LLPS-Urm-a586
TAMM41
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Phosphatidate cytidylyltransferase, mitochondrial; CDP-diacylglycerol synthase; Mitochondrial translocator assembly and maintenance protein 41 homolog |
| Gene Name: | TAMM41 |
| Ensembl Gene: | ENSUMAG00000017859.1 |
| Ensembl Protein: | ENSUMAP00000024559.1 |
| Organism: | Ursus maritimus |
| Taxa ID: | 29073 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSUMAT00000029084.1 | ENSUMAP00000024559.1 |
| Ensembl | ENSUMAT00000029077.1 | ENSUMAP00000024552.1 |
| UniProt | A0A384CNP3, A0A384CNP3_URSMA | |
| RefSeq | , XM_008697872.1 | , XP_008696094.1, XP_008696094.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MALQALQSSG VAFRKILSHF PEELSLAFAY GSGVYRQVGP SSDQKNAMLD FVFTVDDPVA 60 61 WHSQNLKKNW SHYSFLKVLG PKIITTIQNN YGAGVYYNPL ITCDGRLIKY GVISTNILIE 120 121 DLLNWNNLYV AGRLQKPVKI IAMNENVALR SALDKNLKSA VTTAFLMLPE SFSEEDLFIE 180 181 IAGLSYSGDF RMVVGEDKTK VLNIVKPNIA HFRELYGNIL QENPQVVYKI QQGRLEIDKS 240 241 PEGQFTQLMT LPKTLQQQIN HIMDPPGKNR DVEETLFQVA HDPDCGEVVR LGLSAIVRPS 300 301 SMKQSTKGIF TAGVKKSVVY SSLKLHKMWK GWLRKAS 337 |
▼ KEYWORD
ID | Family |
Complete proteome | |
Lipid biosynthesis | |
Lipid metabolism | |
Magnesium | |
Membrane | |
Mitochondrion | |
Mitochondrion inner membrane | |
Nucleotidyltransferase | |
Phospholipid biosynthesis | |
Phospholipid metabolism | |
Reference proteome | |
Transferase
|
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Mitochondrial inner membrane | |
Molecular Function | Phosphatidate cytidylyltransferase activity | |
Biological Process | Cardiolipin biosynthetic process | |
Biological Process | CDP-diacylglycerol biosynthetic process |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Hos-a647 | Homo sapiens | 0.0 | 605 | undefined |
| LLPS-Mum-a641 | Mus musculus | 0.0 | 605 | undefined |