• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Tar-0654
smc1a

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: Structural maintenance of chromosomes protein
Gene Name: smc1a
Ensembl Gene: ENSTRUG00000014137.2
Ensembl Protein: ENSTRUP00000036167.2
Organism: Takifugu rubripes
Taxa ID: 31033
LLPS Type: Others


▼ PROPERTY



▼ Classification


Condensates:
CondensateEvidenceOrthologs
Nucleolus, Centrosome/Spindle pole body, P-bodyPredicted from orthologs(View)

▼ CROSS REFERENCE


▼ SEQUENCE


Protein Sequence (FASTA)
1     MGYLKLIEIE  NFKSYKGRQI  IGPFHKFTAI  IGPNGSGKSN  LMDAISFVLA  ERTSNLRVKT  60
61    LKDLIHGAPV  GKPAANRAFV  SMVYQQDSGD  ELAFTRVIIG  SSSEYRINNK  VVGLPEYSEE  120
121   LEKLGILIKA  RNFLVFQGAV  ESIAMKNPKE  RTALFEEISR  SGELAQEYDR  RKKEMVKAEE  180
181   DTQFNYHRKK  NIAAERKEAK  QEKEEAERYQ  RLKDEVARAS  IQLQLFKLYH  NETEIEKLNK  240
241   ELGQRNKEID  KDRKRMDLVE  EELKDKKKEL  GRLMREQQTI  EKEIKEKDSE  LNQKRPQYIK  300
301   AKENTSHKIK  KLEAARKSLQ  NAQKMYKKRK  GDMDELDKEM  KAVELAKQDF  EERMEEEAQS  360
361   QGQDLTLEEN  QVKKYHRLKE  EASKRAATLA  QELEKFNRDQ  KADQDRLDLE  ERKKVETEAK  420
421   IKQKIREIEE  NQKRIEKLED  YITTSRQSLD  EQKRMEEELT  EEVEMAKRRI  DEINMELNQV  480
481   MEQLGDARID  RQENSRQQRK  AEIMESIKRL  YPGSVYGRLI  DLCQPTQKKY  QIAVTKVLGK  540
541   NMDAIIVDSE  KTGRDCIQYI  KEQRGEPETF  LPLDYLEVKP  TDEKLRELRG  AKLVIDVIRY  600
601   EPPQIKKALQ  YACGNALVCD  NVEDARRIAF  GGPYRHKTVA  LDGTLFQKSG  VISGGASDLK  660
661   AKARRWDEKA  VDKLKEKKEK  LTDELKEQMK  AKRKEAELRQ  VQSQAHGLQM  RLKYSQSDLE  720
721   QTKTRHLSLN  MQEKSKLESE  LANFGPRIND  IKRIIQSRER  EINDLRDRMN  QVEDEVFVEF  780
781   CKEIGVRNIR  EFEEEKVKRQ  NEIAKKRLEF  ETQKTRLGIQ  VDYEKNQLKE  DQEKVMMWEQ  840
841   TVKKDDAEIE  RLKKEEHRHM  KIIDETMAQL  QDLKNQHLTK  KSEVNDKNHE  MEEIRKKLGG  900
901   ANKELTQLQK  EVTAIETKLE  QKRSDRHNLL  QACKMQDIRL  PLISGTLDDM  NQGEGSSQAD  960
961   DSSSQRTSST  VLAKEALIEI  DYSNLSEDLK  DTLSEEEIKA  ETNTLQQRLN  EQQSILQRIS  1020
1021  APNMKAMEKL  ESVRDKFQET  SDEFEAARKR  AKKAKQAFEQ  IKKERFDRFN  TCFESVATNI  1080
1081  DEIYKALSRN  SSAQAFLGPE  NPEEPYLDGI  NYNCVAPGKR  FRPMDNLSGG  EKTVAALALL  1140
1141  FAIHSYKPAP  FFVLDEIDAA  LDNTNIGKVA  NYIKDQSVQN  FQAIVISLKE  EFYTKADSLI  1200
1201  GVYPEQGDCV  ISKVLTFDLS  QYPDANPNPN  E  1231
Nucleotide CDS Sequence (FASTA)
1     ATGGGTTATT  TGAAATTAAT  AGAGATCGAA  AACTTTAAGT  CCTACAAAGG  AAGACAGATC  60
61    ATTGGACCAT  TTCATAAGTT  CACAGCAATC  ATCGGACCCA  ATGGATCTGG  GAAATCCAAT  120
121   CTTATGGATG  CCATCAGTTT  CGTGTTGGCA  GAAAGAACCA  GTAACCTGCG  TGTAAAGACT  180
181   CTGAAGGATT  TGATCCATGG  AGCACCGGTG  GGAAAGCCAG  CAGCCAACAG  AGCTTTTGTC  240
241   AGTATGGTGT  ACCAGCAGGA  CAGTGGCGAC  GAGCTCGCCT  TCACCAGAGT  CATCATTGGT  300
301   TCATCCTCTG  AGTACCGTAT  CAATAATAAG  GTGGTGGGAC  TGCCCGAATA  CAGCGAAGAG  360
361   CTTGAAAAGC  TCGGTATTCT  GATCAAGGCT  CGGAACTTCC  TGGTTTTCCA  GGGAGCTGTG  420
421   GAGTCTATTG  CCATGAAGAA  CCCCAAGGAG  CGGACTGCTT  TGTTTGAAGA  AATCTCCCGT  480
481   TCTGGAGAAC  TGGCTCAAGA  GTACGACCGC  AGGAAAAAGG  AGATGGTGAA  GGCGGAGGAG  540
541   GACACTCAGT  TTAATTACCA  CCGTAAGAAA  AATATCGCCG  CTGAACGAAA  AGAAGCCAAA  600
601   CAAGAAAAAG  AAGAGGCTGA  GCGTTATCAG  CGCCTGAAAG  ATGAAGTGGC  CAGGGCCAGT  660
661   ATTCAGTTGC  AGCTCTTCAA  ATTATACCAT  AATGAGACTG  AGATTGAGAA  GCTAAACAAA  720
721   GAGCTGGGCC  AGCGGAACAA  AGAGATTGAT  AAGGACCGTA  AAAGGATGGA  CCTGGTGGAA  780
781   GAGGAGCTGA  AGGACAAAAA  GAAGGAGCTT  GGCAGGCTGA  TGAGGGAGCA  GCAGACCATT  840
841   GAGAAGGAAA  TTAAAGAAAA  GGATTCTGAA  TTGAACCAAA  AGAGGCCCCA  GTACATCAAG  900
901   GCCAAGGAGA  ACACCTCACA  CAAGATCAAG  AAGCTCGAGG  CTGCACGCAA  ATCACTGCAA  960
961   AATGCTCAGA  AGATGTATAA  AAAACGCAAA  GGAGACATGG  ACGAGCTGGA  TAAAGAGATG  1020
1021  AAGGCCGTAG  AGTTGGCCAA  GCAAGATTTT  GAGGAGCGTA  TGGAAGAGGA  GGCCCAGAGC  1080
1081  CAGGGCCAGG  ACCTCACCCT  GGAGGAAAAC  CAGGTAAAAA  AGTACCACCG  TCTGAAGGAG  1140
1141  GAGGCTAGCA  AACGTGCTGC  CACACTGGCA  CAGGAGCTCG  AGAAGTTCAA  CCGTGACCAG  1200
1201  AAAGCCGACC  AGGACCGCCT  GGACCTGGAG  GAGAGGAAGA  AAGTGGAGAC  AGAGGCCAAG  1260
1261  ATCAAACAGA  AGATTCGGGA  AATTGAGGAA  AACCAGAAGC  GTATTGAAAA  ATTAGAAGAT  1320
1321  TATATAACAA  CCAGCAGGCA  GTCGCTTGAT  GAGCAAAAGC  GCATGGAAGA  GGAGCTGACT  1380
1381  GAGGAAGTCG  AAATGGCCAA  GAGGAGAATA  GATGAGATCA  ACATGGAGCT  CAACCAGGTA  1440
1441  ATGGAGCAGC  TGGGTGATGC  CAGAATCGAC  CGGCAGGAGA  ACAGTCGTCA  GCAGCGTAAG  1500
1501  GCCGAGATTA  TGGAGAGCAT  CAAAAGACTG  TACCCAGGCT  CTGTGTATGG  CCGTCTTATT  1560
1561  GACCTGTGCC  AGCCCACTCA  GAAGAAGTAT  CAGATTGCTG  TGACAAAGGT  GCTTGGCAAA  1620
1621  AACATGGATG  CCATCATTGT  TGACTCTGAG  AAGACTGGCA  GAGATTGTAT  TCAGTACATT  1680
1681  AAGGAACAGA  GAGGAGAGCC  CGAGACCTTC  CTTCCTCTCG  ACTACCTTGA  GGTAAAACCA  1740
1741  ACAGATGAGA  AGCTGAGAGA  GCTACGAGGA  GCCAAACTGG  TGATAGACGT  GATTCGCTAC  1800
1801  GAGCCTCCTC  AAATCAAGAA  AGCCCTCCAG  TACGCTTGTG  GTAATGCCCT  GGTTTGTGAC  1860
1861  AATGTAGAGG  ACGCCCGACG  GATTGCTTTT  GGTGGACCGT  ACAGGCACAA  GACGGTTGCC  1920
1921  CTGGATGGCA  CTCTGTTCCA  GAAGTCTGGA  GTCATCTCTG  GAGGAGCCAG  TGATTTGAAG  1980
1981  GCCAAGGCTA  GACGTTGGGA  TGAGAAAGCA  GTGGACAAGC  TGAAGGAGAA  AAAAGAAAAA  2040
2041  CTTACAGATG  AACTCAAGGA  GCAAATGAAG  GCCAAGAGGA  AGGAGGCAGA  GTTGCGTCAG  2100
2101  GTCCAGTCTC  AGGCCCACGG  TCTTCAGATG  AGACTCAAGT  ATTCCCAGAG  TGATCTGGAG  2160
2161  CAGACGAAAA  CCCGCCACCT  CTCGCTTAAC  ATGCAGGAGA  AATCTAAGCT  GGAGAGCGAG  2220
2221  TTGGCCAATT  TTGGCCCTCG  CATCAATGAC  ATTAAGAGGA  TCATCCAGTC  CCGCGAGAGG  2280
2281  GAGATCAATG  ACCTGCGAGA  CCGGATGAAC  CAGGTGGAGG  ACGAGGTGTT  TGTTGAATTC  2340
2341  TGTAAGGAGA  TTGGGGTGAG  AAACATCAGA  GAGTTCGAGG  AAGAGAAAGT  AAAGAGGCAG  2400
2401  AATGAGATCG  CAAAGAAGCG  TCTTGAATTT  GAGACTCAGA  AGACCCGTCT  GGGTATCCAA  2460
2461  GTCGACTATG  AGAAGAATCA  GCTAAAGGAG  GACCAGGAGA  AGGTCATGAT  GTGGGAGCAG  2520
2521  ACTGTCAAGA  AGGACGACGC  TGAAATCGAG  CGGCTAAAAA  AGGAGGAGCA  CAGGCACATG  2580
2581  AAGATAATCG  ATGAGACGAT  GGCCCAACTG  CAGGACCTGA  AGAACCAGCA  CCTCACTAAG  2640
2641  AAATCCGAAG  TCAATGATAA  GAATCACGAG  ATGGAGGAAA  TCCGCAAGAA  ACTGGGTGGT  2700
2701  GCCAACAAAG  AGTTGACTCA  GCTACAGAAG  GAAGTGACCG  CTATCGAAAC  CAAACTGGAG  2760
2761  CAGAAGAGGA  GCGACCGTCA  CAATCTGCTA  CAAGCCTGTA  AAATGCAGGA  TATCAGACTG  2820
2821  CCTCTTATCT  CTGGAACACT  GGATGACATG  AACCAAGGAG  AGGGGAGTTC  CCAGGCTGAT  2880
2881  GACTCCAGCA  GCCAGAGGAC  GTCCAGCACT  GTTCTCGCTA  AGGAGGCTCT  CATAGAGATC  2940
2941  GACTATAGTA  ACCTGTCTGA  AGACCTAAAG  GATACGTTGT  CGGAAGAAGA  AATCAAAGCA  3000
3001  GAGACAAACA  CGCTGCAGCA  GCGTCTGAAC  GAGCAGCAGA  GCATCCTCCA  GAGGATCAGC  3060
3061  GCGCCCAATA  TGAAAGCCAT  GGAGAAGCTC  GAGAGCGTCC  GGGACAAATT  TCAAGAGACC  3120
3121  AGTGACGAGT  TTGAGGCAGC  CCGTAAAAGA  GCCAAGAAGG  CCAAACAGGC  CTTTGAGCAG  3180
3181  ATCAAGAAGG  AACGGTTCGA  TCGCTTCAAT  ACTTGTTTCG  AGTCGGTGGC  CACAAACATC  3240
3241  GATGAGATCT  ATAAGGCCCT  CTCACGCAAC  AGCAGTGCCC  AGGCTTTCCT  TGGCCCAGAG  3300
3301  AATCCCGAAG  AGCCCTATCT  GGATGGAATC  AACTACAACT  GTGTGGCTCC  AGGGAAGAGG  3360
3361  TTCAGACCCA  TGGACAACCT  GTCTGGAGGA  GAGAAGACTG  TTGCTGCCCT  GGCTCTGCTC  3420
3421  TTTGCAATTC  ACAGCTACAA  ACCCGCCCCC  TTCTTTGTCC  TGGATGAGAT  TGATGCCGCC  3480
3481  TTGGACAACA  CAAACATCGG  CAAGGTGGCC  AATTACATCA  AGGACCAGTC  TGTACAGAAC  3540
3541  TTCCAGGCTA  TTGTTATTTC  CCTCAAGGAG  GAATTCTACA  CCAAGGCAGA  CTCGCTTATC  3600
3601  GGCGTTTATC  CAGAGCAAGG  AGACTGCGTC  ATTAGCAAAG  TGCTGACCTT  TGACCTCTCT  3660
3661  CAGTATCCTG  ATGCCAACCC  TAATCCAAAC  GAGTAG  3696

▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ten-0817Tetraodon nigroviridis98.860.02245
LLPS-Pof-2827Poecilia formosa97.40.02197
LLPS-Xim-1251Xiphophorus maculatus97.320.02194
LLPS-Orl-1252Oryzias latipes97.240.02226
LLPS-Scm-0695Scophthalmus maximus97.240.02205
LLPS-Orn-0516Oreochromis niloticus97.240.02204
LLPS-Gaa-3294Gasterosteus aculeatus97.160.02220
LLPS-Scf-0371Scleropages formosus94.240.02144
LLPS-Icp-1963Ictalurus punctatus94.240.02131
LLPS-Asm-0132Astyanax mexicanus93.830.02131
LLPS-Gog-2009Gorilla gorilla93.82e-136 450
LLPS-Dar-0197Danio rerio93.510.02136
LLPS-Chs-2762Chlorocebus sabaeus91.060.01825
LLPS-Leo-3006Lepisosteus oculatus90.880.0 570
LLPS-Aim-1238Ailuropoda melanoleuca90.430.02076
LLPS-Mup-0490Mustela putorius furo90.430.02076
LLPS-Caf-0161Canis familiaris90.430.02076
LLPS-Anp-1212Anas platyrhynchos90.430.0 592
LLPS-Fec-0838Felis catus90.430.02076
LLPS-Bot-4533Bos taurus90.350.02075
LLPS-Tut-0173Tursiops truncatus90.350.02076
LLPS-Mal-0427Mandrillus leucophaeus90.350.02073
LLPS-Cea-2930Cercocebus atys90.350.02073
LLPS-Mea-2027Mesocricetus auratus90.350.02075
LLPS-Maf-1949Macaca fascicularis90.350.02073
LLPS-Mum-2394Mus musculus90.350.02075
LLPS-Caj-2881Callithrix jacchus90.350.02073
LLPS-Mam-1775Macaca mulatta90.350.02073
LLPS-Ict-1175Ictidomys tridecemlineatus90.350.02075
LLPS-Man-0832Macaca nemestrina90.350.02073
LLPS-Pat-0463Pan troglodytes90.350.02073
LLPS-Pap-0106Pan paniscus90.350.02073
LLPS-Hos-1789Homo sapiens90.350.02073
LLPS-Rhb-1364Rhinopithecus bieti90.350.02073
LLPS-Poa-1438Pongo abelii90.30.01997
LLPS-Ova-0472Ovis aries90.270.02071
LLPS-Fud-0092Fukomys damarensis90.190.02072
LLPS-Sus-3152Sus scrofa90.170.02017
LLPS-Myl-0326Myotis lucifugus90.120.02073
LLPS-Anc-0614Anolis carolinensis90.110.02083
LLPS-Otg-0514Otolemur garnettii89.970.02065
LLPS-Nol-2416Nomascus leucogenys89.940.02059
LLPS-Sah-1566Sarcophilus harrisii89.880.02043
LLPS-Orc-4069Oryctolagus cuniculus89.780.0 632
LLPS-Eqc-2959Equus caballus89.742e-1482.8
LLPS-Dio-0186Dipodomys ordii89.310.01625
LLPS-Aon-2713Aotus nancymaae89.120.02047
LLPS-Ran-0243Rattus norvegicus88.970.02025
LLPS-Cas-0901Carlito syrichta88.80.02032
LLPS-Lac-0664Latimeria chalumnae88.660.02051
LLPS-Ora-2143Ornithorhynchus anatinus88.530.0 983
LLPS-Paa-1470Papio anubis87.430.01979
LLPS-Cap-2787Cavia porcellus87.280.01969
LLPS-Xet-0807Xenopus tropicalis87.210.01998
LLPS-Loa-0324Loxodonta africana86.50.02031
LLPS-Urm-0314Ursus maritimus82.040.01774
LLPS-Gaga-1857Gallus gallus74.293e-52 189
LLPS-Cii-1711Ciona intestinalis65.792e-78 261
LLPS-Cis-0837Ciona savignyi54.10.01213
LLPS-Mod-2934Monodelphis domestica53.910.01215
LLPS-Pes-2697Pelodiscus sinensis53.860.0 638
LLPS-Fia-1495Ficedula albicollis52.860.01161
LLPS-Meg-1907Meleagris gallopavo52.480.01156
LLPS-Tag-0999Taeniopygia guttata52.160.01165
LLPS-Put-0009Puccinia triticina50.02e-1172.8
LLPS-Drm-0534Drosophila melanogaster48.290.01023
LLPS-Yal-0231Yarrowia lipolytica47.784e-38 160
LLPS-Cae-0042Caenorhabditis elegans41.670.0 837
LLPS-Prp-0337Prunus persica40.626e-108 361
LLPS-Cus-1832Cucumis sativus40.391e-108 361
LLPS-Ors-1539Oryza sativa40.261e-106 356
LLPS-Sei-1548Setaria italica40.03e-86 297
LLPS-Tru-1438Triticum urartu39.751e-111 377
LLPS-Phv-1658Phaseolus vulgaris38.275e-62 223
LLPS-Amt-1298Amborella trichopoda38.22e-86 298
LLPS-Glm-1521Glycine max38.121e-23 112
LLPS-Php-0753Physcomitrella patens37.30.0 674
LLPS-Vir-0395Vigna radiata37.183e-90 323
LLPS-Hea-2249Helianthus annuus37.060.0 629
LLPS-Orbr-0561Oryza brachyantha37.060.0 674
LLPS-Orgl-0056Oryza glumaepatula36.930.0 650
LLPS-Mua-1907Musa acuminata36.80.0 687
LLPS-Thc-0609Theobroma cacao36.790.0 640
LLPS-Hov-0809Hordeum vulgare36.770.0 652
LLPS-Tra-2177Triticum aestivum36.750.0 655
LLPS-Met-0680Medicago truncatula36.750.0 637
LLPS-Zem-0331Zea mays36.720.0 624
LLPS-Viv-0587Vitis vinifera36.74e-59 219
LLPS-Orni-0022Oryza nivara36.680.0 651
LLPS-Orr-0830Oryza rufipogon36.680.0 651
LLPS-Sem-1593Selaginella moellendorffii36.670.0 652
LLPS-Sob-1140Sorghum bicolor36.650.0 628
LLPS-Art-2078Arabidopsis thaliana36.630.0 647
LLPS-Brd-0921Brachypodium distachyon36.610.0 659
LLPS-Pot-0166Populus trichocarpa36.570.0 637
LLPS-Sol-0083Solanum lycopersicum36.530.0 639
LLPS-Via-1817Vigna angularis36.410.0 579
LLPS-Bro-2223Brassica oleracea36.120.0 634
LLPS-Brr-1625Brassica rapa36.110.0 630
LLPS-Arl-1079Arabidopsis lyrata36.050.0 612
LLPS-Mae-0571Manihot esculenta35.970.0 639
LLPS-Lep-0643Leersia perrieri35.860.0 607
LLPS-Gor-1099Gossypium raimondii35.790.0 627
LLPS-Nia-0684Nicotiana attenuata35.740.0 639
LLPS-Ori-1784Oryza indica35.490.0 637
LLPS-Asc-0411Aspergillus clavatus35.490.0 622
LLPS-Dac-1072Daucus carota35.360.0 601
LLPS-Orb-0466Oryza barthii35.225e-22 107
LLPS-Org-1503Oryza glaberrima35.225e-22 107
LLPS-Coc-0839Corchorus capsularis35.160.0 605
LLPS-Orp-0196Oryza punctata35.043e-178 577
LLPS-Brn-1468Brassica napus35.00.0 580
LLPS-Scc-0276Schizosaccharomyces cryophilus34.950.0 619
LLPS-Usm-0306Ustilago maydis34.90.0 633
LLPS-Spr-0552Sporisorium reilianum34.630.0 631
LLPS-Asn-0083Aspergillus nidulans34.610.0 601
LLPS-Tum-0870Tuber melanosporum34.590.0 626
LLPS-Cog-0213Colletotrichum gloeosporioides34.370.0 609
LLPS-Nef-1308Neosartorya fischeri34.30.0 613
LLPS-Aso-0208Aspergillus oryzae34.280.0 599
LLPS-Asfu-0451Aspergillus fumigatus34.270.0 607
LLPS-Fuo-1046Fusarium oxysporum34.190.0 588
LLPS-Cogr-0922Colletotrichum graminicola34.140.0 600
LLPS-Abg-0115Absidia glauca34.040.0 581
LLPS-Chc-0307Chondrus crispus33.960.0 586
LLPS-Fuv-0279Fusarium verticillioides33.810.0 580
LLPS-Beb-1002Beauveria bassiana33.590.0 588
LLPS-Ast-0112Aspergillus terreus33.523e-174 555
LLPS-Asf-0599Aspergillus flavus33.52e-173 555
LLPS-Blg-0220Blumeria graminis33.460.0 593
LLPS-Scs-0725Sclerotinia sclerotiorum33.390.0 596
LLPS-Nec-0852Neurospora crassa33.360.0 585
LLPS-Miv-0070Microbotryum violaceum33.364e-178 567
LLPS-Scp-1335Schizosaccharomyces pombe33.280.0 587
LLPS-Osl-0241Ostreococcus lucimarinus33.250.0 575
LLPS-Crn-0152Cryptococcus neoformans33.124e-177 563
LLPS-Pug-0520Puccinia graminis33.02e-177 564
LLPS-Coo-0231Colletotrichum orbiculare32.990.0 595
LLPS-Ved-0062Verticillium dahliae32.890.0 585
LLPS-Gag-0005Gaeumannomyces graminis32.694e-176 561
LLPS-Trv-0096Trichoderma virens32.631e-180 573
LLPS-Mao-0665Magnaporthe oryzae32.386e-173 553
LLPS-Pytr-0668Pyrenophora triticirepentis32.334e-167 538
LLPS-Pyt-0656Pyrenophora teres32.31e-166 537
LLPS-Map-0737Magnaporthe poae32.33e-173 554
LLPS-Scj-0813Schizosaccharomyces japonicus31.930.0 594
LLPS-Phn-0955Phaeosphaeria nodorum30.985e-134 447
LLPS-Lem-0356Leptosphaeria maculans30.564e-153 500
LLPS-Cym-0613Cyanidioschyzon merolae30.558e-133 445
LLPS-Kop-0491Komagataella pastoris30.445e-147 483
LLPS-Sac-0208Saccharomyces cerevisiae29.993e-98 346
LLPS-Asg-0075Ashbya gossypii29.99e-148 484
LLPS-Gas-0459Galdieria sulphuraria28.962e-133 446