LLPS-Urm-1351
TNP2
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Nuclear transition protein 2 |
| Gene Name: | TNP2 |
| Ensembl Gene: | ENSUMAG00000003930.1 |
| Ensembl Protein: | ENSUMAP00000004916.1 |
| Organism: | Ursus maritimus |
| Taxa ID: | 29073 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus, Chromatoid body | Predicted from orthologs | (View) |
▼ FUNCTION
| Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSUMAT00000005949.1 | ENSUMAP00000004916.1 |
| UniProt | A0A384CKK6, A0A384CKK6_URSMA | |
| RefSeq | , XM_008697130.1 | , XP_008695352.1, XP_008695352.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MDTKTQSLPN THTQPHSNSR PQSHTCSPCT CSSHCQTCSQ SCARSQSCSR SRSSSQSPTG 60 61 HQSQSPHPSP PPRHRKHTMH SHHCPPWPTT HSCSYPKNRK NLEGKVNKRK VAKRSQQVYK 120 121 TKRRIGQRKV GVLMGGWPSW LNNDWLGGWM IRIVDGLTGR 160 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGACACCA AGACACAGAG CCTTCCCAAC ACCCACACCC AGCCCCATAG CAACTCTCGG 60 61 CCGCAGAGCC ACACCTGCAG CCCGTGCACC TGCAGCTCCC ACTGCCAAAC TTGCAGCCAG 120 121 AGCTGCGCCC GGAGCCAGAG TTGCAGCCGG AGCCGAAGCT CCAGCCAGAG CCCGACTGGC 180 181 CACCAGAGCC AGAGTCCGCA CCCCAGCCCG CCACCGAGGC ACCGAAAGCA TACCATGCAC 240 241 TCCCACCACT GTCCCCCGTG GCCCACCACC CATTCCTGCA GCTACCCCAA GAACAGAAAG 300 301 AATTTGGAAG GAAAGGTGAA CAAGAGGAAG GTGGCCAAGA GGAGCCAGCA GGTGTATAAA 360 361 ACAAAGAGGC GGATTGGACA GAGGAAGGTA GGAGTGTTGA TGGGAGGATG GCCGAGTTGG 420 421 TTAAACAATG ATTGGCTAGG CGGGTGGATG ATCAGAATAG TGGATGGACT GACGGGGAGA 480 481 TGA 483 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Nucleosome | |
Cellular Component | Nucleus | |
Molecular Function | DNA binding | |
Molecular Function | Metal ion binding | |
Biological Process | Cell differentiation | |
Biological Process | Intracellular signal transduction | |
Biological Process | Multicellular organism development | |
Biological Process | Protein ubiquitination | |
Biological Process | Spermatogenesis |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Mup-2242 | Mustela putorius furo | 86.82 | 5e-28 | 107 |
| LLPS-Bot-3907 | Bos taurus | 70.37 | 2e-15 | 73.6 |
| LLPS-Sus-2642 | Sus scrofa | 69.64 | 2e-15 | 73.9 |
| LLPS-Hos-1042 | Homo sapiens | 67.35 | 9e-07 | 49.3 |
| LLPS-Poa-1093 | Pongo abelii | 67.35 | 1e-11 | 63.2 |
| LLPS-Maf-1859 | Macaca fascicularis | 66.67 | 2e-12 | 65.9 |
| LLPS-Gog-1844 | Gorilla gorilla | 66.67 | 3e-08 | 53.1 |
| LLPS-Paa-4233 | Papio anubis | 66.67 | 2e-12 | 65.9 |
| LLPS-Pap-0617 | Pan paniscus | 66.67 | 4e-10 | 58.5 |
| LLPS-Man-2764 | Macaca nemestrina | 66.67 | 2e-12 | 65.9 |
| LLPS-Nol-1332 | Nomascus leucogenys | 66.67 | 8e-13 | 66.6 |
| LLPS-Chs-2439 | Chlorocebus sabaeus | 64.81 | 6e-12 | 63.9 |
| LLPS-Ova-0259 | Ovis aries | 64.81 | 6e-12 | 63.9 |
| LLPS-Pat-2288 | Pan troglodytes | 64.81 | 9e-12 | 63.5 |
| LLPS-Rhb-2243 | Rhinopithecus bieti | 64.81 | 8e-12 | 63.9 |
| LLPS-Mam-2069 | Macaca mulatta | 64.81 | 3e-12 | 64.7 |
| LLPS-Cea-0255 | Cercocebus atys | 62.96 | 2e-11 | 62.4 |
| LLPS-Mal-0217 | Mandrillus leucophaeus | 62.96 | 3e-11 | 62.0 |
| LLPS-Caf-1617 | Canis familiaris | 61.24 | 4e-28 | 107 |
| LLPS-Aon-2874 | Aotus nancymaae | 61.22 | 6e-08 | 52.4 |
| LLPS-Orc-0533 | Oryctolagus cuniculus | 60.34 | 3e-11 | 62.0 |
| LLPS-Caj-0870 | Callithrix jacchus | 59.65 | 3e-10 | 58.9 |
| LLPS-Fec-0829 | Felis catus | 58.91 | 1e-16 | 76.6 |
| LLPS-Cas-0089 | Carlito syrichta | 51.79 | 1e-06 | 48.5 |