• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Vir-0821
LOC106762134

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: DNA topoisomerase 2
Gene Name: LOC106762134
Ensembl Gene: vigra.VC1973A.gnm6.ann1.Vradi05g17120
Ensembl Protein: vigra.VC1973A.gnm6.ann1.Vradi05g17120.1
Organism: Vigna radiata
Taxa ID: 3916
LLPS Type: Others


▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Centrosome/Spindle pole body, P-body, OthersPredicted from orthologs(View)

▼ FUNCTION

Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MEPQTKRPLQ  SSSAANVAAA  AGKTIEEVYQ  KKTQLEHILL  RPDTYVGSIE  KHTQTLWVYQ  60
61    NGEMVQRPVS  YVPGLYKIFD  EILVNAADNK  QRDPSMDALK  VTIDAEQNTV  SVYNNGDGVP  120
121   VEIHQEEKVY  VPELIFGHLL  TSSNYDDNVK  KTTGGRNGYG  AKLTNIFSTE  FVIETADGKR  180
181   QKKYKQVFSN  NMGKKSEPVI  TKCKGGENWT  KVTFKPDLAK  FKMDHLEEDV  VALMKKRVVD  240
241   MAGCLGKTVK  VELNGQVIRM  KSFRDYADLY  LKSAEKSKPV  PLPRIHAKVG  ERWEICVSLS  300
301   DGQFQQVSFV  NSIATIKGGT  HVDYVTNQIT  NFVMAKVNKK  KKDASVKAHN  VKNHLWVFVN  360
361   ALIDNPAFDS  QTKETLTTRQ  ASFGSKCDVP  DSMLKEVANS  GIVDTLLSWA  DFKQSKDLKK  420
421   TDGTKTQRLR  GIVKLEDAND  AGSRNSEKCT  LILTEGDSAK  ALAMAGLSVV  GRDHYGVFPL  480
481   RGKLLNVREA  SSKQIMDNEE  IQNIKKILGL  QQNKEYTNVK  SLRYGHLMIM  ADQDHDGSHI  540
541   KGLLINFIHS  FWPSLLKVPT  FMVEFTTPII  RAFHSNGTKL  SFYSMPEYES  WRERLGNASG  600
601   WKIKYYKGLG  TSTPQEGREY  FGDLGKHKKD  FVWDDEQDGS  AIEMAFSKKK  AEDRKTWIRN  660
661   FEPGTYRDHS  ARYINYRDFV  NKELILFSRA  DLQRSIPSMV  DGLKPGQRKI  LFCSFKKKLF  720
721   KEIKVAQFIG  YVSEHSAYHH  GEQSLSSTII  NMAQDFVGSN  NINLLKPNGQ  FGTRNLGGKD  780
781   HASARYIYTE  LNNITRCIFH  EDDDKLLEYL  SEDGKSIEPN  WYMPVIPLVL  VNGSEGIGTG  840
841   WSSFIPNYNP  REIIANIRRL  LSGEALVPMN  PWYKGFKGTI  ERSPKEGGYV  VNGLAEEIDE  900
901   QTFRISELPV  RKWTQDYKQF  LESITDGSPN  VKDPLIDDFR  QNGDDAIVDI  EVRMKLDKIA  960
961   GIMQEGLLKK  FKLTTSLSTN  NMHLFDAEGK  IKKYDSPEEI  LEEFFPLRLD  YYERRKNHIL  1020
1021  NNLERLLLVL  DNKVRFILGV  VSGEIIVNNR  KNADLVIELQ  QKGFTPMPRK  GKSAEPVVAG  1080
1081  ANDEEEQEDD  NSTEQETGSV  EAAKRGDYEY  LLAMSIRTLT  FESVQKLLAE  KAEKEKEFEI  1140
1141  LKATPSKSMW  LKDLDELEKK  LDEIDSKEAE  EELKRSSQAT  RKASNRGVSA  ATKAAKKPPP  1200
1201  QPRKYTKKAK  NVEPDNDNSS  MEVENVAEVT  KPKGRAAGSE  NTQTVGDDEI  ASLQERLAAY  1260
1261  NFAPSSDQST  GISPEKKVRK  MRASPFNKKS  SSVLGRVAAA  ANIEESVSED  LSGGGSAGSN  1320
1321  PSPGTAEDEV  VEVAAPPSRT  RPQRVIRKPM  TFEPKTLFKT  IMLTTTRGDQ  QGCLVDINHQ  1380

▼ KEYWORD

ID
Family
ATP-binding
Coiled coil
Complete proteome
DNA-binding
Isomerase
Nucleotide-binding
Reference proteome
Topoisomerase

▼ GENE ONTOLOGY

ID
Classification
Description
Molecular Function
ATP binding
Molecular Function
DNA binding
Molecular Function
DNA topoisomerase type II (ATP-hydrolyzing) activity
Biological Process
DNA topological change

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Via-0487Vigna angularis96.00.02353
LLPS-Phv-0522Phaseolus vulgaris92.140.02284
LLPS-Glm-0228Glycine max89.450.02199
LLPS-Met-1652Medicago truncatula80.120.01993
LLPS-Ors-1369Oryza sativa75.050.01416
LLPS-Amt-0477Amborella trichopoda73.560.01652
LLPS-Mua-1114Musa acuminata71.230.01610
LLPS-Viv-0295Vitis vinifera70.80.01753
LLPS-Cus-0911Cucumis sativus70.510.01593
LLPS-Php-0631Physcomitrella patens70.190.01561
LLPS-Sem-0817Selaginella moellendorffii69.40.01571
LLPS-Zem-0734Zea mays69.160.01557
LLPS-Orbr-0422Oryza brachyantha68.880.01550
LLPS-Tra-2793Triticum aestivum68.840.01554
LLPS-Pot-2482Populus trichocarpa68.470.01632
LLPS-Prp-0453Prunus persica68.340.01693
LLPS-Dac-0114Daucus carota67.910.01513
LLPS-Thc-0408Theobroma cacao67.650.01686
LLPS-Brd-0730Brachypodium distachyon67.470.01542
LLPS-Gor-0220Gossypium raimondii67.440.01658
LLPS-Sot-0381Solanum tuberosum66.690.01614
LLPS-Sol-0845Solanum lycopersicum66.670.01604
LLPS-Nia-0916Nicotiana attenuata66.030.01613
LLPS-Arl-0792Arabidopsis lyrata65.990.01563
LLPS-Tag-3497Taeniopygia guttata65.936e-52 185
LLPS-Mae-0390Manihot esculenta65.060.01583
LLPS-Sob-0618Sorghum bicolor64.820.01533
LLPS-Orr-0154Oryza rufipogon64.10.01566
LLPS-Org-0004Oryza glaberrima64.10.01565
LLPS-Orb-1243Oryza barthii64.10.01565
LLPS-Orni-0744Oryza nivara64.10.01565
LLPS-Orgl-1604Oryza glumaepatula64.030.01564
LLPS-Lep-0292Leersia perrieri63.670.01560
LLPS-Hov-0717Hordeum vulgare63.660.01543
LLPS-Coc-0337Corchorus capsularis63.40.01564
LLPS-Sei-0191Setaria italica63.020.01530
LLPS-Brn-3368Brassica napus62.670.01648
LLPS-Orm-1022Oryza meridionalis62.660.01568
LLPS-Hea-0320Helianthus annuus62.530.01522
LLPS-Brr-1058Brassica rapa62.430.01631
LLPS-Tru-0090Triticum urartu61.70.01556
LLPS-Orp-0191Oryza punctata61.70.01560
LLPS-Ori-0436Oryza indica61.660.01471
LLPS-Bro-0129Brassica oleracea61.510.01641
LLPS-Art-0275Arabidopsis thaliana59.780.01573
LLPS-Chr-0253Chlamydomonas reinhardtii58.780.01308
LLPS-Mea-1282Mesocricetus auratus58.530.0 595
LLPS-Pug-0864Puccinia graminis57.140.0 615
LLPS-Osl-1016Ostreococcus lucimarinus57.090.01273
LLPS-Mup-2930Mustela putorius furo56.110.01063
LLPS-Crn-0113Cryptococcus neoformans56.00.01230
LLPS-Put-0018Puccinia triticina55.160.01210
LLPS-Gas-0316Galdieria sulphuraria54.820.01174
LLPS-Aim-1927Ailuropoda melanoleuca54.770.01119
LLPS-Caf-1226Canis familiaris54.590.01115
LLPS-Fec-2597Felis catus54.590.01115
LLPS-Urm-1114Ursus maritimus54.490.01115
LLPS-Paa-1409Papio anubis54.310.01105
LLPS-Ran-3717Rattus norvegicus54.170.01111
LLPS-Mel-0086Melampsora laricipopulina54.120.01180
LLPS-Mod-0655Monodelphis domestica54.020.01134
LLPS-Gaga-0887Gallus gallus53.840.01119
LLPS-Sah-1046Sarcophilus harrisii53.840.01132
LLPS-Fud-3420Fukomys damarensis53.840.01126
LLPS-Fia-2030Ficedula albicollis53.80.01124
LLPS-Eqc-0483Equus caballus53.750.01122
LLPS-Cas-1774Carlito syrichta53.750.01122
LLPS-Orc-0214Oryctolagus cuniculus53.750.01129
LLPS-Myl-1098Myotis lucifugus53.710.01125
LLPS-Ict-2214Ictidomys tridecemlineatus53.660.01121
LLPS-Aon-1596Aotus nancymaae53.660.01124
LLPS-Chs-1762Chlorocebus sabaeus53.660.01126
LLPS-Mum-0235Mus musculus53.660.01123
LLPS-Meg-0301Meleagris gallopavo53.650.01106
LLPS-Mam-3040Macaca mulatta53.570.01106
LLPS-Man-2748Macaca nemestrina53.570.01106
LLPS-Hos-0076Homo sapiens53.570.01122
LLPS-Pap-1186Pan paniscus53.570.01123
LLPS-Bot-1132Bos taurus53.570.01127
LLPS-Maf-2097Macaca fascicularis53.570.01106
LLPS-Caj-0232Callithrix jacchus53.570.01121
LLPS-Gog-0011Gorilla gorilla53.570.01122
LLPS-Anp-0105Anas platyrhynchos53.510.01118
LLPS-Pat-1204Pan troglodytes53.480.01121
LLPS-Ova-3316Ovis aries53.480.01126
LLPS-Mal-1417Mandrillus leucophaeus53.480.01105
LLPS-Loa-1192Loxodonta africana53.440.01124
LLPS-Cap-3925Cavia porcellus53.370.01123
LLPS-Miv-0592Microbotryum violaceum53.370.01182
LLPS-Tut-0328Tursiops truncatus53.340.01120
LLPS-Otg-4464Otolemur garnettii53.30.01112
LLPS-Poa-0911Pongo abelii53.290.01125
LLPS-Dio-1077Dipodomys ordii53.250.01117
LLPS-Sus-2527Sus scrofa53.250.01115
LLPS-Cea-0600Cercocebus atys53.250.01124
LLPS-Ora-1514Ornithorhynchus anatinus53.250.01129
LLPS-Nol-0915Nomascus leucogenys53.20.01125
LLPS-Scp-0780Schizosaccharomyces pombe53.190.01175
LLPS-Usm-0327Ustilago maydis53.070.01179
LLPS-Anc-0167Anolis carolinensis52.950.01112
LLPS-Orn-0671Oreochromis niloticus52.950.01110
LLPS-Scm-0243Scophthalmus maximus52.90.01114
LLPS-Cym-0272Cyanidioschyzon merolae52.890.01171
LLPS-Ten-1234Tetraodon nigroviridis52.860.01124
LLPS-Pof-0741Poecilia formosa52.840.01117
LLPS-Spr-0254Sporisorium reilianum52.750.01150
LLPS-Scj-0480Schizosaccharomyces japonicus52.720.01138
LLPS-Orl-1709Oryzias latipes52.720.01109
LLPS-Xim-0584Xiphophorus maculatus52.710.01117
LLPS-Pes-0696Pelodiscus sinensis52.670.01106
LLPS-Dar-1540Danio rerio52.50.01108
LLPS-Chc-0380Chondrus crispus52.320.01019
LLPS-Tar-3000Takifugu rubripes52.310.01119
LLPS-Leo-0048Lepisosteus oculatus52.310.01106
LLPS-Asm-2141Astyanax mexicanus52.180.01110
LLPS-Rhb-3267Rhinopithecus bieti52.160.01062
LLPS-Scf-1622Scleropages formosus52.150.01106
LLPS-Gaa-1630Gasterosteus aculeatus51.960.01103
LLPS-Scc-0492Schizosaccharomyces cryophilus51.910.01126
LLPS-Icp-1029Ictalurus punctatus51.780.01100
LLPS-Lac-0209Latimeria chalumnae51.740.01077
LLPS-Asni-0246Aspergillus niger51.740.01100
LLPS-Tum-1047Tuber melanosporum51.570.01063
LLPS-Yal-0163Yarrowia lipolytica51.570.01085
LLPS-Asfu-0179Aspergillus fumigatus51.470.01101
LLPS-Ast-0202Aspergillus terreus51.440.01093
LLPS-Abg-0817Absidia glauca51.380.01110
LLPS-Nef-1046Neosartorya fischeri51.30.01097
LLPS-Asc-0911Aspergillus clavatus51.210.01093
LLPS-Asf-0248Aspergillus flavus51.080.01073
LLPS-Sac-0083Saccharomyces cerevisiae50.980.01092
LLPS-Aso-1019Aspergillus oryzae50.90.01071
LLPS-Cae-1575Caenorhabditis elegans50.570.01075
LLPS-Drm-0188Drosophila melanogaster50.530.01087
LLPS-Cii-0479Ciona intestinalis50.490.01076
LLPS-Zyt-0916Zymoseptoria tritici50.310.01027
LLPS-Pytr-0629Pyrenophora triticirepentis49.870.01030
LLPS-Pyt-0241Pyrenophora teres49.870.01033
LLPS-Nec-0668Neurospora crassa49.870.01020
LLPS-Cis-1243Ciona savignyi49.730.01055
LLPS-Lem-0998Leptosphaeria maculans49.420.01017
LLPS-Phn-0227Phaeosphaeria nodorum49.290.01018
LLPS-Trr-0821Trichoderma reesei49.250.01029
LLPS-Asn-0375Aspergillus nidulans49.240.01034
LLPS-Trv-0987Trichoderma virens49.160.01033
LLPS-Map-0379Magnaporthe poae49.030.01012
LLPS-Scs-0101Sclerotinia sclerotiorum49.020.01031
LLPS-Fus-0152Fusarium solani48.980.01035
LLPS-Fuo-0011Fusarium oxysporum48.850.01016
LLPS-Dos-0710Dothistroma septosporum48.820.01049
LLPS-Xet-1459Xenopus tropicalis48.760.0 986
LLPS-Fuv-0088Fusarium verticillioides48.670.01017
LLPS-Gag-0900Gaeumannomyces graminis48.630.01015
LLPS-Mao-1191Magnaporthe oryzae48.590.01000
LLPS-Asg-0496Ashbya gossypii48.550.01040
LLPS-Coo-0483Colletotrichum orbiculare48.320.01020
LLPS-Beb-0468Beauveria bassiana48.240.01016
LLPS-Cog-1118Colletotrichum gloeosporioides47.960.01015
LLPS-Cogr-1118Colletotrichum graminicola47.610.01013
LLPS-Ved-0061Verticillium dahliae47.580.01008
LLPS-Kop-0824Komagataella pastoris47.40.0 989
LLPS-Blg-0912Blumeria graminis44.960.01027