DrLLPS - Data resource of LLPS

LLPS-Tar-0676
chac2

Integrated Annotations

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	Gamma-glutamylcyclotransferase
Gene Name:	chac2
Ensembl Gene:	ENSTRUG00000002998.2
Ensembl Protein:	ENSTRUP00000048796.1
Organism:	Takifugu rubripes
Taxa ID:	31033
LLPS Type:	Others

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Stress granule	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Saccharomyces cerevisiae	LLPS-Sac-0324	P32656	Client	Stress granule	38.07	3e-29	114

▼ FUNCTION

Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENSTRUT00000056947.1	ENSTRUP00000048796.1
Ensembl	ENSTRUT00000007055.2	ENSTRUP00000007010.2
UniProt		H2S3N8, H2S3N8_TAKRU

▼ SEQUENCE

Protein Sequence (FASTA)
1 MWVFGYGSLI WKVDFPYEDK RIGYIEGFSR RFWQGSTDHR GVPGQPGRVV TLVEDPEGDG 60 61 HGCVWGVAYK LPSGREQEVK RYLDHREKGG YRVISVSFHP RPSLSSSPQQ TLLYIGSPDD 120 121 PNFLGPAPLE EIANQIVSCT GPSGKNSEYL LELAEAVRTI LPEDRDAHLF SLETLVKHKL 180 181 LSSCKRAITA DANPNANTII 200
Nucleotide CDS Sequence (FASTA)
1 ATGTGGGTTT TTGGATACGG CTCTCTGATC TGGAAGGTGG ATTTTCCTTA TGAAGACAAG 60 61 AGGATTGGCT ACATTGAAGG CTTCAGCCGT CGGTTCTGGC AGGGGAGCAC CGACCACCGG 120 121 GGTGTCCCGG GCCAGCCCGG CCGGGTCGTG ACCCTGGTGG AGGATCCAGA GGGGGACGGT 180 181 CACGGCTGCG TTTGGGGCGT GGCCTACAAG CTGCCGTCGG GCCGGGAACA GGAAGTGAAG 240 241 CGGTACCTGG ACCACAGAGA GAAGGGCGGC TACCGGGTCA TCTCCGTCAG CTTCCACCCG 300 301 CGTCCGTCGC TCAGCTCTTC GCCCCAGCAG ACGCTGCTCT ACATCGGCTC TCCAGACGAT 360 361 CCCAACTTCC TGGGCCCCGC CCCTCTAGAG GAGATAGCCA ATCAGATCGT CAGCTGCACT 420 421 GGTCCCAGCG GGAAGAACTC GGAGTACCTG CTGGAGCTGG CAGAGGCCGT GAGGACGATC 480 481 CTGCCCGAGG ACAGAGACGC TCACCTGTTC TCCTTAGAAA CGCTGGTGAA GCACAAACTG 540 541 CTCAGCAGCT GCAAACGTGC TATCACAGCT GATGCTAATC CCAACGCTAA CACCATCATT 600 601 TAG 603

▼ KEYWORD

ID	Family
KW-0181	Complete proteome
KW-0456	Lyase
KW-1185	Reference proteome

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0003839	Molecular Function	Gamma-glutamylcyclotransferase activity
GO:0061928	Molecular Function	Glutathione specific gamma-glutamylcyclotransferase activity
GO:0006751	Biological Process	Glutathione catabolic process

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Ten-3112	Tetraodon nigroviridis	85.0	7e-100	294
LLPS-Orn-4070	Oreochromis niloticus	78.19	8e-100	294
LLPS-Scm-0522	Scophthalmus maximus	77.37	1e-95	285
LLPS-Xim-2515	Xiphophorus maculatus	77.22	1e-95	283
LLPS-Gaa-2843	Gasterosteus aculeatus	76.72	2e-95	283
LLPS-Pof-3207	Poecilia formosa	76.67	1e-95	283
LLPS-Dar-4182	Danio rerio	74.72	7e-92	273
LLPS-Leo-2763	Lepisosteus oculatus	72.68	2e-87	263
LLPS-Asm-0566	Astyanax mexicanus	71.89	1e-89	268
LLPS-Icp-0121	Ictalurus punctatus	71.2	2e-90	270
LLPS-Eqc-4316	Equus caballus	70.56	6e-86	258
LLPS-Pes-0492	Pelodiscus sinensis	70.0	2e-83	253
LLPS-Ova-4244	Ovis aries	70.0	8e-85	256
LLPS-Scf-3225	Scleropages formosus	69.95	2e-87	262
LLPS-Ict-0354	Ictidomys tridecemlineatus	69.44	3e-84	254
LLPS-Fec-0584	Felis catus	69.44	2e-84	254
LLPS-Loa-3664	Loxodonta africana	69.44	7e-84	253
LLPS-Dio-3476	Dipodomys ordii	69.44	3e-84	254
LLPS-Cas-2903	Carlito syrichta	68.89	4e-83	251
LLPS-Gaga-2072	Gallus gallus	68.89	2e-82	249
LLPS-Otg-0545	Otolemur garnettii	68.89	2e-84	254
LLPS-Orc-2357	Oryctolagus cuniculus	68.89	4e-83	254
LLPS-Mum-3508	Mus musculus	68.89	5e-83	251
LLPS-Sus-3902	Sus scrofa	68.89	4e-84	254
LLPS-Tag-1026	Taeniopygia guttata	68.33	1e-81	248
LLPS-Cap-3697	Cavia porcellus	68.33	1e-82	250
LLPS-Urm-3930	Ursus maritimus	68.33	4e-84	254
LLPS-Ran-2792	Rattus norvegicus	68.33	8e-83	250
LLPS-Mup-3589	Mustela putorius furo	68.33	1e-83	253
LLPS-Mea-1715	Mesocricetus auratus	68.33	3e-82	249
LLPS-Mod-1434	Monodelphis domestica	68.05	2e-76	234
LLPS-Aim-3048	Ailuropoda melanoleuca	68.0	5e-81	246
LLPS-Nol-0629	Nomascus leucogenys	67.78	1e-82	250
LLPS-Fud-2425	Fukomys damarensis	67.78	3e-83	251
LLPS-Xet-3827	Xenopus tropicalis	67.22	3e-79	241
LLPS-Poa-3538	Pongo abelii	67.22	2e-82	249
LLPS-Ere-0251	Erinaceus europaeus	67.22	2e-81	247
LLPS-Mam-2059	Macaca mulatta	66.67	2e-81	247
LLPS-Rhb-2009	Rhinopithecus bieti	66.67	9e-82	248
LLPS-Hos-4779	Homo sapiens	66.67	1e-81	248
LLPS-Pap-0470	Pan paniscus	66.67	1e-81	248
LLPS-Pat-2696	Pan troglodytes	66.67	1e-81	248
LLPS-Man-3659	Macaca nemestrina	66.67	2e-81	247
LLPS-Mal-2486	Mandrillus leucophaeus	66.67	1e-81	248
LLPS-Gog-4288	Gorilla gorilla	66.67	1e-81	248
LLPS-Caj-3340	Callithrix jacchus	66.67	6e-83	251
LLPS-Chs-4581	Chlorocebus sabaeus	66.67	1e-81	248
LLPS-Maf-3874	Macaca fascicularis	66.67	2e-81	247
LLPS-Cea-4217	Cercocebus atys	66.67	1e-81	248
LLPS-Caf-2942	Canis familiaris	66.49	2e-84	255
LLPS-Myl-1138	Myotis lucifugus	66.48	2e-81	247
LLPS-Aon-0511	Aotus nancymaae	66.48	5e-82	248
LLPS-Anp-2061	Anas platyrhynchos	66.45	2e-63	200
LLPS-Anc-0424	Anolis carolinensis	65.79	3e-79	245
LLPS-Sah-3721	Sarcophilus harrisii	65.26	1e-82	250
LLPS-Lac-1047	Latimeria chalumnae	65.24	5e-80	244
LLPS-Bot-0457	Bos taurus	62.78	4e-74	228
LLPS-Cis-0175	Ciona savignyi	60.89	2e-70	218
LLPS-Cii-1386	Ciona intestinalis	59.89	4e-70	218
LLPS-Nia-1411	Nicotiana attenuata	48.24	2e-39	139
LLPS-Sot-2092	Solanum tuberosum	48.19	4e-37	134
LLPS-Amt-2246	Amborella trichopoda	47.85	8e-40	140
LLPS-Paa-4191	Papio anubis	46.77	1e-49	168
LLPS-Hea-0658	Helianthus annuus	46.63	1e-37	135
LLPS-Tut-1044	Tursiops truncatus	46.59	5e-48	162
LLPS-Mae-2676	Manihot esculenta	45.95	4e-40	141
LLPS-Gag-0501	Gaeumannomyces graminis	45.27	1e-41	148
LLPS-Mao-0817	Magnaporthe oryzae	45.23	9e-43	149
LLPS-Bro-1708	Brassica oleracea	44.95	1e-37	135
LLPS-Orl-3074	Oryzias latipes	44.94	2e-44	152
LLPS-Prp-0706	Prunus persica	44.86	3e-40	144
LLPS-Sol-2429	Solanum lycopersicum	44.85	1e-38	137
LLPS-Drm-1355	Drosophila melanogaster	44.81	1e-40	146
LLPS-Gor-1247	Gossypium raimondii	44.68	8e-39	139
LLPS-Sem-1534	Selaginella moellendorffii	44.58	4e-34	125
LLPS-Brr-1014	Brassica rapa	44.44	4e-36	131
LLPS-Nec-0333	Neurospora crassa	44.33	9e-41	145
LLPS-Met-2037	Medicago truncatula	44.32	5e-35	128
LLPS-Trr-1387	Trichoderma reesei	44.2	4e-33	122
LLPS-Dac-1858	Daucus carota	44.15	1e-38	137
LLPS-Asn-0617	Aspergillus nidulans	44.12	2e-34	129
LLPS-Cus-0763	Cucumis sativus	44.04	1e-37	135
LLPS-Chr-0454	Chlamydomonas reinhardtii	43.96	6e-38	139
LLPS-Coc-0560	Corchorus capsularis	43.24	1e-36	132
LLPS-Viv-2493	Vitis vinifera	43.24	6e-39	138
LLPS-Thc-1736	Theobroma cacao	43.24	3e-37	134
LLPS-Brn-1421	Brassica napus	42.79	1e-36	132
LLPS-Phv-2237	Phaseolus vulgaris	42.7	5e-34	125
LLPS-Mel-0184	Melampsora laricipopulina	42.62	1e-36	132
LLPS-Fus-0802	Fusarium solani	42.51	1e-26	106
LLPS-Miv-1435	Microbotryum violaceum	42.47	7e-37	134
LLPS-Fuo-1580	Fusarium oxysporum	42.31	9e-25	101
LLPS-Fuv-0371	Fusarium verticillioides	42.31	7e-25	101
LLPS-Art-2994	Arabidopsis thaliana	42.16	9e-37	133
LLPS-Yal-1241	Yarrowia lipolytica	42.08	5e-39	140
LLPS-Phn-1520	Phaeosphaeria nodorum	42.03	4e-37	135
LLPS-Abg-1612	Absidia glauca	42.02	7e-40	141
LLPS-Pot-0703	Populus trichocarpa	41.9	5e-37	135
LLPS-Coo-1626	Colletotrichum orbiculare	41.89	4e-23	97.4
LLPS-Zyt-1372	Zymoseptoria tritici	41.62	9e-38	136
LLPS-Via-1287	Vigna angularis	41.62	1e-32	122
LLPS-Php-2123	Physcomitrella patens	41.62	1e-33	125
LLPS-Glm-1604	Glycine max	41.62	2e-34	126
LLPS-Arl-2058	Arabidopsis lyrata	41.41	2e-34	127
LLPS-Cogr-0904	Colletotrichum graminicola	41.22	5e-23	97.1
LLPS-Org-0939	Oryza glaberrima	41.21	2e-33	124
LLPS-Ors-1462	Oryza sativa	41.21	2e-33	124
LLPS-Tra-0465	Triticum aestivum	41.21	9e-34	124
LLPS-Orgl-1373	Oryza glumaepatula	41.21	2e-33	124
LLPS-Orni-2316	Oryza nivara	41.21	2e-33	124
LLPS-Ori-1265	Oryza indica	41.21	2e-33	124
LLPS-Orb-1117	Oryza barthii	41.21	2e-33	124
LLPS-Cym-1147	Cyanidioschyzon merolae	40.98	1e-31	120
LLPS-Brd-1898	Brachypodium distachyon	40.61	1e-32	122
LLPS-Pug-0256	Puccinia graminis	40.51	9e-36	130
LLPS-Cog-0723	Colletotrichum gloeosporioides	40.4	7e-24	99.0
LLPS-Trv-1622	Trichoderma virens	40.3	3e-29	114
LLPS-Dos-1464	Dothistroma septosporum	40.0	4e-39	140
LLPS-Mua-2468	Musa acuminata	39.89	6e-27	106
LLPS-Asg-0650	Ashbya gossypii	39.71	5e-29	113
LLPS-Vir-0820	Vigna radiata	39.41	7e-27	107
LLPS-Sob-0025	Sorghum bicolor	39.02	8e-32	119
LLPS-Orp-2095	Oryza punctata	39.0	2e-35	130
LLPS-Scj-1532	Schizosaccharomyces japonicus	38.92	1e-30	117
LLPS-Cae-1252	Caenorhabditis elegans	38.89	4e-30	116
LLPS-Map-0672	Magnaporthe poae	38.86	4e-30	117
LLPS-Sei-1929	Setaria italica	38.82	3e-32	122
LLPS-Scc-1598	Schizosaccharomyces cryophilus	38.22	4e-33	123
LLPS-Sac-0324	Saccharomyces cerevisiae	38.07	7e-28	110
LLPS-Lep-0991	Leersia perrieri	38.0	6e-34	126
LLPS-Gas-1263	Galdieria sulphuraria	37.82	8e-35	128
LLPS-Aso-0968	Aspergillus oryzae	37.8	2e-18	84.7
LLPS-Asc-1645	Aspergillus clavatus	37.79	4e-18	83.6
LLPS-Tum-1545	Tuber melanosporum	37.74	3e-23	97.4
LLPS-Asni-1587	Aspergillus niger	37.63	2e-26	107
LLPS-Osl-0717	Ostreococcus lucimarinus	37.57	6e-28	109
LLPS-Orm-0479	Oryza meridionalis	37.5	1e-34	127
LLPS-Orbr-2120	Oryza brachyantha	37.5	1e-33	125
LLPS-Crn-1412	Cryptococcus neoformans	37.44	1e-34	128
LLPS-Orr-1295	Oryza rufipogon	37.31	2e-34	127
LLPS-Asf-1552	Aspergillus flavus	36.89	7e-11	62.4
LLPS-Blg-0051	Blumeria graminis	36.84	3e-15	73.9
LLPS-Scp-0551	Schizosaccharomyces pombe	36.65	9e-31	117
LLPS-Hov-0469	Hordeum vulgare	35.5	1e-31	120
LLPS-Asfu-1613	Aspergillus fumigatus	35.39	1e-27	111
LLPS-Ved-0195	Verticillium dahliae	35.11	1e-19	88.2
LLPS-Tru-1001	Triticum urartu	35.0	2e-31	119
LLPS-Scs-0847	Sclerotinia sclerotiorum	34.46	3e-20	89.7
LLPS-Kop-0599	Komagataella pastoris	34.31	5e-22	94.7
LLPS-Lem-1045	Leptosphaeria maculans	34.2	2e-18	85.1
LLPS-Nef-1463	Neosartorya fischeri	34.07	1e-20	91.3
LLPS-Ast-1415	Aspergillus terreus	33.67	2e-13	70.5
LLPS-Zem-2283	Zea mays	29.22	1e-21	94.0
LLPS-Pytr-1506	Pyrenophora triticirepentis	29.21	2e-15	75.5

LLPS-Tar-0676chac2

Protein Sequence

Nucleotide Sequence

LLPS-Tar-0676
chac2