 | Equus caballus | 82.45 | 0.0 | 1546 |
| LLPS-Mea-2736 | Mesocricetus auratus | 82.33 | 0.0 | 1514 |
| LLPS-Anp-2930 | Anas platyrhynchos | 82.07 | 0.0 | 1484 |
| LLPS-Tag-1663 | Taeniopygia guttata | 81.69 | 0.0 | 1421 |
| LLPS-Ora-1685 | Ornithorhynchus anatinus | 81.63 | 0.0 | 1318 |
| LLPS-Cap-3115 | Cavia porcellus | 81.14 | 0.0 | 1474 |
| LLPS-Bot-0480 | Bos taurus | 80.17 | 0.0 | 1470 |
| LLPS-Ran-2162 | Rattus norvegicus | 79.4 | 0.0 | 1441 |
| LLPS-Mod-0349 | Monodelphis domestica | 78.8 | 0.0 | 1280 |
| LLPS-Asm-2416 | Astyanax mexicanus | 78.25 | 0.0 | 1451 |
| LLPS-Pof-1389 | Poecilia formosa | 78.17 | 0.0 | 1458 |
| LLPS-Orn-1929 | Oreochromis niloticus | 77.82 | 0.0 | 1310 |
| LLPS-Sah-3106 | Sarcophilus harrisii | 77.36 | 0.0 | 1325 |
| LLPS-Leo-2460 | Lepisosteus oculatus | 76.97 | 0.0 | 1442 |
| LLPS-Xim-3126 | Xiphophorus maculatus | 76.5 | 0.0 | 1449 |
| LLPS-Dar-1827 | Danio rerio | 76.24 | 0.0 | 1402 |
| LLPS-Scf-3800 | Scleropages formosus | 73.83 | 0.0 | 1275 |
| LLPS-Cas-2255 | Carlito syrichta | 72.05 | 0.0 | 1038 |
| LLPS-Orl-3301 | Oryzias latipes | 71.01 | 0.0 | 1056 |
| LLPS-Icp-3339 | Ictalurus punctatus | 70.82 | 0.0 | 1306 |
| LLPS-Scm-1016 | Scophthalmus maximus | 70.64 | 0.0 | 1060 |
| LLPS-Ere-0956 | Erinaceus europaeus | 70.53 | 0.0 | 1016 |
| LLPS-Anc-0216 | Anolis carolinensis | 69.95 | 0.0 | 1031 |
| LLPS-Gaa-2310 | Gasterosteus aculeatus | 69.65 | 0.0 | 1024 |
| LLPS-Ten-2406 | Tetraodon nigroviridis | 69.26 | 0.0 | 1020 |
| LLPS-Caf-3470 | Canis familiaris | 67.94 | 0.0 | 997 |
| LLPS-Meg-1551 | Meleagris gallopavo | 67.86 | 0.0 | 969 |
| LLPS-Tar-0408 | Takifugu rubripes | 61.52 | 0.0 | 1020 |
| LLPS-Drm-1967 | Drosophila melanogaster | 55.13 | 1e-15 | 85.9 |
| LLPS-Cae-1078 | Caenorhabditis elegans | 45.37 | 3e-167 | 521 |