• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Xet-3109
ube2m

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: NEDD8-conjugating enzyme Ubc12; NEDD8 carrier protein; Ubiquitin-conjugating enzyme E2 M
Gene Name: ube2m, ubc12
Ensembl Gene: ENSXETG00000018326.2
Ensembl Protein: ENSXETP00000039688.2
Organism: Xenopus tropicalis
Taxa ID: 8364
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granule, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase rbx1, but not rbx2, suggests that the rbx1-ube2m complex neddylates specific target proteins, such as cul1, cul2, cul3 and cul4. Involved in cell proliferation (By similarity).

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MIKLFSLKQQ  KKEEESAGGT  KGSSKKASAA  QLRIQKDINE  LNLPKTCEIE  FSDHDDLLNF  60
61    KLVICPDEGF  YKGGKFVFSF  KVGQGYPHDP  PKVKCETMVY  HPNIDLEGNV  CLNILREDWK  120
121   PVLTINSIIY  GLQYLFLEPN  PEDPLNKEAA  EVLQNNRRLF  EQNVQRSMRG  GYIGSTYFER  180
181   CLK  183
Nucleotide CDS Sequence (FASTA)
1     ATGATCAAAC  TCTTCTCCCT  CAAGCAGCAG  AAGAAGGAGG  AGGAATCTGC  AGGGGGAACT  60
61    AAAGGCAGCA  GTAAAAAGGC  CTCAGCCGCT  CAACTTCGCA  TTCAGAAAGA  TATTAACGAA  120
121   CTGAATTTGC  CGAAGACATG  TGAAATAGAG  TTCTCAGACC  ACGATGATCT  CTTAAATTTC  180
181   AAATTAGTCA  TCTGCCCTGA  TGAGGGTTTC  TACAAGGGTG  GAAAATTTGT  GTTCAGTTTT  240
241   AAGGTCGGAC  AGGGCTACCC  ACATGACCCT  CCAAAGGTGA  AATGTGAAAC  CATGGTATAT  300
301   CATCCAAATA  TAGACCTAGA  GGGCAATGTC  TGCTTAAATA  TTCTAAGAGA  GGACTGGAAG  360
361   CCTGTACTCA  CAATAAATTC  AATAATTTAT  GGCCTGCAGT  ATCTTTTCTT  GGAGCCAAAC  420
421   CCTGAAGACC  CATTAAATAA  AGAAGCTGCT  GAGGTTCTTC  AGAACAACAG  ACGCCTGTTT  480
481   GAACAGAATG  TGCAGCGATC  TATGCGGGGT  GGTTACATAG  GATCCACCTA  CTTTGAGCGC  540
541   TGCTTGAAAT  AG  552

▼ KEYWORD

ID
Family
Acetylation
ATP-binding
Complete proteome
Nucleotide-binding
Reference proteome
Transferase
Ubl conjugation pathway

▼ GENE ONTOLOGY

ID
Classification
Description
Molecular Function
ATP binding
Molecular Function
NEDD8 transferase activity
Molecular Function
Ubiquitin-protein transferase activity
Biological Process
Cellular protein modification process
Biological Process
Protein neddylation

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Nol-4459Nomascus leucogenys100.02e-57 181
LLPS-Anc-2872Anolis carolinensis98.913e-132 375
LLPS-Mam-3885Macaca mulatta98.725e-51 166
LLPS-Pes-1771Pelodiscus sinensis98.644e-105 305
LLPS-Gog-4819Gorilla gorilla97.813e-130 370
LLPS-Mea-1070Mesocricetus auratus97.813e-130 370
LLPS-Maf-4630Macaca fascicularis97.813e-130 370
LLPS-Mum-3910Mus musculus97.813e-130 370
LLPS-Chs-4654Chlorocebus sabaeus97.813e-130 370
LLPS-Cea-0159Cercocebus atys97.813e-130 370
LLPS-Aon-4470Aotus nancymaae97.813e-130 370
LLPS-Sus-2142Sus scrofa97.813e-130 370
LLPS-Ran-4097Rattus norvegicus97.813e-130 370
LLPS-Mal-1842Mandrillus leucophaeus97.813e-130 370
LLPS-Otg-1807Otolemur garnettii97.813e-130 370
LLPS-Orc-1815Oryctolagus cuniculus97.813e-130 370
LLPS-Rhb-3683Rhinopithecus bieti97.813e-130 370
LLPS-Pat-3820Pan troglodytes97.813e-130 370
LLPS-Hos-0752Homo sapiens97.813e-130 370
LLPS-Fec-4172Felis catus97.813e-130 370
LLPS-Man-4737Macaca nemestrina97.813e-130 370
LLPS-Ict-1754Ictidomys tridecemlineatus97.813e-130 370
LLPS-Poa-2085Pongo abelii97.813e-130 370
LLPS-Dio-3908Dipodomys ordii97.749e-126 358
LLPS-Pap-3866Pan paniscus97.749e-126 358
LLPS-Cas-3913Carlito syrichta97.674e-122 349
LLPS-Fud-2466Fukomys damarensis97.283e-103 300
LLPS-Aim-1690Ailuropoda melanoleuca97.283e-103 300
LLPS-Urm-3673Ursus maritimus97.286e-103 300
LLPS-Loa-1293Loxodonta africana97.284e-103 300
LLPS-Caf-2305Canis familiaris96.765e-128 365
LLPS-Tut-2205Tursiops truncatus96.275e-110 318
LLPS-Myl-1452Myotis lucifugus95.365e-104 303
LLPS-Gaga-0800Gallus gallus94.542e-128 365
LLPS-Cap-3950Cavia porcellus93.441e-121 348
LLPS-Meg-1034Meleagris gallopavo92.452e-68 211
LLPS-Asm-0960Astyanax mexicanus91.351e-121 348
LLPS-Icp-4160Ictalurus punctatus91.359e-122 349
LLPS-Caj-3485Callithrix jacchus91.358e-119 341
LLPS-Eqc-1480Equus caballus91.354e-118 340
LLPS-Dar-3834Danio rerio90.811e-117 338
LLPS-Sah-3964Sarcophilus harrisii90.86e-106 308
LLPS-Ova-3139Ovis aries90.542e-93 275
LLPS-Fia-3344Ficedula albicollis90.363e-50 163
LLPS-Orn-2520Oreochromis niloticus90.271e-120 346
LLPS-Orl-1938Oryzias latipes89.732e-116 335
LLPS-Pof-2258Poecilia formosa88.779e-115 331
LLPS-Scf-2636Scleropages formosus88.643e-113 328
LLPS-Paa-0934Papio anubis84.73e-103 301
LLPS-Xim-1563Xiphophorus maculatus82.167e-102 298
LLPS-Ten-1346Tetraodon nigroviridis78.381e-98 290
LLPS-Bot-3805Bos taurus76.881e-95 285
LLPS-Lac-2736Latimeria chalumnae76.225e-75 231
LLPS-Cii-0096Ciona intestinalis75.414e-101 296
LLPS-Drm-0617Drosophila melanogaster74.731e-97 288
LLPS-Php-0724Physcomitrella patens68.314e-87 261
LLPS-Vir-1897Vigna radiata65.335e-69 214
LLPS-Sem-1475Selaginella moellendorffii65.229e-84 252
LLPS-Sob-1883Sorghum bicolor64.842e-85 256
LLPS-Zem-1633Zea mays64.841e-84 255
LLPS-Sei-1724Setaria italica64.293e-84 253
LLPS-Sol-2008Solanum lycopersicum63.397e-82 247
LLPS-Cus-0714Cucumis sativus63.393e-82 248
LLPS-Coc-2233Corchorus capsularis63.391e-82 249
LLPS-Thc-1316Theobroma cacao62.843e-81 246
LLPS-Mua-1900Musa acuminata62.841e-82 251
LLPS-Sot-1898Solanum tuberosum62.842e-82 249
LLPS-Nia-2211Nicotiana attenuata62.842e-82 249
LLPS-Spr-0713Sporisorium reilianum62.823e-70 218
LLPS-Usm-1208Ustilago maydis62.668e-70 216
LLPS-Brd-0229Brachypodium distachyon62.641e-81 247
LLPS-Abg-1079Absidia glauca62.53e-49 162
LLPS-Dac-1777Daucus carota62.31e-81 247
LLPS-Viv-0415Vitis vinifera62.31e-79 243
LLPS-Mae-2215Manihot esculenta62.161e-79 242
LLPS-Gor-2528Gossypium raimondii62.162e-79 241
LLPS-Cis-0659Ciona savignyi62.045e-91 272
LLPS-Pytr-0875Pyrenophora triticirepentis61.95e-63 198
LLPS-Orp-1838Oryza punctata61.855e-77 234
LLPS-Asni-0055Aspergillus niger61.763e-59 188
LLPS-Pot-1211Populus trichocarpa61.756e-80 243
LLPS-Orni-0672Oryza nivara61.541e-81 247
LLPS-Orb-2249Oryza barthii61.541e-81 247
LLPS-Orgl-2404Oryza glumaepatula61.541e-81 247
LLPS-Ors-1140Oryza sativa61.548e-82 247
LLPS-Org-0836Oryza glaberrima61.541e-81 247
LLPS-Orr-1757Oryza rufipogon61.541e-81 247
LLPS-Orm-1770Oryza meridionalis61.542e-81 248
LLPS-Brn-3009Brassica napus61.417e-79 241
LLPS-Put-1166Puccinia triticina61.244e-72 223
LLPS-Hea-0966Helianthus annuus61.23e-80 245
LLPS-Ori-1604Oryza indica61.22e-78 246
LLPS-Via-0177Vigna angularis61.26e-80 242
LLPS-Glm-1465Glycine max61.081e-78 239
LLPS-Arl-0496Arabidopsis lyrata61.083e-79 241
LLPS-Art-2241Arabidopsis thaliana61.083e-78 238
LLPS-Lep-2365Leersia perrieri61.022e-76 234
LLPS-Crn-1458Cryptococcus neoformans60.998e-75 229
LLPS-Hov-2222Hordeum vulgare60.995e-76 233
LLPS-Tra-1943Triticum aestivum60.997e-76 232
LLPS-Orbr-0248Oryza brachyantha60.997e-81 246
LLPS-Miv-1442Microbotryum violaceum60.892e-77 236
LLPS-Phv-1956Phaseolus vulgaris60.664e-79 240
LLPS-Prp-0822Prunus persica60.668e-80 242
LLPS-Tru-1046Triticum urartu60.444e-75 230
LLPS-Gas-1378Galdieria sulphuraria60.349e-72 221
LLPS-Map-0089Magnaporthe poae60.331e-77 236
LLPS-Bro-1836Brassica oleracea60.226e-79 240
LLPS-Met-0847Medicago truncatula60.111e-79 242
LLPS-Amt-0946Amborella trichopoda60.112e-79 241
LLPS-Brr-2761Brassica rapa60.01e-78 239
LLPS-Pug-1482Puccinia graminis59.788e-70 219
LLPS-Asn-1169Aspergillus nidulans59.244e-70 217
LLPS-Mao-1348Magnaporthe oryzae59.241e-77 237
LLPS-Gag-0722Gaeumannomyces graminis59.244e-77 235
LLPS-Mel-1498Melampsora laricipopulina59.023e-72 223
LLPS-Chr-0461Chlamydomonas reinhardtii59.024e-73 225
LLPS-Asf-1087Aspergillus flavus58.78e-69 214
LLPS-Aso-1506Aspergillus oryzae58.78e-69 214
LLPS-Ast-1327Aspergillus terreus58.648e-64 202
LLPS-Tum-0935Tuber melanosporum58.473e-71 220
LLPS-Fuv-1289Fusarium verticillioides58.383e-77 236
LLPS-Osl-1090Ostreococcus lucimarinus58.382e-74 229
LLPS-Fuo-1494Fusarium oxysporum58.383e-77 236
LLPS-Lem-1577Leptosphaeria maculans57.929e-77 234
LLPS-Pyt-1275Pyrenophora teres57.923e-73 226
LLPS-Fus-0991Fusarium solani57.842e-76 234
LLPS-Beb-1521Beauveria bassiana57.383e-76 233
LLPS-Ved-0116Verticillium dahliae57.33e-71 220
LLPS-Asc-0805Aspergillus clavatus57.071e-66 209
LLPS-Nef-1296Neosartorya fischeri57.076e-67 209
LLPS-Asfu-0793Aspergillus fumigatus57.076e-67 209
LLPS-Scs-0075Sclerotinia sclerotiorum56.835e-72 223
LLPS-Dos-1193Dothistroma septosporum56.832e-75 231
LLPS-Scc-1233Schizosaccharomyces cryophilus56.773e-59 189
LLPS-Nec-0683Neurospora crassa56.769e-75 229
LLPS-Blg-0013Blumeria graminis56.524e-73 225
LLPS-Coo-0079Colletotrichum orbiculare56.282e-75 231
LLPS-Zyt-1476Zymoseptoria tritici56.281e-75 231
LLPS-Trr-1121Trichoderma reesei56.225e-74 227
LLPS-Trv-1397Trichoderma virens56.225e-73 225
LLPS-Yal-1421Yarrowia lipolytica56.044e-71 220
LLPS-Phn-1490Phaeosphaeria nodorum56.025e-68 212
LLPS-Cog-0641Colletotrichum gloeosporioides55.747e-75 229
LLPS-Cogr-0673Colletotrichum graminicola55.193e-74 228
LLPS-Chc-0958Chondrus crispus54.861e-71 221
LLPS-Scj-1580Schizosaccharomyces japonicus51.651e-61 196
LLPS-Scp-0705Schizosaccharomyces pombe49.733e-58 187
LLPS-Kop-0258Komagataella pastoris49.723e-58 187
LLPS-Asg-0709Ashbya gossypii42.224e-40 141
LLPS-Cym-1016Cyanidioschyzon merolae41.678e-36 130
LLPS-Sac-1511Saccharomyces cerevisiae41.273e-45 154
LLPS-Cae-0323Caenorhabditis elegans38.354e-25 100
LLPS-Leo-3082Lepisosteus oculatus36.094e-2498.2
LLPS-Mod-2085Monodelphis domestica36.094e-2498.2