DrLLPS - Data resource of LLPS

LLPS-Usm-0645
SPB4

Integrated Annotations

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	ATP-dependent rRNA helicase SPB4
Gene Name:	SPB4, UMAG_03268
Ensembl Gene:	UMAG_03268
Ensembl Protein:	KIS68697
Organism:	Ustilago maydis
Taxa ID:	237631
LLPS Type:	Others

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Nucleolus	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Mus musculus	LLPS-Mum-2319	Q6ZPL9	Client	Nucleolus	39.97	3e-106	344
Saccharomyces cerevisiae	LLPS-Sac-0362	P25808	Client	Nucleolus	38.16	1e-109	353
Homo sapiens	LLPS-Hos-2182	Q8NHQ9	Client	Nucleolus	40.00	1e-107	348
Arabidopsis thaliana	LLPS-Art-0896	Q9FLB0	Client	Nucleolus	38.74	9e-118	374

▼ FUNCTION

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	KIS68697	KIS68697
UniProt		Q4P9E5, SPB4_USTMA, A0A0D1C4W3
GeneBank	CM003147	KIS68697.1
RefSeq	XM_011391382.1	XP_011389684.1

▼ SEQUENCE

Protein Sequence (FASTA)
1 MSAEPSVQTT SSSGPTELRS APSYAGSWTK LTPPLTPWVV SLLSDLGFGQ MTPVQASTIP 60 61 LFVSHKDVVV EAVTGSGKTL AFVIPVLEML ARRTTRLKKD EVGALIVSPT RELAEQIYKV 120 121 LVMFLDAQNH AHVQAQQQQD QDEQDEQDEQ EAQSDSDTDP DASTALNNKR KSSNHLVARK 180 181 NMISGAQLVV GGSKCTPLDD YRQLRDSGAD ILVGTPGRLE ELLSKKGVKK SSLEVLVLDE 240 241 ADRLLDLGFT ENLRRILSLL PKQRRTGLFS ATMTDALSEL VRIGLRNPVR VVVKVEAKHK 300 301 TSSSIDDSRR TPATLQNLYQ LCRAQNKLAQ LARIVLFESS QNAISGGARK LIVYFSTCAQ 360 361 VNYFYSVFSQ VSILRQHRVK LYALHGKQTP SKRKSMFDTF VASTALDSGA SGASVLFCTD 420 421 VAARGLDLPD VDVVVQYDPP TDPKVFSHRC GRTARAGRNG RAIVMLHTGR EQDFVSYMRV 480 481 KRIPLSPYPY LSSTLHGILE PAEDDASAHD LELSIRDLAK TDREIFELSI RAYVSYVRAY 540 541 TKHEMSYIFR INELDLAGVA RAFALIRLPS MPELKSRQSA GTLIYNQEPI DFSSIPFKDK 600 601 AKQRIRLAKL SGDQAKPPAR IKASVDDAAQ LQDDQCDSHD SDDAHPNSSA TRAKNKRKLE 660 661 REKGAWSAQK ERKQARLANR EKRARKRTFL KTQAAESSSN AKHEPPQDDH DEHDWNDDYR 720 721 KLQKDKRQQR QRNKADRANS DNDDAMHFNS DSDAAAANAD AEPFFVI 767

Protein Sequence (FASTA)

1     MSAEPSVQTT  SSSGPTELRS  APSYAGSWTK  LTPPLTPWVV  SLLSDLGFGQ  MTPVQASTIP  60
61    LFVSHKDVVV  EAVTGSGKTL  AFVIPVLEML  ARRTTRLKKD  EVGALIVSPT  RELAEQIYKV  120
121   LVMFLDAQNH  AHVQAQQQQD  QDEQDEQDEQ  EAQSDSDTDP  DASTALNNKR  KSSNHLVARK  180
181   NMISGAQLVV  GGSKCTPLDD  YRQLRDSGAD  ILVGTPGRLE  ELLSKKGVKK  SSLEVLVLDE  240
241   ADRLLDLGFT  ENLRRILSLL  PKQRRTGLFS  ATMTDALSEL  VRIGLRNPVR  VVVKVEAKHK  300
301   TSSSIDDSRR  TPATLQNLYQ  LCRAQNKLAQ  LARIVLFESS  QNAISGGARK  LIVYFSTCAQ  360
361   VNYFYSVFSQ  VSILRQHRVK  LYALHGKQTP  SKRKSMFDTF  VASTALDSGA  SGASVLFCTD  420
421   VAARGLDLPD  VDVVVQYDPP  TDPKVFSHRC  GRTARAGRNG  RAIVMLHTGR  EQDFVSYMRV  480
481   KRIPLSPYPY  LSSTLHGILE  PAEDDASAHD  LELSIRDLAK  TDREIFELSI  RAYVSYVRAY  540
541   TKHEMSYIFR  INELDLAGVA  RAFALIRLPS  MPELKSRQSA  GTLIYNQEPI  DFSSIPFKDK  600
601   AKQRIRLAKL  SGDQAKPPAR  IKASVDDAAQ  LQDDQCDSHD  SDDAHPNSSA  TRAKNKRKLE  660
661   REKGAWSAQK  ERKQARLANR  EKRARKRTFL  KTQAAESSSN  AKHEPPQDDH  DEHDWNDDYR  720
721   KLQKDKRQQR  QRNKADRANS  DNDDAMHFNS  DSDAAAANAD  AEPFFVI  767

▼ KEYWORD

ID	Family
KW-0067	ATP-binding
KW-0175	Coiled coil
KW-0181	Complete proteome
KW-0347	Helicase
KW-0378	Hydrolase
KW-0547	Nucleotide-binding
KW-0539	Nucleus
KW-1185	Reference proteome
KW-0690	Ribosome biogenesis
KW-0694	RNA-binding
KW-0698	rRNA processing

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005730	Cellular Component	Nucleolus
GO:0005524	Molecular Function	ATP binding
GO:0004386	Molecular Function	Helicase activity
GO:0003723	Molecular Function	RNA binding
GO:0006364	Biological Process	RRNA processing

▼ KEGG

uma:UMAG_03268

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Anp-0720	Anas platyrhynchos	68.57	4e-21	102
LLPS-Spr-0968	Sporisorium reilianum	68.52	0.0	814
LLPS-Miv-0794	Microbotryum violaceum	66.67	1e-39	159
LLPS-Pes-1454	Pelodiscus sinensis	66.67	1e-19	97.8
LLPS-Urm-2671	Ursus maritimus	66.13	4e-16	86.3
LLPS-Ora-0681	Ornithorhynchus anatinus	65.71	5e-20	98.6
LLPS-Loa-0676	Loxodonta africana	65.66	2e-32	137
LLPS-Tag-1392	Taeniopygia guttata	64.89	3e-27	121
LLPS-Sah-0427	Sarcophilus harrisii	64.79	7e-20	98.2
LLPS-Fud-0163	Fukomys damarensis	64.65	5e-31	133
LLPS-Fec-2621	Felis catus	64.65	5e-29	127
LLPS-Gaga-0762	Gallus gallus	64.65	1e-31	135
LLPS-Mod-1687	Monodelphis domestica	64.29	2e-19	96.7
LLPS-Gog-0910	Gorilla gorilla	63.64	1e-29	129
LLPS-Caj-1035	Callithrix jacchus	63.64	1e-29	129
LLPS-Sus-1873	Sus scrofa	63.64	2e-30	130
LLPS-Mup-1521	Mustela putorius furo	63.64	7e-29	126
LLPS-Ova-0226	Ovis aries	63.64	1e-30	132
LLPS-Otg-1589	Otolemur garnettii	63.64	6e-30	129
LLPS-Fia-2004	Ficedula albicollis	63.64	5e-30	130
LLPS-Pat-0797	Pan troglodytes	63.64	9e-30	129
LLPS-Hos-2182	Homo sapiens	63.64	9e-30	129
LLPS-Cas-1045	Carlito syrichta	63.64	2e-29	128
LLPS-Nol-2121	Nomascus leucogenys	63.64	8e-30	129
LLPS-Poa-0630	Pongo abelii	63.64	8e-30	129
LLPS-Eqc-0464	Equus caballus	63.64	6e-30	130
LLPS-Maf-0999	Macaca fascicularis	62.63	1e-28	125
LLPS-Chs-1537	Chlorocebus sabaeus	62.63	1e-28	125
LLPS-Ran-1055	Rattus norvegicus	62.63	4e-30	130
LLPS-Paa-0598	Papio anubis	62.63	1e-28	125
LLPS-Mal-0049	Mandrillus leucophaeus	62.63	1e-28	125
LLPS-Tut-0301	Tursiops truncatus	62.63	5e-30	130
LLPS-Bot-2507	Bos taurus	62.63	8e-30	130
LLPS-Orc-0532	Oryctolagus cuniculus	62.63	6e-29	126
LLPS-Rhb-3026	Rhinopithecus bieti	62.63	2e-28	125
LLPS-Pap-2440	Pan paniscus	62.63	2e-29	128
LLPS-Man-0173	Macaca nemestrina	62.63	2e-28	125
LLPS-Ict-0227	Ictidomys tridecemlineatus	62.63	1e-29	129
LLPS-Mam-2164	Macaca mulatta	62.63	1e-28	125
LLPS-Aim-1048	Ailuropoda melanoleuca	62.0	3e-29	127
LLPS-Mum-2319	Mus musculus	61.62	8e-30	129
LLPS-Mea-2168	Mesocricetus auratus	60.61	4e-29	127
LLPS-Lac-2074	Latimeria chalumnae	59.6	2e-27	121
LLPS-Cii-0877	Ciona intestinalis	59.22	2e-27	122
LLPS-Dar-0199	Danio rerio	59.0	1e-26	119
LLPS-Asm-1737	Astyanax mexicanus	58.42	6e-27	120
LLPS-Icp-0402	Ictalurus punctatus	58.42	7e-26	117
LLPS-Cus-0220	Cucumis sativus	58.06	3e-24	112
LLPS-Leo-2182	Lepisosteus oculatus	58.0	2e-26	119
LLPS-Cis-0988	Ciona savignyi	57.84	8e-27	120
LLPS-Anc-1595	Anolis carolinensis	57.58	1e-27	122
LLPS-Thc-0534	Theobroma cacao	57.45	2e-21	103
LLPS-Orb-0544	Oryza barthii	57.14	3e-24	112
LLPS-Hov-1107	Hordeum vulgare	57.14	3e-23	109
LLPS-Brd-0421	Brachypodium distachyon	57.14	2e-23	110
LLPS-Tra-0407	Triticum aestivum	57.14	1e-23	110
LLPS-Org-0675	Oryza glaberrima	57.14	3e-24	112
LLPS-Scf-1856	Scleropages formosus	56.86	2e-26	119
LLPS-Php-0917	Physcomitrella patens	56.57	6e-24	111
LLPS-Xet-0517	Xenopus tropicalis	56.57	4e-27	121
LLPS-Orni-0147	Oryza nivara	56.12	2e-23	110
LLPS-Ori-1932	Oryza indica	56.12	1e-23	110
LLPS-Orgl-1123	Oryza glumaepatula	56.12	8e-24	111
LLPS-Ors-0966	Oryza sativa	56.12	2e-23	110
LLPS-Orp-1619	Oryza punctata	56.12	1e-23	110
LLPS-Orr-1497	Oryza rufipogon	56.12	2e-23	110
LLPS-Orm-0980	Oryza meridionalis	56.12	2e-23	110
LLPS-Scm-1202	Scophthalmus maximus	56.0	4e-26	118
LLPS-Ten-0494	Tetraodon nigroviridis	56.0	4e-27	121
LLPS-Gaa-0594	Gasterosteus aculeatus	55.88	1e-27	123
LLPS-Abg-0776	Absidia glauca	55.75	1e-30	131
LLPS-Orl-2837	Oryzias latipes	55.24	1e-26	119
LLPS-Orbr-0553	Oryza brachyantha	55.1	1e-22	107
LLPS-Tar-1510	Takifugu rubripes	55.0	1e-26	119
LLPS-Asg-0517	Ashbya gossypii	54.9	5e-24	112
LLPS-Tum-0141	Tuber melanosporum	54.9	3e-25	115
LLPS-Orn-0361	Oreochromis niloticus	54.46	6e-27	120
LLPS-Hea-0069	Helianthus annuus	54.08	4e-22	105
LLPS-Sei-1307	Setaria italica	54.08	1e-21	104
LLPS-Lep-0510	Leersia perrieri	54.08	1e-21	103
LLPS-Xim-0701	Xiphophorus maculatus	54.0	1e-21	103
LLPS-Pof-0915	Poecilia formosa	54.0	3e-21	103
LLPS-Pyt-0340	Pyrenophora teres	53.54	7e-24	111
LLPS-Pytr-0254	Pyrenophora triticirepentis	53.54	9e-24	110
LLPS-Kop-0679	Komagataella pastoris	52.88	7e-24	111
LLPS-Gor-0103	Gossypium raimondii	52.53	1e-20	100
LLPS-Mua-1463	Musa acuminata	52.04	4e-21	102
LLPS-Dac-0176	Daucus carota	52.04	3e-20	99.8
LLPS-Mae-0491	Manihot esculenta	52.04	4e-21	102
LLPS-Viv-0908	Vitis vinifera	52.04	9e-21	101
LLPS-Coc-0803	Corchorus capsularis	52.04	1e-21	103
LLPS-Prp-0950	Prunus persica	52.04	1e-20	100
LLPS-Sac-0362	Saccharomyces cerevisiae	51.96	2e-22	106
LLPS-Brn-0527	Brassica napus	51.52	5e-20	99.0
LLPS-Brr-0100	Brassica rapa	51.52	5e-20	99.0
LLPS-Bro-1351	Brassica oleracea	51.52	4e-20	99.0
LLPS-Pot-0121	Populus trichocarpa	51.02	3e-20	99.8
LLPS-Arl-0900	Arabidopsis lyrata	51.0	2e-19	97.1
LLPS-Art-0896	Arabidopsis thaliana	51.0	3e-19	96.7
LLPS-Amt-0611	Amborella trichopoda	50.54	6e-19	95.9
LLPS-Cap-0080	Cavia porcellus	49.61	1e-24	113
LLPS-Zyt-0189	Zymoseptoria tritici	48.0	1e-20	101
LLPS-Nia-1522	Nicotiana attenuata	47.96	4e-19	96.3
LLPS-Meg-1089	Meleagris gallopavo	47.47	9e-15	82.0
LLPS-Caf-0823	Canis familiaris	46.92	3e-24	112
LLPS-Crn-0466	Cryptococcus neoformans	44.74	4e-115	372
LLPS-Put-0986	Puccinia triticina	43.37	3e-70	248
LLPS-Mao-0482	Magnaporthe oryzae	43.34	3e-107	348
LLPS-Gag-0215	Gaeumannomyces graminis	42.86	8e-104	339
LLPS-Map-0148	Magnaporthe poae	42.56	3e-102	335
LLPS-Scs-0407	Sclerotinia sclerotiorum	42.47	2e-102	335
LLPS-Asn-0263	Aspergillus nidulans	41.98	5e-101	332
LLPS-Fuo-0150	Fusarium oxysporum	41.85	1e-100	331
LLPS-Fus-0538	Fusarium solani	41.68	2e-99	327
LLPS-Ved-1439	Verticillium dahliae	41.64	2e-62	221
LLPS-Beb-0583	Beauveria bassiana	41.25	4e-101	332
LLPS-Fuv-1404	Fusarium verticillioides	41.12	8e-99	326
LLPS-Aso-0411	Aspergillus oryzae	41.12	7e-103	337
LLPS-Phv-0394	Phaseolus vulgaris	40.99	6e-96	317
LLPS-Asc-0579	Aspergillus clavatus	40.82	5e-101	332
LLPS-Asf-0570	Aspergillus flavus	40.61	5e-66	236
LLPS-Glm-0404	Glycine max	40.54	5e-97	322
LLPS-Sot-0556	Solanum tuberosum	40.52	3e-65	234
LLPS-Asni-0473	Aspergillus niger	40.51	2e-94	314
LLPS-Via-0088	Vigna angularis	40.48	6e-96	317
LLPS-Mel-0595	Melampsora laricipopulina	40.46	3e-94	310
LLPS-Vir-0320	Vigna radiata	40.42	7e-94	310
LLPS-Myl-2154	Myotis lucifugus	40.4	4e-08	61.2
LLPS-Blg-0591	Blumeria graminis	40.3	3e-98	324
LLPS-Met-0899	Medicago truncatula	39.93	4e-92	306
LLPS-Yal-0199	Yarrowia lipolytica	39.86	7e-97	320
LLPS-Sob-0860	Sorghum bicolor	39.47	6e-93	310
LLPS-Nec-0807	Neurospora crassa	39.35	5e-93	311
LLPS-Ast-0594	Aspergillus terreus	39.18	7e-100	329
LLPS-Trv-0184	Trichoderma virens	39.01	6e-108	350
LLPS-Cogr-1005	Colletotrichum graminicola	38.99	3e-94	313
LLPS-Coo-0288	Colletotrichum orbiculare	38.81	1e-97	322
LLPS-Lem-0546	Leptosphaeria maculans	38.74	7e-107	347
LLPS-Phn-0084	Phaeosphaeria nodorum	38.65	2e-111	359
LLPS-Nef-0090	Neosartorya fischeri	38.61	1e-100	330
LLPS-Asfu-0345	Aspergillus fumigatus	38.52	9e-99	326
LLPS-Sem-0682	Selaginella moellendorffii	38.37	8e-91	303
LLPS-Trr-0804	Trichoderma reesei	38.27	1e-107	348
LLPS-Pug-0949	Puccinia graminis	38.16	8e-105	345
LLPS-Dio-1547	Dipodomys ordii	38.01	2e-46	178
LLPS-Cea-1082	Cercocebus atys	37.9	2e-80	276
LLPS-Scj-0362	Schizosaccharomyces japonicus	37.88	1e-92	310
LLPS-Scp-0666	Schizosaccharomyces pombe	37.85	2e-94	313
LLPS-Drm-0395	Drosophila melanogaster	37.79	7e-81	277
LLPS-Osl-0260	Ostreococcus lucimarinus	37.76	1e-82	281
LLPS-Cog-0655	Colletotrichum gloeosporioides	37.7	2e-94	314
LLPS-Cae-0656	Caenorhabditis elegans	37.5	1e-10	68.9
LLPS-Scc-0231	Schizosaccharomyces cryophilus	37.14	7e-86	290
LLPS-Chc-0066	Chondrus crispus	35.47	7e-41	160
LLPS-Zem-1482	Zea mays	34.56	7e-80	277
LLPS-Dos-0709	Dothistroma septosporum	34.18	4e-74	259
LLPS-Aon-2065	Aotus nancymaae	30.73	9e-44	174
LLPS-Gas-0122	Galdieria sulphuraria	29.36	3e-37	152
LLPS-Cym-0346	Cyanidioschyzon merolae	29.17	1e-43	172

LLPS-Usm-0645SPB4

Protein Sequence

Nucleotide Sequence

LLPS-Usm-0645
SPB4