• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Tut-2184
VPS35

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: Vacuolar protein sorting-associated protein 35
Gene Name: VPS35
Ensembl Gene: ENSTTRG00000013280.1
Ensembl Protein: ENSTTRP00000012605.1
Organism: Tursiops truncatus
Taxa ID: 9739
LLPS Type: Others


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Chromatoid body, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION


Plays a role in vesicular protein sorting.

▼ CROSS REFERENCE


▼ SEQUENCE


Protein Sequence (FASTA)
1     MPTTQQSPQD  EQEKLLDEAI  QAVKVQSFQM  KRCLDKNKLM  DALKHASNML  GELRTSMLSP  60
61    KSYYELYMAI  SDELHYLEVY  LTDEFAKGRK  VADLYELVQY  AGNIIPRLYL  LITVGVVYVK  120
121   SFPQSRKDIL  KDLVEMCRGV  QHPLRGLFLR  NYLLQCTRNI  LPDEGEPTDE  ETTGDISDSM  180
181   DFVLLNFAEM  NKLWVRMQHQ  GHSRDREKRE  RERQELRILV  GTNLVRLSQL  EGVNVERYKQ  240
241   IVLTGILEQV  VNCRDALAQE  YLMECIIQVF  PDEFHLQTLN  PFLRACAELH  QNVNVKNIII  300
301   ALIDRLALFA  HREDGPGIPT  DIKLFDIFSQ  QVATVIQSRQ  DMPSEDVVSL  QVSLINLAMK  360
361   CYPDRVDYVD  KVLETTVEIF  NKLNLEHIAT  SSAVSKELTR  LLKIPVDTYN  NILTVLKLKH  420
421   FHPLFEYFDY  ESRKSMSCYV  LSNVLDYNTE  IVSQDQVDSI  MNLVSTLIQD  QPDQPVEDPD  480
481   PEDFADEQSL  VGRFIHLLRS  EDPDQQYLIL  NTARKHFGAG  GNQRIRFTLP  PLVFAAYQLA  540
541   FRYKENSKVD  DKWEKKCQKI  FSFAHQTISA  LIKAELAELP  LRLFLQGALA  AGEIGFENHE  600
601   TVAYEFMSQA  FSLYEDEISD  SKAQLAAITL  IIGTFERMKC  FSEENHEPLR  TQCALAASKL  660
661   LKKPDQGRAV  STCAHLFWSG  RNTDKNGEEL  HGGKRVMECL  KKALKIANQC  MDPSLQVQLF  720
721   IEILNRYIYF  YEKENDAVTI  QVLNQLIQKI  REDLPNLESS  EETEQINKHF  HNTLEHLRLR  780
781   RESPESEGPI  YEGLIL  796
Nucleotide CDS Sequence (FASTA)
1     ATGCCTACAA  CACAGCAGTC  ACCTCAGGAT  GAGCAGGAAA  AGCTCTTGGA  TGAAGCCATA  60
61    CAGGCTGTGA  AGGTCCAGTC  ATTCCAGATG  AAGAGATGCC  TGGACAAAAA  CAAGCTTATG  120
121   GATGCTCTGA  AACATGCTTC  TAATATGCTT  GGTGAACTTC  GGACTTCTAT  GTTATCACCA  180
181   AAGAGCTACT  ATGAACTTTA  TATGGCTATT  TCTGATGAAC  TGCACTACTT  GGAAGTTTAC  240
241   CTGACAGATG  AGTTTGCTAA  AGGAAGAAAA  GTGGCAGATC  TCTATGAACT  TGTACAGTAT  300
301   GCTGGAAACA  TTATTCCAAG  GCTTTATCTG  TTGATCACAG  TTGGAGTTGT  ATATGTCAAG  360
361   TCATTTCCTC  AATCCAGGAA  AGATATTTTG  AAAGATTTGG  TAGAAATGTG  CCGAGGTGTG  420
421   CAGCACCCTT  TGAGAGGCCT  GTTTCTTCGA  AACTATCTAC  TTCAGTGTAC  CAGAAACATC  480
481   TTACCTGATG  AAGGAGAGCC  AACAGATGAA  GAAACAACTG  GTGATATCAG  TGATTCCATG  540
541   GATTTTGTAC  TACTCAACTT  TGCAGAAATG  AACAAGCTCT  GGGTTCGAAT  GCAGCATCAG  600
601   GGACATAGCC  GAGATAGAGA  AAAAAGAGAA  CGAGAAAGAC  AAGAACTAAG  GATTTTAGTG  660
661   GGAACAAATT  TGGTGCGCCT  CAGTCAGTTG  GAAGGTGTAA  ATGTGGAACG  TTATAAACAG  720
721   ATTGTTTTGA  CTGGCATATT  GGAGCAAGTT  GTGAATTGCA  GGGATGCTTT  GGCTCAAGAA  780
781   TATCTCATGG  AGTGTATTAT  TCAGGTTTTC  CCTGACGAAT  TCCACCTTCA  AACTTTGAAT  840
841   CCTTTTCTTC  GGGCCTGTGC  TGAGTTACAC  CAAAATGTAA  ATGTGAAAAA  CATAATCATT  900
901   GCTTTAATTG  ATAGATTAGC  TTTATTTGCT  CACCGTGAAG  ATGGACCTGG  AATTCCAACA  960
961   GATATTAAAC  TTTTTGACAT  ATTTTCACAG  CAGGTGGCTA  CAGTAATACA  GTCGAGACAA  1020
1021  GACATGCCTT  CGGAGGACGT  TGTATCTTTA  CAAGTCTCTC  TCATTAATCT  CGCTATGAAG  1080
1081  TGTTATCCTG  ATCGTGTGGA  CTATGTTGAT  AAAGTTCTAG  AAACAACAGT  GGAGATATTT  1140
1141  AATAAGCTCA  ACCTCGAACA  TATTGCTACC  AGTAGTGCAG  TTTCAAAGGA  GCTCACCAGA  1200
1201  CTTCTGAAGA  TACCTGTTGA  CACTTACAAC  AATATTTTAA  CAGTCTTGAA  ATTAAAACAT  1260
1261  TTTCACCCAC  TCTTTGAGTA  CTTTGACTAT  GAATCCAGAA  AAAGCATGAG  TTGTTATGTG  1320
1321  CTTAGTAATG  TTCTGGATTA  TAACACAGAA  ATTGTCTCTC  AAGACCAGGT  GGATTCCATA  1380
1381  ATGAATTTGG  TATCAACGTT  GATTCAGGAT  CAGCCAGATC  AACCTGTAGA  AGACCCTGAC  1440
1441  CCAGAGGACT  TTGCTGATGA  GCAGAGCCTT  GTGGGCAGAT  TCATTCATCT  TCTACGGTCT  1500
1501  GAGGACCCTG  ATCAGCAGTA  CTTGATTTTA  AACACAGCAC  GAAAACATTT  TGGAGCTGGT  1560
1561  GGAAATCAGC  GGATTCGCTT  CACACTGCCA  CCTTTGGTAT  TTGCAGCTTA  CCAGCTGGCT  1620
1621  TTTCGCTACA  AAGAGAATTC  TAAAGTGGAT  GACAAATGGG  AAAAGAAATG  CCAGAAGATT  1680
1681  TTTTCATTTG  CTCACCAGAC  TATCAGTGCT  TTGATCAAAG  CAGAGCTGGC  AGAATTACCC  1740
1741  TTAAGACTTT  TTCTTCAGGG  CGCTCTAGCT  GCTGGAGAAA  TTGGTTTTGA  AAATCATGAA  1800
1801  ACAGTAGCAT  ATGAATTTAT  GTCCCAGGCA  TTTTCTTTGT  ATGAAGATGA  AATCAGTGAT  1860
1861  TCCAAAGCAC  AGCTGGCTGC  CATCACCTTG  ATCATTGGTA  CTTTTGAGAG  GATGAAGTGC  1920
1921  TTCAGTGAAG  AAAATCATGA  ACCTTTGAGG  ACTCAGTGTG  CTCTTGCTGC  ATCCAAACTT  1980
1981  CTGAAGAAAC  CTGATCAGGG  CCGAGCTGTG  AGCACCTGTG  CACATCTCTT  CTGGTCTGGC  2040
2041  AGAAACACAG  ACAAAAATGG  GGAGGAGCTT  CACGGAGGCA  AGAGGGTAAT  GGAATGCCTA  2100
2101  AAGAAAGCTC  TAAAAATAGC  AAATCAGTGC  ATGGACCCCT  CTTTACAAGT  GCAACTTTTT  2160
2161  ATAGAAATTC  TGAACAGATA  TATCTATTTT  TATGAAAAGG  AAAATGATGC  GGTCACGATT  2220
2221  CAGGTTTTGA  ATCAGCTTAT  CCAAAAGATT  CGAGAAGACC  TCCCAAATCT  TGAGTCCAGT  2280
2281  GAAGAAACAG  AGCAGATTAA  CAAACATTTT  CATAACACAC  TGGAGCATTT  GCGCTTGAGG  2340
2341  CGGGAATCAC  CGGAATCTGA  GGGGCCAATT  TACGAGGGAC  TCATCCTTTA  G  2391

▼ KEYWORD


ID
Family
Coiled coil
Complete proteome
Protein transport
Reference proteome
Transport

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Early endosome
Cellular Component
Endosome membrane
Cellular Component
Lysosome
Cellular Component
Mitochondrion
Cellular Component
Mitochondrion-derived vesicle
Cellular Component
Plasma membrane
Cellular Component
Retromer, cargo-selective complex
Cellular Component
Tubular endosome
Molecular Function
D1 dopamine receptor binding
Biological Process
Mitochondrial fragmentation involved in apoptotic process
Biological Process
Mitochondrion to lysosome transport
Biological Process
Negative regulation of inflammatory response
Biological Process
Negative regulation of late endosome to lysosome transport
Biological Process
Negative regulation of neuron death
Biological Process
Neurotransmitter receptor transport, endosome to plasma membrane
Biological Process
Positive regulation of cellular protein catabolic process
Biological Process
Positive regulation of dopamine receptor signaling pathway
Biological Process
Positive regulation of gene expression
Biological Process
Positive regulation of mitochondrial fission
Biological Process
Regulation of dendritic spine maintenance
Biological Process
Regulation of protein stability
Biological Process
Regulation of terminal button organization
Biological Process
Retrograde transport, endosome to Golgi
Biological Process
Transcytosis

▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mal-4635Mandrillus leucophaeus100.01e-83 286
LLPS-Mam-2852Macaca mulatta99.870.01535
LLPS-Cas-3569Carlito syrichta99.870.01535
LLPS-Man-0077Macaca nemestrina99.870.01535
LLPS-Pap-4376Pan paniscus99.870.01535
LLPS-Pat-3777Pan troglodytes99.870.01535
LLPS-Hos-4545Homo sapiens99.870.01535
LLPS-Bot-2359Bos taurus99.870.01536
LLPS-Aon-2433Aotus nancymaae99.870.01532
LLPS-Maf-4522Macaca fascicularis99.870.01535
LLPS-Chs-3969Chlorocebus sabaeus99.870.01535
LLPS-Caj-0601Callithrix jacchus99.870.01534
LLPS-Ora-3309Ornithorhynchus anatinus99.780.0 866
LLPS-Ict-3389Ictidomys tridecemlineatus99.750.01535
LLPS-Fec-2070Felis catus99.750.01532
LLPS-Paa-2994Papio anubis99.750.01533
LLPS-Ova-3349Ovis aries99.750.01531
LLPS-Mup-1064Mustela putorius furo99.750.01533
LLPS-Caf-3339Canis familiaris99.620.01534
LLPS-Urm-3922Ursus maritimus99.620.01535
LLPS-Orc-3692Oryctolagus cuniculus99.620.01529
LLPS-Otg-4219Otolemur garnettii99.620.01533
LLPS-Cea-0445Cercocebus atys99.620.01531
LLPS-Sus-1218Sus scrofa99.620.01535
LLPS-Fud-3533Fukomys damarensis99.620.01531
LLPS-Poa-3636Pongo abelii99.50.01528
LLPS-Loa-3009Loxodonta africana99.50.01528
LLPS-Aim-1935Ailuropoda melanoleuca99.50.01531
LLPS-Cap-3266Cavia porcellus99.370.01524
LLPS-Nol-3685Nomascus leucogenys99.370.01516
LLPS-Mod-4112Monodelphis domestica99.370.01530
LLPS-Sah-2743Sarcophilus harrisii99.370.01530
LLPS-Mea-3185Mesocricetus auratus99.370.01528
LLPS-Gog-2720Gorilla gorilla99.370.01530
LLPS-Ran-4279Rattus norvegicus99.250.01528
LLPS-Mum-0136Mus musculus99.250.01527
LLPS-Tag-2926Taeniopygia guttata98.490.01519
LLPS-Anp-2631Anas platyrhynchos98.490.01517
LLPS-Pes-3597Pelodiscus sinensis98.240.01511
LLPS-Gaga-3492Gallus gallus98.110.01506
LLPS-Meg-0193Meleagris gallopavo98.110.01514
LLPS-Fia-0027Ficedula albicollis97.750.01509
LLPS-Anc-2136Anolis carolinensis97.480.01511
LLPS-Leo-1683Lepisosteus oculatus95.730.01485
LLPS-Rhb-2140Rhinopithecus bieti95.60.01458
LLPS-Scf-1305Scleropages formosus94.350.01474
LLPS-Asm-0446Astyanax mexicanus93.970.01466
LLPS-Dar-2806Danio rerio93.840.01463
LLPS-Icp-1327Ictalurus punctatus93.770.01349
LLPS-Eqc-4088Equus caballus93.590.01409
LLPS-Ten-3234Tetraodon nigroviridis92.720.01452
LLPS-Xet-0714Xenopus tropicalis92.70.01430
LLPS-Orn-1061Oreochromis niloticus92.470.01454
LLPS-Scm-1440Scophthalmus maximus92.230.01446
LLPS-Gaa-1371Gasterosteus aculeatus92.230.01450
LLPS-Tar-0506Takifugu rubripes92.110.01444
LLPS-Xim-0687Xiphophorus maculatus91.840.01438
LLPS-Pof-2079Poecilia formosa91.750.01375
LLPS-Myl-1094Myotis lucifugus91.730.01409
LLPS-Dio-3690Dipodomys ordii91.450.01358
LLPS-Lac-3939Latimeria chalumnae73.220.01076
LLPS-Usm-0249Ustilago maydis63.922e-111 373
LLPS-Cis-1327Ciona savignyi63.830.0 954
LLPS-Pug-1103Puccinia graminis63.798e-105 350
LLPS-Spr-1495Sporisorium reilianum63.614e-111 372
LLPS-Mel-1101Melampsora laricipopulina63.462e-104 349
LLPS-Abg-1119Absidia glauca62.661e-109 363
LLPS-Miv-1173Microbotryum violaceum62.171e-103 347
LLPS-Crn-0465Cryptococcus neoformans62.177e-108 358
LLPS-Cii-0867Ciona intestinalis61.480.0 972
LLPS-Drm-1929Drosophila melanogaster60.940.0 969
LLPS-Pytr-0654Pyrenophora triticirepentis57.337e-93 316
LLPS-Lem-0599Leptosphaeria maculans57.333e-92 315
LLPS-Pyt-1129Pyrenophora teres57.331e-92 316
LLPS-Dos-1616Dothistroma septosporum57.06e-93 317
LLPS-Cog-1025Colletotrichum gloeosporioides57.08e-92 313
LLPS-Fus-1370Fusarium solani56.962e-94 321
LLPS-Asfu-1489Aspergillus fumigatus56.827e-91 311
LLPS-Nef-0765Neosartorya fischeri56.826e-91 311
LLPS-Mao-1428Magnaporthe oryzae56.821e-91 314
LLPS-Zyt-0044Zymoseptoria tritici56.734e-95 323
LLPS-Cogr-1463Colletotrichum graminicola56.681e-91 313
LLPS-Coo-0838Colletotrichum orbiculare56.682e-91 313
LLPS-Fuo-1478Fusarium oxysporum56.653e-94 320
LLPS-Fuv-0833Fusarium verticillioides56.654e-94 320
LLPS-Gag-0061Gaeumannomyces graminis56.498e-93 317
LLPS-Map-1133Magnaporthe poae56.492e-92 316
LLPS-Blg-1593Blumeria graminis56.453e-92 315
LLPS-Trv-1371Trichoderma virens56.173e-91 312
LLPS-Aso-0328Aspergillus oryzae56.172e-89 307
LLPS-Nec-1414Neurospora crassa56.172e-91 313
LLPS-Asf-0810Aspergillus flavus56.172e-89 307
LLPS-Phn-0222Phaeosphaeria nodorum56.153e-92 315
LLPS-Asc-1082Aspergillus clavatus56.092e-89 307
LLPS-Beb-1455Beauveria bassiana55.952e-93 318
LLPS-Asn-0547Aspergillus nidulans55.956e-90 308
LLPS-Trr-1209Trichoderma reesei55.817e-91 311
LLPS-Ved-1388Verticillium dahliae55.663e-92 315
LLPS-Ast-0475Aspergillus terreus55.524e-88 303
LLPS-Asni-1071Aspergillus niger54.156e-89 305
LLPS-Cae-1767Caenorhabditis elegans48.610.0 747
LLPS-Orbr-1601Oryza brachyantha46.010.0 592
LLPS-Sac-1232Saccharomyces cerevisiae45.81e-79 281
LLPS-Php-0067Physcomitrella patens45.640.0 620
LLPS-Sob-1309Sorghum bicolor45.60.0 611
LLPS-Lep-1717Leersia perrieri45.480.0 605
LLPS-Sei-2329Setaria italica45.480.0 606
LLPS-Org-1913Oryza glaberrima45.350.0 605
LLPS-Orgl-1792Oryza glumaepatula45.350.0 605
LLPS-Orb-2173Oryza barthii45.350.0 605
LLPS-Ori-2247Oryza indica45.350.0 605
LLPS-Orni-0154Oryza nivara45.350.0 605
LLPS-Orr-2080Oryza rufipogon45.230.0 602
LLPS-Ors-0821Oryza sativa45.230.0 602
LLPS-Hov-1798Hordeum vulgare45.230.0 605
LLPS-Tra-2972Triticum aestivum45.230.0 605
LLPS-Amt-0620Amborella trichopoda45.090.0 613
LLPS-Arl-0190Arabidopsis lyrata45.040.0 589
LLPS-Thc-0790Theobroma cacao45.030.0 595
LLPS-Tum-0134Tuber melanosporum44.910.0 624
LLPS-Brd-1882Brachypodium distachyon44.850.0 600
LLPS-Sem-1462Selaginella moellendorffii44.720.0 613
LLPS-Mua-0386Musa acuminata44.650.0 606
LLPS-Phv-0649Phaseolus vulgaris44.60.0 597
LLPS-Tru-1313Triticum urartu44.442e-180 543
LLPS-Put-1054Puccinia triticina44.390.0 616
LLPS-Viv-0634Vitis vinifera44.350.0 607
LLPS-Via-2100Vigna angularis44.350.0 595
LLPS-Gor-1988Gossypium raimondii43.950.0 603
LLPS-Met-2165Medicago truncatula43.910.0 593
LLPS-Bro-1453Brassica oleracea43.840.0 596
LLPS-Brr-2869Brassica rapa43.840.0 597
LLPS-Brn-2283Brassica napus43.840.0 597
LLPS-Cus-2333Cucumis sativus43.830.0 583
LLPS-Pot-0558Populus trichocarpa43.750.0 594
LLPS-Nia-2492Nicotiana attenuata43.70.0 598
LLPS-Prp-1600Prunus persica43.560.0 589
LLPS-Coc-1148Corchorus capsularis43.550.0 592
LLPS-Glm-1648Glycine max43.540.0 583
LLPS-Orp-0332Oryza punctata43.470.0 565
LLPS-Zem-0653Zea mays43.450.0 592
LLPS-Mae-2005Manihot esculenta43.250.0 589
LLPS-Art-3012Arabidopsis thaliana43.180.0 578
LLPS-Sot-1673Solanum tuberosum43.160.0 599
LLPS-Sol-0951Solanum lycopersicum43.160.0 593
LLPS-Hea-0963Helianthus annuus42.930.0 577
LLPS-Dac-1454Daucus carota42.660.0 581
LLPS-Orm-0002Oryza meridionalis41.834e-171 527
LLPS-Asg-1499Ashbya gossypii40.618e-73 261
LLPS-Chr-0358Chlamydomonas reinhardtii40.111e-114 377
LLPS-Yal-0909Yarrowia lipolytica39.670.0 563
LLPS-Chc-0124Chondrus crispus37.42e-87 302
LLPS-Scj-0513Schizosaccharomyces japonicus37.247e-154 478
LLPS-Osl-0063Ostreococcus lucimarinus36.983e-150 468
LLPS-Vir-1213Vigna radiata35.541e-93 309
LLPS-Scp-0357Schizosaccharomyces pombe34.98e-138 435
LLPS-Scc-1265Schizosaccharomyces cryophilus34.842e-135 429
LLPS-Kop-1141Komagataella pastoris33.893e-123 397
LLPS-Gas-1398Galdieria sulphuraria31.322e-89 305
LLPS-Cym-1096Cyanidioschyzon merolae29.591e-1379.3