• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Xet-1507
cnot9

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: CCR4-NOT transcription complex subunit 9; Cell differentiation protein RQCD1 homolog; Rcd-1
Gene Name: cnot9, rcd1, rqcd1, TNeu111l17.1
Ensembl Gene: ENSXETG00000014984.3
Ensembl Protein: ENSXETP00000032762.3
Organism: Xenopus tropicalis
Taxa ID: 8364
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
P-body, Stress granulePredicted from orthologs(View)

▼ FUNCTION

Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors. May play a role in cell differentiation.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MHSLATAAPV  PAALAQVDRE  KIYQWINELS  SPDTRENALL  ELSKKRESVP  DLAPMLWHSF  60
61    GTIAALLQEI  VNIYPSINPP  TLTAHQSNRV  CNALALLQCV  ASHPETRSAF  LAAHIPLFLY  120
121   PFLHTVSKTR  PFEYLRLTSL  GVIGALVKTD  EQEVINFLLT  TEIIPLCLRI  MESGSELSKT  180
181   VATFILQKIL  LDDTGLAYIC  QTYERFSHVA  MILGKMVLQL  SKEPSARLLK  HVVRCYLRLS  240
241   DNPRAREALR  QCLPDQLKDT  TFAQVLKDDT  TTKRWLAQLV  KNLQEGQVTD  PRGIPLPPQ  299
Nucleotide CDS Sequence (FASTA)
1     ATGCACAGCC  TGGCCACGGC  GGCGCCTGTG  CCGGCAGCTC  TTGCTCAGGT  GGATCGAGAG  60
61    AAAATCTATC  AGTGGATTAA  TGAGTTGTCC  AGCCCTGATA  CCCGCGAGAA  TGCCTTGCTC  120
121   GAGCTCAGCA  AAAAGCGTGA  ATCCGTTCCA  GACCTTGCTC  CTATGCTGTG  GCACTCCTTC  180
181   GGCACAATAG  CAGCACTTCT  ACAGGAAATT  GTGAATATCT  ATCCCTCAAT  AAATCCACCA  240
241   ACTTTGACCG  CACATCAGTC  TAACAGAGTC  TGCAATGCTT  TGGCACTGCT  TCAGTGTGTG  300
301   GCATCGCACC  CAGAAACCAG  ATCTGCATTT  CTTGCTGCCC  ATATTCCTCT  GTTCCTGTAT  360
361   CCTTTCTTAC  ACACTGTCAG  TAAGACTCGA  CCCTTTGAGT  ACCTGCGGCT  CACCAGCCTA  420
421   GGAGTCATTG  GTGCCCTTGT  GAAAACGGAC  GAACAAGAAG  TCATAAACTT  CCTCCTTACC  480
481   ACAGAAATAA  TCCCATTGTG  CCTACGTATT  ATGGAGTCTG  GAAGTGAACT  CTCCAAAACA  540
541   GTTGCCACTT  TTATTCTTCA  GAAGATTCTC  CTAGATGATA  CGGGTTTGGC  CTATATTTGC  600
601   CAAACTTATG  AGCGCTTCTC  TCATGTTGCA  ATGATTTTGG  GGAAAATGGT  CCTACAGCTT  660
661   TCAAAGGAGC  CATCTGCAAG  GTTGCTGAAA  CATGTAGTAC  GCTGTTACCT  CCGCCTCTCA  720
721   GACAATCCAA  GAGCGAGAGA  GGCATTGAGG  CAGTGTTTGC  CCGACCAGCT  AAAGGATACC  780
781   ACTTTTGCAC  AGGTACTTAA  GGATGATACC  ACAACCAAGC  GCTGGCTGGC  TCAGCTTGTC  840
841   AAGAACCTGC  AAGAAGGTCA  GGTCACTGAC  CCTAGAGGAA  TACCCCTGCC  TCCCCAGTAA  900

▼ KEYWORD

ID
Family
Activator
Complete proteome
Cytoplasm
Nucleus
Reference proteome
Repressor
RNA-mediated gene silencing
Transcription
Transcription regulation
Translation regulation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
CCR4-NOT complex
Cellular Component
CCR4-NOT core complex
Cellular Component
Nucleus
Cellular Component
P-body
Biological Process
Gene silencing by RNA
Biological Process
MRNA catabolic process
Biological Process
Negative regulation of intracellular estrogen receptor signaling pathway
Biological Process
Negative regulation of translation
Biological Process
Positive regulation of nuclear receptor transcription coactivator activity

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Fia-0962Ficedula albicollis100.03e-180 504
LLPS-Sus-2592Sus scrofa99.650.0 579
LLPS-Sah-1983Sarcophilus harrisii99.650.0 580
LLPS-Tag-0774Taeniopygia guttata99.650.0 582
LLPS-Otg-2642Otolemur garnettii99.650.0 581
LLPS-Anp-0477Anas platyrhynchos99.650.0 582
LLPS-Meg-1526Meleagris gallopavo99.650.0 582
LLPS-Mup-2107Mustela putorius furo99.330.0 586
LLPS-Aim-1043Ailuropoda melanoleuca99.330.0 586
LLPS-Myl-1983Myotis lucifugus99.330.0 586
LLPS-Ova-2413Ovis aries99.330.0 586
LLPS-Ran-2753Rattus norvegicus99.330.0 586
LLPS-Dio-1001Dipodomys ordii99.330.0 586
LLPS-Bot-2794Bos taurus99.330.0 586
LLPS-Fud-0083Fukomys damarensis99.330.0 586
LLPS-Mum-3692Mus musculus99.330.0 586
LLPS-Chs-1823Chlorocebus sabaeus99.330.0 586
LLPS-Ict-3361Ictidomys tridecemlineatus99.330.0 586
LLPS-Gaga-2261Gallus gallus99.330.0 586
LLPS-Cas-1801Carlito syrichta99.330.0 586
LLPS-Cap-2150Cavia porcellus99.330.0 586
LLPS-Urm-2601Ursus maritimus99.330.0 586
LLPS-Fec-0313Felis catus99.330.0 586
LLPS-Mod-1848Monodelphis domestica99.330.0 586
LLPS-Scf-0476Scleropages formosus99.30.0 582
LLPS-Pes-0506Pelodiscus sinensis99.181e-177 500
LLPS-Mea-1683Mesocricetus auratus99.00.0 586
LLPS-Anc-1756Anolis carolinensis99.00.0 586
LLPS-Poa-1148Pongo abelii99.00.0 586
LLPS-Orc-0663Oryctolagus cuniculus98.950.0 576
LLPS-Loa-2663Loxodonta africana98.950.0 576
LLPS-Tar-0124Takifugu rubripes98.940.0 577
LLPS-Ten-2054Tetraodon nigroviridis98.940.0 577
LLPS-Lac-0131Latimeria chalumnae98.330.0 584
LLPS-Ere-0725Erinaceus europaeus98.254e-160 453
LLPS-Xim-2047Xiphophorus maculatus98.240.0 574
LLPS-Leo-0927Lepisosteus oculatus98.240.0 568
LLPS-Pof-1128Poecilia formosa98.240.0 574
LLPS-Gaa-2296Gasterosteus aculeatus97.890.0 571
LLPS-Asm-1417Astyanax mexicanus97.890.0 570
LLPS-Orl-3760Oryzias latipes97.890.0 570
LLPS-Orn-2328Oreochromis niloticus97.890.0 571
LLPS-Scm-1647Scophthalmus maximus97.890.0 570
LLPS-Ora-2812Ornithorhynchus anatinus97.88e-114 337
LLPS-Dar-0417Danio rerio97.540.0 568
LLPS-Caf-2382Canis familiaris97.320.0 583
LLPS-Icp-1919Ictalurus punctatus96.830.0 565
LLPS-Eqc-1872Equus caballus96.210.0 544
LLPS-Cis-1362Ciona savignyi94.424e-146 417
LLPS-Mam-3186Macaca mulatta93.890.0 569
LLPS-Cii-0063Ciona intestinalis91.460.0 523
LLPS-Maf-1430Macaca fascicularis90.270.0 571
LLPS-Caj-0108Callithrix jacchus90.00.0 571
LLPS-Aon-1516Aotus nancymaae90.00.0 572
LLPS-Rhb-2416Rhinopithecus bieti89.60.0 562
LLPS-Gog-2351Gorilla gorilla89.430.0 570
LLPS-Nol-1926Nomascus leucogenys89.430.0 570
LLPS-Hos-1222Homo sapiens89.430.0 570
LLPS-Pat-2342Pan troglodytes89.430.0 570
LLPS-Pap-1203Pan paniscus89.430.0 570
LLPS-Cea-0533Cercocebus atys88.750.0 564
LLPS-Paa-0145Papio anubis88.220.0 563
LLPS-Mal-1361Mandrillus leucophaeus86.965e-176 494
LLPS-Man-1638Macaca nemestrina86.390.0 560
LLPS-Gas-0817Galdieria sulphuraria80.02e-106 316
LLPS-Drm-1139Drosophila melanogaster79.02e-160 456
LLPS-Amt-0355Amborella trichopoda74.99e-140 404
LLPS-Sei-0927Setaria italica73.851e-135 394
LLPS-Spr-0551Sporisorium reilianum73.812e-127 377
LLPS-Usm-0701Ustilago maydis73.814e-127 376
LLPS-Hea-1069Helianthus annuus73.583e-139 402
LLPS-Sob-0637Sorghum bicolor73.463e-135 393
LLPS-Gor-1933Gossypium raimondii73.185e-137 398
LLPS-Pot-1160Populus trichocarpa72.94e-137 398
LLPS-Osl-1048Ostreococcus lucimarinus72.873e-136 394
LLPS-Coc-0853Corchorus capsularis72.81e-136 396
LLPS-Mae-1390Manihot esculenta72.83e-136 395
LLPS-Phn-0497Phaeosphaeria nodorum72.762e-139 405
LLPS-Abg-0306Absidia glauca72.692e-137 399
LLPS-Orm-0553Oryza meridionalis72.696e-134 390
LLPS-Tum-1485Tuber melanosporum72.454e-134 391
LLPS-Glm-0923Glycine max72.458e-137 397
LLPS-Phv-0123Phaseolus vulgaris72.453e-137 398
LLPS-Php-2309Physcomitrella patens72.432e-140 405
LLPS-Mel-0221Melampsora laricipopulina72.351e-131 382
LLPS-Tra-2134Triticum aestivum72.312e-132 386
LLPS-Orgl-1128Oryza glumaepatula72.319e-133 387
LLPS-Orb-0043Oryza barthii72.319e-133 387
LLPS-Ori-0457Oryza indica72.319e-133 387
LLPS-Orr-0304Oryza rufipogon72.319e-133 387
LLPS-Ors-1309Oryza sativa72.319e-133 387
LLPS-Pyt-1133Pyrenophora teres72.264e-140 407
LLPS-Lem-1416Leptosphaeria maculans72.262e-137 405
LLPS-Pytr-0877Pyrenophora triticirepentis72.265e-141 408
LLPS-Coo-1094Colletotrichum orbiculare71.976e-135 390
LLPS-Miv-0206Microbotryum violaceum71.965e-133 394
LLPS-Pug-0032Puccinia graminis71.966e-131 385
LLPS-Hov-0464Hordeum vulgare71.928e-131 384
LLPS-Cym-0294Cyanidioschyzon merolae71.865e-137 396
LLPS-Cus-0335Cucumis sativus71.72e-135 394
LLPS-Prp-0130Prunus persica71.72e-134 390
LLPS-Orp-1347Oryza punctata71.73e-134 391
LLPS-Nia-1283Nicotiana attenuata71.536e-139 402
LLPS-Cog-0730Colletotrichum gloeosporioides71.492e-109 327
LLPS-Thc-0175Theobroma cacao71.377e-133 387
LLPS-Nec-0160Neurospora crassa71.225e-136 396
LLPS-Met-2010Medicago truncatula71.111e-137 399
LLPS-Mao-0813Magnaporthe oryzae70.99e-134 391
LLPS-Trv-1018Trichoderma virens70.87e-135 394
LLPS-Scp-0329Schizosaccharomyces pombe70.638e-136 393
LLPS-Sem-0595Selaginella moellendorffii70.59e-138 399
LLPS-Blg-0172Blumeria graminis70.486e-134 391
LLPS-Ved-1072Verticillium dahliae70.482e-134 392
LLPS-Fuv-0895Fusarium verticillioides70.443e-134 392
LLPS-Fuo-0014Fusarium oxysporum70.443e-134 392
LLPS-Fus-1064Fusarium solani70.449e-134 391
LLPS-Scc-1362Schizosaccharomyces cryophilus70.372e-135 392
LLPS-Trr-0931Trichoderma reesei70.292e-135 395
LLPS-Beb-0495Beauveria bassiana70.267e-133 390
LLPS-Tru-0328Triticum urartu70.02e-125 367
LLPS-Cogr-1034Colletotrichum graminicola69.937e-135 394
LLPS-Scj-0159Schizosaccharomyces japonicus69.891e-134 390
LLPS-Zem-1046Zea mays69.892e-134 391
LLPS-Chr-0601Chlamydomonas reinhardtii69.752e-140 405
LLPS-Zyt-1495Zymoseptoria tritici69.712e-133 391
LLPS-Lep-0026Leersia perrieri69.711e-133 389
LLPS-Crn-0235Cryptococcus neoformans69.716e-128 379
LLPS-Orbr-0977Oryza brachyantha69.712e-134 391
LLPS-Arl-2444Arabidopsis lyrata69.635e-132 385
LLPS-Gag-0453Gaeumannomyces graminis69.572e-133 390
LLPS-Mua-2107Musa acuminata69.553e-132 386
LLPS-Dos-0227Dothistroma septosporum69.533e-135 396
LLPS-Map-0385Magnaporthe poae69.319e-136 393
LLPS-Brn-2914Brassica napus69.263e-131 383
LLPS-Bro-2075Brassica oleracea69.267e-131 383
LLPS-Brr-2385Brassica rapa69.262e-131 384
LLPS-Art-2846Arabidopsis thaliana69.261e-131 384
LLPS-Asfu-0983Aspergillus fumigatus69.186e-138 403
LLPS-Orni-0610Oryza nivara69.01e-128 377
LLPS-Org-0383Oryza glaberrima69.01e-128 377
LLPS-Asf-1237Aspergillus flavus68.829e-137 400
LLPS-Aso-0248Aspergillus oryzae68.824e-139 402
LLPS-Asni-0571Aspergillus niger68.828e-139 401
LLPS-Asc-1050Aspergillus clavatus68.827e-137 400
LLPS-Nef-0971Neosartorya fischeri68.823e-137 401
LLPS-Ast-0517Aspergillus terreus68.825e-137 400
LLPS-Asn-0062Aspergillus nidulans68.467e-138 403
LLPS-Cae-1243Caenorhabditis elegans68.155e-136 395
LLPS-Brd-0735Brachypodium distachyon68.121e-129 379
LLPS-Yal-0416Yarrowia lipolytica68.039e-132 383
LLPS-Kop-1114Komagataella pastoris67.665e-128 376
LLPS-Chc-1028Chondrus crispus67.263e-134 389
LLPS-Viv-2010Vitis vinifera66.781e-128 378
LLPS-Asg-0912Ashbya gossypii65.561e-117 350
LLPS-Vir-2017Vigna radiata63.025e-111 332
LLPS-Sac-0325Saccharomyces cerevisiae61.481e-111 335
LLPS-Via-0060Vigna angularis60.279e-25 100
LLPS-Dac-0419Daucus carota57.01e-108 325
LLPS-Put-0372Puccinia triticina55.962e-62 209
LLPS-Sol-2168Solanum lycopersicum45.967e-69 222
LLPS-Sot-1787Solanum tuberosum40.917e-60 198