• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Urm-2371
MKRN2

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: probable E3 ubiquitin-protein ligase makorin-2
Gene Name: MKRN2
Ensembl Gene: ENSUMAG00000017606.1
Ensembl Protein: ENSUMAP00000024167.1
Organism: Ursus maritimus
Taxa ID: 29073
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
P-body, Stress granulePredicted from orthologs(View)

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MHGVCREGNQ  CLFSHDLANS  KPSTICKYYQ  KGYCAYGTRC  RYDHTRPSAA  AGGAVGTVPH  60
61    GVPSPGFHGP  HPASDLTASI  VKTNLHEPGK  REKRTLVLRD  RNLSGMAEEK  TCPSVVSNPG  120
121   GCSDPQNSPE  MKPHSYLDAI  RSGLDDLEAS  SSYSSEQQLC  PYAAAGECRF  GDACVYLHGE  180
181   VCEICRLRVL  HPFDPEQRKT  HEKICMSTFE  HEMEKAFAFQ  ASQDKVCSIC  MEVVLEKASA  240
241   SERRFGILSN  CNHTYCLSCI  RQWRCAKQFE  NPIIKSCPEC  RVISEFVIPS  VYWVEDQNKK  300
301   NELIEAFKQG  MGKKACKYFE  QGKGTCPFGS  KCLYRHAYPD  GRLAEPEKPR  KQLSSEGTVR  360
361   FLNSVRLWDF  IENRETRHVP  NTEDVDMTEL  GDLFMHLSGV  ESSEP  405
Nucleotide CDS Sequence (FASTA)
1     ATGCATGGTG  TGTGTCGGGA  AGGAAACCAG  TGCCTGTTCT  CACATGACTT  GGCGAACAGC  60
61    AAGCCATCCA  CCATCTGCAA  ATACTATCAG  AAGGGCTACT  GCGCCTATGG  GACTCGTTGC  120
121   AGATATGATC  ACACGAGGCC  TTCTGCTGCA  GCTGGTGGTG  CCGTGGGCAC  TGTGCCCCAC  180
181   GGTGTGCCCT  CCCCGGGTTT  CCACGGTCCT  CACCCTGCTT  CCGACCTCAC  TGCGTCTATT  240
241   GTGAAAACTA  ACTTACATGA  GCCTGGGAAA  CGTGAAAAGA  GAACGTTGGT  ACTTAGAGAC  300
301   CGAAATCTCT  CTGGCATGGC  TGAGGAAAAG  ACTTGCCCAA  GTGTCGTGAG  TAATCCAGGA  360
361   GGCTGCAGTG  ATCCCCAGAA  CAGCCCAGAG  ATGAAGCCAC  ATTCCTACCT  CGATGCGATC  420
421   AGGAGTGGCC  TTGATGACTT  AGAAGCCAGC  AGCTCCTACA  GCAGTGAGCA  GCAGCTGTGC  480
481   CCCTATGCGG  CGGCTGGGGA  GTGCCGATTT  GGGGATGCTT  GTGTCTACCT  GCATGGAGAA  540
541   GTGTGTGAAA  TCTGTAGGTT  ACGAGTCCTG  CATCCCTTCG  ACCCAGAGCA  AAGGAAAACT  600
601   CATGAGAAGA  TCTGCATGTC  AACATTCGAA  CATGAGATGG  AAAAGGCCTT  TGCCTTCCAA  660
661   GCAAGTCAGG  ACAAAGTGTG  CAGTATCTGC  ATGGAAGTGG  TCCTTGAGAA  GGCGTCTGCT  720
721   TCTGAGAGGA  GATTTGGGAT  TCTCTCCAAC  TGCAATCACA  CGTACTGCTT  GTCCTGCATC  780
781   CGGCAGTGGA  GATGTGCCAA  GCAGTTTGAG  AACCCAATCA  TTAAGTCTTG  TCCAGAATGC  840
841   CGTGTGATAT  CCGAGTTTGT  AATTCCAAGT  GTGTATTGGG  TAGAAGATCA  GAATAAAAAG  900
901   AACGAGTTGA  TTGAAGCTTT  CAAACAGGGA  ATGGGGAAAA  AAGCTTGTAA  ATACTTTGAG  960
961   CAAGGCAAGG  GGACGTGCCC  ATTTGGAAGC  AAATGCCTTT  ACCGCCACGC  TTATCCTGAT  1020
1021  GGGCGGCTGG  CAGAGCCGGA  GAAGCCTCGG  AAGCAGCTCA  GTTCCGAGGG  CACCGTGAGG  1080
1081  TTCTTGAATT  CAGTGCGGCT  CTGGGATTTC  ATTGAGAATC  GAGAAACCCG  GCATGTCCCC  1140
1141  AACACTGAAG  ATGTCGACAT  GACAGAGCTT  GGGGACCTCT  TCATGCACCT  GTCTGGAGTG  1200
1201  GAGTCGTCAG  AACCCTAA  1218

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Aim-3332Ailuropoda melanoleuca98.520.0 832
LLPS-Fec-1555Felis catus98.270.0 833
LLPS-Caf-3056Canis familiaris97.280.0 826
LLPS-Mup-3609Mustela putorius furo96.790.0 825
LLPS-Eqc-1115Equus caballus95.560.0 801
LLPS-Sus-4450Sus scrofa95.310.0 810
LLPS-Myl-4195Myotis lucifugus94.570.0 781
LLPS-Chs-4608Chlorocebus sabaeus93.830.0 800
LLPS-Maf-2698Macaca fascicularis93.830.0 801
LLPS-Cea-1496Cercocebus atys93.830.0 800
LLPS-Paa-3012Papio anubis93.830.0 800
LLPS-Mal-2325Mandrillus leucophaeus93.830.0 800
LLPS-Hos-0316Homo sapiens93.830.0 801
LLPS-Man-2846Macaca nemestrina93.830.0 800
LLPS-Rhb-4718Rhinopithecus bieti93.830.0 800
LLPS-Pap-3789Pan paniscus93.580.0 797
LLPS-Pat-1787Pan troglodytes93.580.0 797
LLPS-Poa-3957Pongo abelii93.580.0 797
LLPS-Gog-0864Gorilla gorilla93.330.0 795
LLPS-Mam-1796Macaca mulatta93.330.0 792
LLPS-Otg-1586Otolemur garnettii92.980.0 777
LLPS-Nol-1036Nomascus leucogenys92.840.0 786
LLPS-Caj-2902Callithrix jacchus92.590.0 785
LLPS-Aon-3007Aotus nancymaae92.330.0 783
LLPS-Ict-0004Ictidomys tridecemlineatus91.60.0 775
LLPS-Loa-4038Loxodonta africana91.360.0 782
LLPS-Orc-2699Oryctolagus cuniculus90.860.0 753
LLPS-Bot-2719Bos taurus90.840.0 779
LLPS-Ova-3188Ovis aries90.350.0 773
LLPS-Mea-3593Mesocricetus auratus89.140.0 750
LLPS-Ran-3933Rattus norvegicus88.670.0 741
LLPS-Mum-4755Mus musculus88.640.0 743
LLPS-Fud-2320Fukomys damarensis86.70.0 733
LLPS-Cap-3941Cavia porcellus86.420.0 701
LLPS-Dio-3361Dipodomys ordii86.390.0 724
LLPS-Sah-0031Sarcophilus harrisii83.420.0 697
LLPS-Mod-1220Monodelphis domestica83.170.0 710
LLPS-Scm-1772Scophthalmus maximus77.081e-1788.6
LLPS-Pes-0025Pelodiscus sinensis75.980.0 642
LLPS-Anc-3533Anolis carolinensis75.120.0 612
LLPS-Anp-1797Anas platyrhynchos74.810.0 614
LLPS-Meg-0623Meleagris gallopavo73.570.0 536
LLPS-Gaga-2905Gallus gallus73.570.0 586
LLPS-Tag-0964Taeniopygia guttata68.060.0 545
LLPS-Fia-2128Ficedula albicollis67.480.0 524
LLPS-Lac-2782Latimeria chalumnae65.530.0 557
LLPS-Icp-1140Ictalurus punctatus62.282e-174 501
LLPS-Asm-2977Astyanax mexicanus61.794e-173 498
LLPS-Scf-1438Scleropages formosus60.744e-173 498
LLPS-Leo-3089Lepisosteus oculatus59.861e-174 501
LLPS-Dar-1251Danio rerio58.254e-164 474
LLPS-Pof-0404Poecilia formosa57.991e-159 462
LLPS-Orn-3326Oreochromis niloticus57.81e-158 461
LLPS-Gaa-1311Gasterosteus aculeatus56.075e-160 464
LLPS-Orl-0716Oryzias latipes55.239e-155 452
LLPS-Ten-2821Tetraodon nigroviridis53.468e-143 420
LLPS-Tar-0664Takifugu rubripes53.032e-145 426
LLPS-Sem-0991Selaginella moellendorffii50.01e-0757.0
LLPS-Art-2731Arabidopsis thaliana48.987e-0857.8
LLPS-Scp-1410Schizosaccharomyces pombe47.835e-0859.3
LLPS-Scj-1297Schizosaccharomyces japonicus45.652e-0757.0
LLPS-Kop-1113Komagataella pastoris41.39e-0651.6
LLPS-Brr-0120Brassica rapa40.452e-51 181
LLPS-Osl-0727Ostreococcus lucimarinus39.875e-35 132
LLPS-Ere-0932Erinaceus europaeus39.831e-73 244
LLPS-Brn-2197Brassica napus39.464e-50 177
LLPS-Bro-1545Brassica oleracea39.464e-50 177
LLPS-Scc-1590Schizosaccharomyces cryophilus37.54e-0859.3
LLPS-Met-0247Medicago truncatula36.76e-71 233
LLPS-Cae-1580Caenorhabditis elegans36.677e-60 206
LLPS-Nia-2444Nicotiana attenuata36.414e-75 244
LLPS-Phv-2087Phaseolus vulgaris36.23e-71 234
LLPS-Vir-0715Vigna radiata36.153e-60 209
LLPS-Mae-1060Manihot esculenta36.072e-69 230
LLPS-Gor-0077Gossypium raimondii35.992e-68 227
LLPS-Orbr-2161Oryza brachyantha35.981e-66 223
LLPS-Mua-0120Musa acuminata35.975e-70 231
LLPS-Glm-2838Glycine max35.961e-68 228
LLPS-Via-0159Vigna angularis35.842e-69 230
LLPS-Sol-2054Solanum lycopersicum35.511e-64 217
LLPS-Ori-2042Oryza indica35.194e-67 224
LLPS-Orb-0175Oryza barthii35.195e-67 224
LLPS-Ors-0086Oryza sativa35.195e-67 223
LLPS-Orgl-2288Oryza glumaepatula34.929e-66 221
LLPS-Orp-0621Oryza punctata34.99e-67 224
LLPS-Pot-2210Populus trichocarpa34.823e-69 230
LLPS-Lep-0656Leersia perrieri34.789e-66 224
LLPS-Hea-2544Helianthus annuus34.721e-65 219
LLPS-Php-1059Physcomitrella patens34.487e-69 228
LLPS-Arl-2109Arabidopsis lyrata34.466e-66 220
LLPS-Brd-2426Brachypodium distachyon34.112e-68 228
LLPS-Drm-1410Drosophila melanogaster33.982e-69 231
LLPS-Coc-2197Corchorus capsularis33.984e-59 202
LLPS-Viv-1198Vitis vinifera33.941e-64 220
LLPS-Orni-1908Oryza nivara33.618e-59 202
LLPS-Orr-2192Oryza rufipogon33.618e-59 202
LLPS-Tru-1951Triticum urartu33.612e-63 216
LLPS-Tra-0378Triticum aestivum33.251e-67 226
LLPS-Sob-1481Sorghum bicolor33.252e-65 219
LLPS-Prp-0880Prunus persica33.141e-56 197
LLPS-Sei-0519Setaria italica33.081e-65 220
LLPS-Hov-1456Hordeum vulgare32.997e-67 226
LLPS-Zem-2563Zea mays32.993e-61 209
LLPS-Thc-2305Theobroma cacao32.951e-58 204
LLPS-Mel-1298Melampsora laricipopulina27.055e-1787.0