LLPS-Tar-a170
PLCB4
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase |
| Gene Name: | PLCB4 |
| Ensembl Gene: | ENSTRUG00000009253.2 |
| Ensembl Protein: | ENSTRUP00000023270.2 |
| Organism: | Takifugu rubripes |
| Taxa ID: | 31033 |
| LLPS Type: | Others |
▼ PROPERTY
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSTRUT00000023367.2 | ENSTRUP00000023270.2 |
| Ensembl | ENSTRUT00000023366.2 | ENSTRUP00000023269.2 |
| UniProt | H2TF26, H2TF26_TAKRU | |
| RefSeq | XM_003971586.2 | XP_003971635.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MTKSYEFNWQ KHLPEFMQDG ASFDRFDEDP YMFEPSCHMK VDEYGFFITW KSEGKEGQVL 60 61 ECSLINSIRV GAVPKDPKIL SSFEAIGKTE ADLEGCIICI CSGTDLVNIN FMFMVAENPE 120 121 TARKWIEGLR SVIHNFKANN VCPMTCLKKH WMRMCFSTNV NGKIPVRGIT RTFASGKTEK 180 181 GIFQALKDLG LPSGKNDEIE QSDFTFDIFY ALTQKICPRT DIEELFKKIN GNKTDYLTVD 240 241 QLVSFLNENQ RDPRLNEILF PFYDNKRAMQ IIEKYERDAE LKKKGQMSSD GFCRYLMSDE 300 301 NAPVFLDRLE LYQEMDQPLA HYFISSSHNT YLTGRQFGGK SSVEMYRQVL LSGSRCVELD 360 361 CWDGKGEDQE PIITHGKAMC TDILFKDVIQ AIKETAFVTS DYPVILSFEN HCSKPQQYKM 420 421 AKYCEEIFGE LLLKQPLENF PIESGRPLPS PNDLKRKILI KNKRLKPEVE QKQLEAFKKH 480 481 MEAGETNTSA IIMGEENEDE TENGEKEAED KDVNSEAPSS LSEATSDKES NSVKSKKDEE 540 541 RNNSIKKVPE DEVTEMSEAT DATDISEASD QDNNKKGGEE EEESEEALIA QYTYVGATTN 600 601 IHPWLSAMVN YAQPVKFQSF DVAEERNIHH NMSSFNESVG LGYLKTNAIE FVNYNKRQMS 660 661 RIYPKGGRVD SSNYMPQIFW NAGCQMVSLN FQTPDLAMQL NQGKFEYNGS CGYLLKPDFM 720 721 RRSDRMFDPF SETPVDGVIA AHCSVQVFSG QFLSDKKIGT YVEVDMYGLP TDTIRKEFRT 780 781 RMVMNNGLNP AYNEEPFVFR KVILPDLAVL RIAVYDDNNK LIGQRILPLD GLQAGYRHIS 840 841 LRNEGNKPLS LPTIFCQIIL KTYVPDGFGA IVDALSDPKK FLTIAEKRAD QMKALGIDTT 900 901 DIADVPSGSS KGDKKGKGKG ETVKASVTPQ ASSDMAQTSN ATQNNIAETK KDPALVPNVS 960 961 IDDLKQMKTY LKLLKKQQKE LGALKKKQSK EQNTMQKAHC TQVDKMVSQH DKEKMVLEKL 1020 1021 LEKAIKKRGE NNCQELKKET EDKIQTLVTD HKAKVKDITA QHTKEWSDLI SSQSNEEQEM 1080 1081 KDSHVTQQCD HLKKLLATVQ EQQTMQLKLI QERQSKEMRA NQAKISMENS KAISQDKSIK 1140 1141 NKAERERRVR ELNSSNTKKF LDERKRLAMK HQKEMEQLEK NQREQLEKLE KFNEQLLKSH 1200 1201 HANKLVQGQG HAADGEVGGG DGPQTCHSGV KD 1232 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGACCAAAT CTTACGAGTT CAACTGGCAG AAGCACCTGC CTGAGTTCAT GCAGGATGGC 60 61 GCCTCCTTCG ACAGGTTTGA TGAGGACCCG TACATGTTTG AGCCCAGCTG CCATATGAAG 120 121 GTGGATGAGT ATGGCTTTTT CATCACGTGG AAGAGTGAGG GAAAGGAGGG CCAGGTTCTT 180 181 GAGTGTTCTC TCATCAACAG TATCCGTGTT GGCGCCGTCC CAAAGGACCC CAAGATTTTG 240 241 TCTTCATTCG AGGCCATTGG GAAGACAGAG GCAGATTTAG AGGGCTGCAT CATCTGCATC 300 301 TGCAGCGGCA CAGACCTGGT CAACATCAAC TTCATGTTCA TGGTGGCAGA AAATCCAGAG 360 361 ACTGCCAGGA AATGGATCGA GGGTTTGAGG TCAGTGATTC ACAACTTTAA GGCCAACAAC 420 421 GTCTGTCCAA TGACCTGCCT CAAGAAACAC TGGATGAGAA TGTGTTTCTC AACCAATGTG 480 481 AATGGGAAGA TTCCTGTGAG AGGCATCACG CGAACATTTG CATCAGGAAA AACAGAGAAG 540 541 GGGATCTTTC AGGCCCTAAA GGACCTTGGC CTTCCCAGTG GAAAGAATGA CGAGATCGAA 600 601 CAATCAGATT TTACCTTTGA CATTTTCTAC GCGCTCACAC AGAAGATCTG CCCTCGCACA 660 661 GATATAGAGG AATTATTCAA GAAGATCAAT GGGAACAAAA CTGATTATTT AACTGTAGAC 720 721 CAGTTAGTCA GCTTTCTGAA TGAAAACCAG CGTGACCCCA GGTTAAATGA GATACTCTTC 780 781 CCATTCTATG ACAACAAGAG AGCCATGCAG ATCATCGAGA AATACGAAAG AGACGCTGAA 840 841 CTGAAGAAGA AAGGTCAGAT GTCCAGCGAT GGCTTTTGCA GATACTTGAT GTCTGATGAG 900 901 AATGCACCTG TGTTCCTGGA TCGGCTGGAG CTCTACCAGG AGATGGACCA GCCACTGGCC 960 961 CACTACTTCA TCAGCTCCTC CCACAACACT TACCTGACCG GGCGTCAGTT TGGAGGGAAG 1020 1021 TCATCAGTGG AGATGTATCG TCAGGTGCTG CTGTCTGGAT CCAGGTGCGT AGAGCTGGAT 1080 1081 TGCTGGGATG GAAAAGGAGA GGACCAGGAG CCCATTATCA CTCATGGCAA GGCCATGTGC 1140 1141 ACGGACATCC TGTTCAAGGA TGTTATCCAG GCCATTAAAG AGACAGCATT TGTCACTTCA 1200 1201 GATTACCCTG TTATTTTGTC CTTTGAAAAC CACTGCAGTA AACCACAGCA GTACAAGATG 1260 1261 GCCAAATACT GTGAGGAGAT ATTTGGGGAA CTACTGCTAA AGCAGCCCCT GGAAAACTTC 1320 1321 CCGATTGAAT CTGGCCGCCC GTTACCCTCT CCAAATGATC TGAAACGCAA AATCCTCATC 1380 1381 AAGAACAAGA GATTGAAACC TGAAGTTGAG CAGAAACAGT TGGAGGCCTT TAAGAAACAC 1440 1441 ATGGAGGCAG GGGAGACTAA CACTTCTGCA ATTATTATGG GTGAAGAAAA TGAAGATGAG 1500 1501 ACAGAGAACG GTCAGGTTCC TGAAGATGAA GTGACAGAAA TGTCTGAAGC AACAGATGCC 1560 1561 ACAGATATCT CAGAAGCATC AGACCAAGAC AATAACAAAA AGGGTGGGGA GGAGGAGGAA 1620 1621 GAATCGGAAG AGGCTCTCAT AGCTCAGTAC ACCTACGTAG GTGCCACCAC TAATATCCAC 1680 1681 CCATGGCTCT CCGCCATGGT CAACTACGCA CAGCCAGTAA AGTTCCAGAG CTTTGATGTG 1740 1741 GCAGAGGAAA GGAACATCCA CCATAACATG TCATCCTTTA ATGAGTCTGT TGGCCTGGGC 1800 1801 TATCTGAAGA CCAATGCCAT CGAATTTGTC AACTACAACA AACGTCAGAT GAGCCGTATC 1860 1861 TACCCCAAAG GGGGCCGCGT GGACTCCAGT AATTACATGC CTCAGATCTT CTGGAACGCC 1920 1921 GGTTGCCAGA TGGTCTCTCT CAACTTCCAG ACCCCAGATC TGGCCATGCA GCTGAACCAG 1980 1981 GGGAAGTTTG AGTACAACGG CTCCTGCGGC TATCTGCTAA AGCCCGACTT TATGAGACGC 2040 2041 TCAGACAGGA TGTTTGACCC TTTCTCGGAG ACGCCGGTCG ATGGCGTCAT TGCTGCACAC 2100 2101 TGCAGTGTTC AGGTCTTCTC TGGACAGTTC TTGTCGGACA AAAAAATTGG CACATATGTA 2160 2161 GAGGTGGACA TGTACGGGCT GCCGACAGAC ACCATCCGCA AGGAGTTCCG CACACGTATG 2220 2221 GTGATGAACA ATGGGCTAAA CCCTGCGTAC AACGAAGAGC CCTTCGTGTT TAGAAAGGTA 2280 2281 ATTTTACCAG ATCTGGCGGT TCTGCGCATT GCTGTGTACG ATGATAACAA CAAGCTGATT 2340 2341 GGGCAACGCA TCCTGCCCCT GGACGGCCTG CAGGCTGGCT ACCGGCACAT TTCACTGAGG 2400 2401 AATGAAGGGA ACAAGCCCCT CTCATTGCCC ACCATTTTCT GCCAGATCAT CCTTAAGACC 2460 2461 TACGTGCCCG ACGGCTTTGG CGCTATTGTT GATGCCCTCT CAGATCCAAA GAAGTTCTTA 2520 2521 ACTATTGCAG AGAAGAGAGC TGACCAGATG AAGGCCCTGG GGATTGACAC GACTGATATC 2580 2581 GCAGACGTTC CCAGTGGAAG CTCAAAGGGT GACAAAAAGG GAAAGGGGAA AGGAGAAACG 2640 2641 GTGAAGGCCA GTGTGACACC ACAGGCCAGC TCAGACATGG CTCAGACCTC CAACGCCACC 2700 2701 CAAAACAACA TAGCAGAAAC AAAGAAGGAT CCTGCCCTCG TGCCTAATGT CAGCATCGAT 2760 2761 GACTTAAAAC AAATGAAGAC ATACCTTAAA CTGCTAAAAA AGCAACAGAA GGAACTTGGT 2820 2821 GCTTTAAAGA AGAAACAGTC AAAGGAACAA AATACAATGC AGAAAGCTCA CTGCACCCAG 2880 2881 GTGGACAAGA TGGTGTCGCA GCATGACAAG GAAAAGATGG TTTTGGAGAA ACTACTAGAG 2940 2941 AAGGCCATCA AGAAACGAGG GGAAAATAAC TGCCAAGAGT TAAAGAAAGA AACAGAGGAT 3000 3001 AAAATCCAAA CACTGGTCAC AGACCACAAA GCCAAGGTAA AGGACATCAC TGCGCAGCAC 3060 3061 ACTAAAGAGT GGTCAGATCT CATCAGCAGC CAAAGCAATG AGGAGCAGGA AATGAAGGAC 3120 3121 AGCCATGTGA CACAGCAGTG TGATCACCTA AAGAAGCTCC TGGCCACCGT GCAGGAGCAG 3180 3181 CAGACCATGC AGCTCAAGCT CATCCAGCAT TCCAGACAGA GCAAAGAAAT GCGAGCCAAC 3240 3241 CAGGCCAAGA TATCCATGGA AAACAGCAAA GCCATCAGCC AGGACAAGAG CATAAAAAAC 3300 3301 AAGGCAGAGA GAGAGAGGAG AGTAAGAGAG TTAAATAGCA GCAACACCAA GAAGTTCCTG 3360 3361 GATGAAAGAA AAAGGCTGGC CATGAAGCAT CAGAAGGAAA TGGAGCAACT GGAGAAAAAC 3420 3421 CAGAGAGAAC AGTTAGAGAA ACTGGAGAAG TTCAATGAGC AGGCCAAGGA CATGCAGCAG 3480 3481 ATGGTGAAGT TGGAGGAGGA GATGGACCGC AGACCTGCCA CAGTGGTGTG A 3531 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Molecular Function | Calcium ion binding | |
Molecular Function | Phosphatidylinositol phospholipase C activity | |
Biological Process | Intracellular signal transduction | |
Biological Process | Lipid catabolic process |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Hos-a202 | Homo sapiens | 0.0 | 1906 | undefined |
| LLPS-Mum-a198 | Mus musculus | 0.0 | 1863 | undefined |